Chronic fatigue syndrome: Inflammation, immune function, and neuroendocrine interactions

Klimas, Nancy G.; Koneru, Anne O.Brien

doi:10.1007/s11926-007-0078-y

Cited by 91 publications

(78 citation statements)

References 30 publications

(17 reference statements)

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“…Moreover, the model associated the syndrome with the minor allele of 5HTT_7911132, a SNP that belongs to a gene that decreases the level of active serotonin when the allelic variants with increased transcriptional activity are present (21). Taken together, these findings agree with an additive effect that leads to a lower level of cortisol (22,23) and to alterations in the neurotransmission and in the immune function (24, 25) already described in the chronic fatigue syndrome (Figure 4). …”

Section: Discussionsupporting

confidence: 89%

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

Cifuentes

Barreto

2011

biomedica

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Introduction:The different ways for selecting single nucleotide polymorphisms have been related to paradoxical conclusions about their usefulness in predicting chronic fatigue syndrome even when using the same dataset. Objective: To evaluate the efficacy in predicting this syndrome by using polymorphisms selected by a supervised approach that is claimed to be a method that helps identifying their optimal profile. Materials and methods: We eliminated those polymorphisms that did not meet the Hardy-Weinberg equilibrium. Next, the profile of polymorphisms was obtained through the supervised approach and three aspects were evaluated: comparison of prediction accuracy with the accuracy of a profile that was based on linkage disequilibrium, assessment of the efficacy in determining a higher risk stratum, and estimating the algorithm influence on accuracy. Results: A valid profile (p<0.01) was obtained with a higher accuracy than the one based on linkage disequilibrium, 72.8 vs. 62.2% (p<0.01). This profile included two known polymorphisms associated with chronic fatigue syndrome, the NR3C1_11159943 major allele and the 5HTT_7911132 minor allele. Muscular pain or sinus nasal symptoms in the stratum with the profile predicted V with a higher accuracy than those symptoms in the entire dataset, 87.1 vs. 70.4% (p<0.01) and 92.5 vs. 71.8% (p<0.01) respectively. The profile led to similar accuracies with different algorithms. Conclusions: The supervised approach made it possible to discover a reliable profile of polymorphisms associated with this syndrome. Using this profile, accuracy for this dataset was the highest reported and it increased when the profile was combined with clinical data.

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Section: Discussionsupporting

confidence: 89%

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

Cifuentes

Barreto

2011

biomedica

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“…Recent years have witnessed a surge in interdisciplinary efforts to delineate the pathophysiology of chronic fatigue syndrome (CFS), a debilitating disorder of unknown etiology with no known lesions, biomarkers or laboratory tests for diagnosis [1] . Neuroendocrine and immune system deregulation as well as perturbations in cognitive, sleep and metabolic functions have been documented in CFS [1][2][3] .…”

Section: Introductionmentioning

confidence: 99%

“…Neuroendocrine and immune system deregulation as well as perturbations in cognitive, sleep and metabolic functions have been documented in CFS [1][2][3] . Further, twin, family and candidate gene studies support a moderate genetic contribution to the development of CFS [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome

et al. 2011

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Background: There is no consistent evidence of specific gene(s) or molecular pathways that contribute to the pathogenesis, therapeutic intervention or diagnosis of chronic fatigue syndrome (CFS). While multiple studies support a role for genetic variation in CFS, genome-wide efforts to identify associated loci remain unexplored. We employed a novel convergent functional genomics approach that incorporates the findings from single-nucleotide polymorphism (SNP) and mRNA expression studies to identify associations between CFS and novel candidate genes for further investigation. Methods: We evaluated 116,204 SNPs in 40 CFS and 40 nonfatigued control subjects along with mRNA expression of 20,160 genes in a subset of these subjects (35 CFS subjects and 27 controls) derived from a population-based study. Results: Sixty-five SNPs were nominally associated with CFS (p < 0.001), and 165 genes were differentially expressed (≧4-fold; p ≤ 0.05) in peripheral blood mononuclear cells of CFS subjects. Two genes, glutamate receptor, ionotropic, kinase 2 (GRIK2) and neuronal PAS domain protein 2 (NPAS2), were identified by both SNP and gene expression analyses. Subjects with the G allele of rs2247215 (GRIK2) were more likely to have CFS (p = 0.0005), and CFS subjects showed decreased GRIK2 expression (10-fold; p = 0.015). Subjects with the T allele of rs356653 (NPAS2) were more likely to have CFS (p = 0.0007), and NPAS2 expression was increased (10-fold; p = 0.027) in those with CFS. Conclusion: Using an integrated genomic strategy, this study suggests a possible role for genes involved in glutamatergic neurotransmission and circadian rhythm in CFS and supports further study of novel candidate genes in independent populations of CFS subjects.

