Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization

Johnston-MacAnanny, Erika B.; Hartnett, Janice; Engmann, Lawrence; Nulsen, John; Sanders, Melinda; Benadiva, Claudio

doi:10.1016/j.fertnstert.2008.12.131

Cited by 329 publications

(375 citation statements)

References 20 publications

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“…33 The pathogenicity of Gram-negative rods in chronic endometritis has been supported by the fact that single or combination antibiotic therapies with oral administration of doxycycline, ciprofloxacin, metronidazole, and cefixime for weeks was effective for clearance of stromal plasmacytes and improvement of clinical pregnancy rates. 2,34 Considering the spectrum of these antimicrobial agents, lipopolysaccharide derived from Gram-negative bacteria may be a candidate mediator of the pathogenesis in chronic endometritis.…”

Section: Discussionmentioning

confidence: 99%

“…1 Chronic endometritis is frequently identified in women suffering from repeated implantation failure after in vitro fertilization and transfer of morphologically good embryos, as well as abnormal uterine bleeding and pelvic inflammatory disease. [2][3][4] The implantation rates after embryo transfer are significantly lower in the infertile patients with chronic endometritis than in those without chronic endometritis. 2 Chronic endometritis is often overlooked due to its morphological resemblance to secretory phase endometrium.…”

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confidence: 99%

“…[2][3][4] The implantation rates after embryo transfer are significantly lower in the infertile patients with chronic endometritis than in those without chronic endometritis. 2 Chronic endometritis is often overlooked due to its morphological resemblance to secretory phase endometrium. 1 Plasmacytes are sometimes indistinguishable from endometrial stromal fibroblasts by conventional tissue staining methods and localize so focally that they can be missed in small biopsy specimens.…”

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confidence: 99%

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Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis

2010

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Chronic endometritis is often identified in the patients with unexplained infertility, and is histopathologically characterized by infiltration of plasmacytes within the endometrial stroma. In parallel with stromal plasmacyte infiltration, the endometrial functional layer in chronic endometritis is invaded by B cells, which are a rare leukocyte subset residing within the basal layer in the nonpathological endometrium. In this study, we investigated the molecular expression underlying this unusual increase of B cells in chronic endometritis. Twenty-two out of 76 infertile patients were diagnosed with chronic endometritis from the stromal plasmacyte infiltration, and the endometrium contained numerous stromal B-cell aggregates and glandular single B cells. However, the other major leukocyte subsets, including T cells, natural killer cells, macrophages, and neutrophils were comparable in densities in chronic endometritis and nonpathological endometrium. The microvascular endothelium showed immunoreactivity to adhesion molecule selectin E and chemokine CXCL13 along with immunoreactivity to CXCL1 in the glandular epithelium in chronic endometritis, but not in the nonpathological endometrium. Lipopolysaccharide significantly induced surface selectin E expression and CXCL13 secretion in uterine microvascular endothelial cells, and CXCL1 secretion in endometrial epithelial cells in vitro. These findings indicated that the aberrant local microenvironment triggered possibly by bacterial infection has a role in selective extravasation of circulating B cells in chronic endometritis.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis

2010

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“…По мнению большинства авторов, увеличе-ние количества иммунокомпетентных клеток в эндометрии характеризует наличие воспали-тельных процессов в эндометрии и приводит к снижению частоты наступления беремен-ности [21][22][23][24]. При этом одним из ключевых механизмов синхронизированной экспрессии факторов рецептивности является взаимодей-ствие половых стероидных гормонов -эстро-гена и прогестерона -с рецепторами эндо-метрия.…”

Section: Discussionunclassified

Pathogenetic determinants of endometrial dysfunction in patients with myoma

Tolibova

Хайбуллоевна

2018

Z.akus.zen.bolezn

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Introduction. Among the patients with infertility associated with small forms of uterine fibroids (subserous and intra mural), there are a high incidence of inflammatory changes in the cervix, chronic salpingo-opharitis, hydrosalpinx, adhesive process in pelvic organs, chronic endocervicitis and endometrial dysfunction were identified more frequently. The aim of the study was to investigate the clinical and morphological features of endometrial dysfunction in patients with infertility associated with uterine myoma. Material and methods. The study included 165 patients: 70 patients with primary infertility, 65 women with secondary infertility and 30 patients in the control group. All patients were examined and treated in The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott. Laparoscopic and hysteroscopic examination followed by endometrial biopsy was performed on the 19-24th day of the menstrual cycle. Immunohistochemical method was used to study the expression of ER, PR receptors, proinflammatory markers (CD8+, CD20+, CD4+, CD138+), endothelial marker (CD34+) and p16ink4a oncoprotein expression. Estimation of ER and PR expression was carried out by semi-quantitative method of H-Score, other markers, by computer image analysis system “Morphology 5.0” (VideoTest, Russia). Statistical processing of the results was performed using statistical packages (Stata 13). Results. In group of patients with infertility associated with small forms of subserous and intramural uterine myomas, pathognomonic signs of endometrial dysfunction were: high frequency of chronic endometritis, pathological activation of neoangiogenesis, positive expression of inhibitor of cyclin-dependent kinase p16ink4a, reduction of ER and PR expression in the stromal endometrial component, change in receptor affinity of sex steroid hormones.

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“…В ряде ситуаций, когда данные УЗИ не дают возможности однозначно судить о состоянии эндометрия, а позволяют лишь заподозрить его неадекватность или на-личие какой-либо патологии, неэффективность лечения объяснить весьма затруднительно [1,20,30,33]. К таким ситу-ациям можно отнести аденомиоз, ановуляторные состояния при синдроме поликистозных яичников (СПЯ).…”

Section: P%'>% у женщин с трубно-перитонеальной формой бесплодия чаunclassified