Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage.

Abstract

This information is current as signaling in the alveolar macrophage. factor receptor expression and downstream granulocyte-macrophage colony-stimulating Chronic ethanol ingestion in rats decreases

Chronic-Alcohol-Abuse-Induced Oxidative Stress in the Development of Acute Respiratory Distress Syndrome

“…Thus, the impaired terminal differentiation of AM associated with chronic ethanol ingestion may be a consequence of alcohol-induced decreases in the expression of GM-CSF receptors and PU.1. This is further supported by the observation that treatment of the ethanol-fed rat with recombinant GM-CSF restored GM-CSF receptor expression and signaling as well as AM differentiation and accompanying immune functions [ 72 ]. Whether GM-CSF treatments of the ethanol-fed rat restore GSH pools and attenuate oxidative stress remains to be determined.…”

“…Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a trophic factor for the alveolar epithelium which secretes GM-CSF into the ELF where it is required for the priming of ATII cells. In ATII cells derived from ethanol-fed rats, there is decreased expression of GM-CSF receptors and this is associated with loss of barrier integrity [ 63 , 72 ]. In the endotoxemia model, in vivo treatments with GM-CSF dramatically improved alveolar epithelial barrier integrity, particularly in the ethanol-fed rat.…”

“…For immune cells, GM-CSF stimulates the production of granulocytes and monocytes, their migration into tissue, and their maturation into AM and dendritic cells. However, chronic alcohol ingestion also decreases the expression of GM-CSF receptors in AM [ 72 ]. In parallel, ethanol ingestion decreased cellular expression and nuclear binding of PU.1, the master transcription factor that activates GM-CSF-dependent AM functions.…”

Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defects

“…Moreover, these studies report significant defects in both the innate and adaptive branches of the immune system (10), especially within alveolar macrophages (AM), the first line of defense in the lung (25). Specifically, prolonged alcohol exposure alters the ability of AM to release cytokines and chemokines needed to recruit immune cells into the lung (26,27) as well as their ability to clear both microbes and dying cells to reduce damage to tissue (28) potentially due to oxidative stress (29). The molecular basis for altered macrophage metabolism and function in the lung with alcohol is yet to be determined.…”

Alcohol Use Disorders Affect Antimicrobial Proteins and Anti-pneumococcal Activity in Epithelial Lining Fluid Obtained via Bronchoalveolar Lavage

“…Lysozyme and lactoferrin are manufactured by serous epithelial cells and myeloid lineage cells, including neutrophils and alveolar macrophages. Alcohol consumption has been reported to affect innate immune functions of alveolar macrophages, including their production of cytokines important in host defense (Standiford and Danforth, 1997), and decreasing the expression of the granulocyte-monocyte colony stimulating factor receptor (Joshi et al, 2005(Joshi et al, , 2006. AUDs are also known to result in excessive oxidation in ELF that may have potential ramifications on transcription and translation of antimicrobial proteins by serous epithelial cells or resident alveolar macrophages (Yeh et al, 2007).…”