Chronic fine particulate matter exposure, habitual exercise, and dyslipidemia: A longitudinal cohort study

Abstract

What this study adds• This is the first large-scale cohort study investigating the combined effects of habitual exercise and chronic exposure to fine particulate matter (PM 2.5 ) on dyslipidemia. • Increased levels of exercise and reduced exposure to PM 2.5 are associated with a lower incidence of dyslipidemia. • Although the association between habitual exercise and dyslipidemia is slightly attenuated by PM 2.5 exposure, the negative associations between dyslipidemia and habitual exercise remains, regardless of the level of PM 2.5 exposure. • Habitual exercise is beneficial for dyslipidemia prevention, even for people residing in Taiwan, which has an annual PM 2.5 concentration of 26.7 μg/m 3 .

Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter

“…The enhanced systemic and hepatic lipid metabolism prior to xenobiotics stimulation upon NMN treatment might confer mice with resistance to lipid accumulation caused by acute oxidative stress. Although it has been reported that prolonged oxidative stress and pro-inflammatory cytokines secreted from the lung triggers dyslipidemia, hepatic lipid accumulation, and subsequent extra-pulmonary injury, 56 , 57 it is unclear whether NMN intervention leads to attenuation in PM-induced inflammation through the modulation of lipid metabolism. Our results revealed that NMN supplementation effectively lowered the proportions of recruited and activated MDSCs and prevented profibrotic phenotype differentiation.…”