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“…There is also a growing suspicion that chronic obscure viruses may be involved, directly or indirectly, in chronic pain and fatigue syndromes. [1][2][3] The role of natural killer (NK) cells in combating viral disease is known to involve many aspects of NK cell biology and interaction with other cell types such as macrophages and dendritic cells. The production of interferons (IFNs), combined with NK cell trafficking, is an important aspect of immune surveillance against viral infections.…”

Section: Introduction Tmentioning

confidence: 99%

Antioxidant Bioavailability and Rapid Immune-Modulating Effects After Consumption of a Single Acute Dose of a High-Metabolite Yeast Immunogen: Results of a Placebo-Controlled Double-Blinded Crossover Pilot Study

Jensen

Redman²,

Benson³

et al. 2011

Journal of Medicinal Food

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The objective of this pilot study was to investigate the acute effects on circulating lymphocyte subsets, antioxidant status, and cytokine profile after consumption of EpiCor Ò (EP) (Embria Health Sciences, Ankeny, IA, USA), a dried fermentate produced from Saccharomyces cerevisiae, using a placebo-controlled randomized crossover study design with 12 healthy adult human subjects. EP contains high levels of bioavailable antioxidants and strongly activates natural killer (NK) cells in vitro. EP consumption has been shown to increase erythrocyte hematocrit levels, boost mucosal immune protection, reduce cold/flu symptoms, reduce seasonal allergy symptoms and the need for rescue medication, and increase salivary secretory immunoglobulin A levels. This warranted further study on immune effects in humans. A within-subject analysis of data collected before and at 1 and 2 hours after consumption of a single dose of 500 mg of EP versus placebo was performed. A transient reduction in circulating T and NK cell numbers was observed 2 hours post-consumption, suggesting that homing and recirculation of these cells, as part of healthy immune surveillance, were supported by EP. The increased expression of activation markers on the CD3 -CD56 + NK cell population was significant for CD69 at 1 hour post-consumption (CD25, P < .07; CD69, P < .05), whereas for CD25 it was significant at 2 hours after consumption (CD25, P < .03; CD69, P < .15). A rapid increase in serum interferon-c was observed at 1 hour post-consumption (P < .07; after removal of two outlying data sets, P < .05) and may have contributed to the effects seen on NK and T cell subsets. Significant increase in serum antioxidant protection was seen 2 hours after consumption (P < .04). Thus consumption of a single 500 mg dose of EP provides a rapid and transient effect on the trafficking and activation status of specific lymphocyte subsets, as well as increased antioxidant protection. KEY WORDS: antioxidants CD25 CD69 cytokines EpiCorÒ natural killer cells Th1/Th2 T lymphocytes

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Chronic fatigue syndrome: Inflammation, immune function, and neuroendocrine interactions

Cited by 91 publications

References 30 publications

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

Selección supervisada de polimorfismos de nucleótido único en el síndrome de fatiga crónica

Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome

Antioxidant Bioavailability and Rapid Immune-Modulating Effects After Consumption of a Single Acute Dose of a High-Metabolite Yeast Immunogen: Results of a Placebo-Controlled Double-Blinded Crossover Pilot Study

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