Chronic endometritis: screening, treatment, and pregnancy outcomes in an academic fertility center

HogenEsch, Elena; Hojjati, Ronus; Komorowski, Allison S.; Maniar, Kruti P.; Pavone, Mary Ellen; Bakkensen, Jennifer B.; Bernardi, Lia A.

doi:10.1007/s10815-023-02902-z

Cited by 5 publications

(2 citation statements)

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“…CE is attracting interest because of its association with female infertility, including unexplained etiology (10–57%) [ 9 , 10 , 11 ], endometriosis (5–53%) [ 12 , 13 , 14 , 15 , 16 ], repeated implantation failure in an in vitro fertilization–embryo transfer program (7–31%) [ 7 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], unexplained recurrent pregnancy loss (9–13%) [ 27 , 28 , 29 , 30 , 31 , 32 ], fallopian tubal infertility (45.9% of hydrosalpinx, 14.3% of peritubal adhesion, and 13.0% of tubal occlusion) [ 33 , 34 , 35 , 36 ], polycystic ovarian syndrome (32–42%) [ 37 ], endometrial polyps (86%) [ 38 , 39 , 40 , 41 , 42 , 43 ], submucosal uterine fibroids (69%) [ 44 ], septate uterus (46%) [ 44 ], intrauterine adhesion/Asherman syndrome (28–79%) [ 44 , 45 , 46 , 47 ], and cesarean scar disorder (28–66%) [ 48 , 49 ]. The European Society of Human Reproduction and Embryology Working Group recently published Good Practice Recommendations on Recurrent Implantation Failure 2023, a document in which assessment for CE can be considered for infertile women suffering from repeated implantation failure following in vitro fertilization–embryo transfer programs and tre...…”

Section: Introductionmentioning

confidence: 99%

“…CE is attracting interest because of its association with female infertility, including unexplained etiology (10-57%) [9][10][11], endometriosis (5-53%) [12][13][14][15][16], repeated implantation failure in an in vitro fertilization-embryo transfer program (7-31%) [7,[17][18][19][20][21][22][23][24][25][26], unexplained recurrent pregnancy loss (9-13%) [27][28][29][30][31][32], fallopian tubal infertility (45.9% of hydrosalpinx, 14.3% of peritubal adhesion, and 13.0% of tubal occlusion) [33][34][35][36], polycystic ovarian syndrome (32-42%) [37], endometrial polyps (86%) [38][39][40][41][42][43], submucosal uterine fibroids (69%) [44], septate uterus (46%) [44], intrauterine adhesion/Asherman syndrome (28-79%) [44][45][46][47], and cesarean scar disorder (28-66%) [48,49]. The European Society of Human Reproduction and Embryology Working Group recently published Good Practice Recommendations on R...…”

Section: Introductionmentioning

confidence: 99%

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Bridging the Diagnostic Gap between Histopathologic and Hysteroscopic Chronic Endometritis with Deep Learning Models

Kitaya,

Yasuo,

Yamaguchi

2024

Medicina

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Chronic endometritis (CE) is an inflammatory pathologic condition of the uterine mucosa characterized by unusual infiltration of CD138(+) endometrial stromal plasmacytes (ESPCs). CE is often identified in infertile women with unexplained etiology, tubal factors, endometriosis, repeated implantation failure, and recurrent pregnancy loss. Diagnosis of CE has traditionally relied on endometrial biopsy and histopathologic/immunohistochemistrical detection of ESPCs. Endometrial biopsy, however, is a somewhat painful procedure for the subjects and does not allow us to grasp the whole picture of this mucosal tissue. Meanwhile, fluid hysteroscopy has been recently adopted as a less-invasive diagnostic modality for CE. We launched the ARCHIPELAGO (ARChival Hysteroscopic Image-based Prediction for histopathologic chronic Endometritis in infertile women using deep LeArninG mOdel) study to construct the hysteroscopic CE finding-based prediction tools for histopathologic CE. The development of these deep learning-based novel models and computer-aided detection/diagnosis systems potentially benefits infertile women suffering from this elusive disease.

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