Chronic environmental inorganic arsenic exposure causes social behavioral changes in juvenile zebrafish (Danio rerio)

Wang, Yihong; Wang, Yaqian; Yu, Xiaogang; Lin, Yin; Liu, Junxia; Wang, Wei‐Ye; Yan, Chen‐Hua

doi:10.1016/j.scitotenv.2022.161296

Cited by 9 publications

(1 citation statement)

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“…Chronic arsenic exposure altered social behavior, a characteristic of autism, in juvenile zebrafish, which was ameliorated by the antioxidant N-acetylcysteine [ 37 ]. In zebrafish larvae, arsenic caused motor behavioral deficit as well as mild impairment in behavior towards color preference [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Neurogenic Effects of Inorganic Arsenic and Cdk5 Knockdown in Zebrafish Embryos: A Perspective on Modeling Autism

Gu,

Kanungo

2024

IJMS

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The exact mechanisms of the development of autism, a multifactorial neurological disorder, are not clear. The pathophysiology of autism is complex, and investigations at the cellular and molecular levels are ongoing to provide clarity. Mutations in specific genes have been identified as risk factors for autism. The role of heavy metals in the pathogenesis of autism is subject to many studies and remains debatable. Although no exact neuronal phenotypes have been identified linked to autistic symptoms, overproduction and reduction of specific neurons have been implicated. A growing literature on generating genetic and non-genetic models of autism aims to help with understanding mechanistic studies that can explain the complexity of the disorder. Both genetic and non-genetic methods of zebrafish have been used to model autism. For several human autism risk genes, validated zebrafish mutant models have been generated. There is growing evidence indicating a potential link between autism and inorganic arsenic exposure. We have previously shown that inorganic arsenic induces supernumerary spinal motor neurons via Sonic hedgehog (Shh) signaling pathway, and Cdk5 knockdown causes an overproduction of cranial and spinal motor neurons in zebrafish. Here, in this review, we provide a perspective on what these findings of neurogenic phenotypes mean in terms of dysregulated pathways of motor neuron development and their applicability to understanding cellular and molecular underpinnings of autism.

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Section: Introductionmentioning

confidence: 99%