Chronic enhancement of brain oxytocin levels causes enduring anti-aggressive and pro-social explorative behavioral effects in male rats

Calcagnoli, Federica; Meyer, Neele; Boer, Sietse F. de; Althaus, Monika; Koolhaas, Jaap M.

doi:10.1016/j.yhbeh.2014.03.008

Cited by 48 publications

(31 citation statements)

References 48 publications

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“…Moreover, Maejima and colleagues showed that reductions in body weight gain persisted for 9 days following termination of OT treatment in DIO mice [28]. Furthermore, the effects of OT on exploratory and anti-aggressive behavior continued for at least 1 week following the end of treatment in male rats [176]. Similarly, the effects of chronic intracerebroventricular (ICV) or subcutaneous administration of OT to reduce blood pressure persisted for nearly 10 days after OT treatment ended in male and female rats [177].…”

Section: What Contributes To Ot's Prolonged Effects To Reduce Body Wementioning

confidence: 99%

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Blevins

Baskin

2015

Physiology & Behavior

124

100

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The fact that more than 78 million adults in the US are considered overweight or obese highlights the need to develop new, effective strategies to treat obesity and its associated complications, including type 2 diabetes, kidney disease and cardiovascular disease. While the neurohypophyseal peptide oxytocin (OT) is well recognized for its peripheral effects to stimulate uterine contraction during parturition and milk ejection during lactation, release of OT within the brain is implicated in prosocial behaviors and in the regulation of energy balance. Previous findings indicate that chronic administration of OT decreases food intake and weight gain or elicits weight loss in diet-induced obese (DIO) mice and rats. Furthermore, chronic systemic treatment with OT largely reproduces the effects of central administration to reduce weight gain in DIO and genetically obese rodents at doses that do not appear to result in tolerance. These findings have now been recently extended to more translational models of obesity showing that chronic subcutaneous or intranasal OT treatment is sufficient to elicit body weight loss in DIO nonhuman primates and pre-diabetic obese humans. This review assesses the potential use of OT as a therapeutic strategy for treatment of obesity in rodents, nonhuman primates, and humans, and identifies potential mechanisms that mediate this effect.

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Section: What Contributes To Ot's Prolonged Effects To Reduce Body Wementioning

confidence: 99%

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Blevins

Baskin

2015

Physiology & Behavior

124

100

View full text Add to dashboard Cite

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“…It has been suggested [86] and recently observed [87][88][89] that the numerous oxytocin (OT) fibers traversing the IHA and contacting the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) may pose an additional inhibitory influence on aggression.…”

Section: Afferent Connectionsmentioning

confidence: 99%

The neurobiology of offensive aggression: Revealing a modular view

Boer

Olivier

Veening

et al. 2015

Physiology & Behavior

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“…Oxytocin (OXT) and argininevasopressin (AVP), closely-related nonapeptides, are mainly synthesized in the supraoptic and paraventricular nuclei of the hypothalamus. OXT plays key regulatory roles in affiliative and social behaviors as has been revealed by substantial studies in rodents [1][2][3] and other species [4,5], including humans [6]. Similarly, AVP is also involved in the regulation of social behaviors including social preference [7], social memory [8], social bonding [9], and aggression [10].…”

Section: Introductionmentioning

confidence: 96%

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Zhang

Dai

et al. 2016

Neurosci. Bull.

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Autism spectrum disorder (ASD) is defined by impairments of social interaction and the presence of obsessive behaviors. The ''twin'' nonapeptides oxytocin (OXT) and arginine-vasopressin (AVP) are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of children. As expected, children with ASD had lower plasma OXT levels than gender-matched controls (P = 0.028). No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication (Rho = -0.22, P = 0.076), while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects (Rho = -0.231, P = 0.079). Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children (P = 0.072). In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

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Chronic enhancement of brain oxytocin levels causes enduring anti-aggressive and pro-social explorative behavioral effects in male rats

Cited by 48 publications

References 48 publications

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans

The neurobiology of offensive aggression: Revealing a modular view

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

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