Chronic exposure to MDMA (ecstasy)induces DNA damage, impairs functional antioxidant cellular defenses, enhances the lipid peroxidation process and alters testes histopathology in male rat.

Zaki, Nadia G.; Kawy, Laila Abdel

doi:10.21608/ejhm.2013.15992

Cited by 1 publication

(2 citation statements)

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“…The rats were divided into four groups of nine rats each (one control and four experimental groups). Experimental groups 1–3 received 0.2 mL of a solution by a gavage that contained 0.5, 1, and 2 mg of methamphetamine/kg body weight for 45 consecutive days . Methamphetamine was obtained in tablets from the Antinarcotic General Administration, Deputy of Food and Drug, Shiraz University of Medical Sciences, Iran.…”

Section: Methodsmentioning

confidence: 99%

“…Street methamphetamine has various impurities and additives and is known as Speed, Chuck, and Matt. − Methamphetamine abuse among adolescents and young adultsthe reproductive age groupsis on the rise, and it has turned into a social dilemma. , Many studies have been conducted on the effects of methamphetamine on the male reproductive system. − It has been shown that daily administration of methamphetamine in rats decreased the body, testicular, and epididymis weights . Also, methamphetamine can cause apoptosis in seminiferous tubules and changes of serum testosterone levels in male mice and rats. ,− , It can decrease the proliferation of spermatogonia and the ratio of proliferation/apoptosis in seminiferous tubules of rats . Methamphetamine has been reported to reduce the normal sperm count and morphology and increase apoptotic cells in seminiferous tubules. , Nudmamud-Thanoi et al.…”

Section: Introductionmentioning

confidence: 99%

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Methamphetamine Downregulates the Sperm-Specific Calcium Channels Involved in Sperm Motility in Rats

et al. 2022

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Calcium channels play essential roles in sperm motility. A family of sperm-specific cation channels including CatSper1–4 has been identified as voltage-dependent ion channels that act as sperm motility regulators. Methamphetamine is known to cause apoptosis in seminiferous tubules and affect sperm quality. This research was conducted to investigate the effects of methamphetamine on expression of the CatSper family and Mvh genes. Thirty-six adult Wistar rats were divided into four groups of nine rats each: the control and experimental groups 1, 2, and 3. The control group received no solvents or drugs, but experimental groups 1, 2, and 3 were daily given 0.2 mL of a solution by gavage that contained 0.5, 1, and 2 mg of methamphetamine, respectively, for 45 days. The rats were then anesthetized, and one testis removed from each rat was used in a reverse transcription-polymerase chain reaction (RT-PCR). Analysis of variance (ANOVA) and Tukey’s posthoc test were used to analyze the data at the P < 0.05 significance level. Treatment with methamphetamine resulted in decreased testis and epididymis weights compared to the control rats. The results showed that the mRNA fold expression level of the CatSper family and Mvh genes decreased significantly in experimental groups compared to that in the control (P < 0.05). Methamphetamine decreased the expression levels of the CatSper and Mvh genes, and thus, it seemed that it can increase the probability of infertility through sperm motility reduction by lowering the expression levels of these genes.

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Section: Methodsmentioning

confidence: 99%