Chronic effects of low to moderate alcohol consumption on structural and functional properties of the brain: beneficial or not?

Verbaten, Marinus N.

doi:10.1002/hup.1022

Cited by 45 publications

(34 citation statements)

References 38 publications

(60 reference statements)

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“…We adjusted our analyses for previously described variables (21,22,28) that are potentially confounding or are known to be associated with alcohol consumption or cognitive function (30,31). These included age, education level, and current depression status measured by the short version of the Geriatric Depression Scale, and self-reported overall health status; mid-life body mass index, and systolic blood pressure; and late-life reported smoking status, coronary calcium load measured by computed tomography, high-density lipoprotein cholesterol concentrations, and presence of the apolipoprotein E ε4 allele, a marker for genetic susceptibility to Alzheimer's disease.…”

Section: Measurement Of Covariatesmentioning

confidence: 99%

The Alcohol Paradox: Light-to-Moderate Alcohol Consumption, Cognitive Function, and Brain Volume

Davis

Vidal

García

et al. 2014

The Journals of Gerontology: Series A

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Background. Studies of older persons show consumption of light-to-moderate amounts of alcohol is positively associated with cognitive function and, separately, is negatively associated with total brain volume (TBV). This is paradoxical as generally, cognitive function is positively associated with TBV. We examined the relationships of TBV, global cognitive function (GCF), and alcohol consumption in a population-based cohort of 3,363 men and women (b. 1907-1935) participating in the Age Gene/Environment Susceptibility-Reykjavik Study (2002)(2003)(2004)(2005)(2006) and who were free of dementia or mild cognitive impairment

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Section: Measurement Of Covariatesmentioning

confidence: 99%

The Alcohol Paradox: Light-to-Moderate Alcohol Consumption, Cognitive Function, and Brain Volume

Davis

Vidal

García

et al. 2014

The Journals of Gerontology: Series A

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“…Recent studies show that even moderate alcohol use is associated with brain atrophy despite its cardioprotective effect. 85 …”

Section: Anxiolyticsmentioning

confidence: 99%

Brain Illness and Creativity: Mechanisms and Treatment Risks

Flaherty

2011

Can J Psychiatry

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Highlights • Psychiatric and neurological drug choice may alter patients' creativity, sometimes in counterintuitive ways. • To preserve creativity, treatments that enhance dopaminergic function are more helpful than those that decrease dopaminergic function. • Traits that in stressful environments increase vulnerability to illness may, in permissive environments, help creativity. Brain diseases and their treatment may help or hurt creativity in ways that shape quality of life. Increased creative drive is associated with bipolar disorder, depression, psychosis, temporal lobe epilepsy, frontotemporal dementia, Parkinson disease treatments, and autism. Creativity depends on goal-driven approach motivation from midbrain dopaminergic systems. Fear-driven avoidance motivation is of less aid to creativity. When serotonin and norepinephrine lower motivation and flexible behaviour, they can inhibit creativity. Hemispheric lateralization and frontotemporal connections must interact to create new ideas and conceptual schemes. The right brain and temporal lobe contribute skill in novelty detection, while the left brain and frontal lobe foster approach motivation and more easily generate new patterns of action from the novel perceptions. Genes and phenotypes that increase plasticity and creativity in tolerant environments with relaxed selection pressure may confer risk in rigorous environments. Few papers substantively address this important but fraught topic. Antidepressants (ADs) that inhibit fear-driven motivation, such as selective serotonin reuptake inhibitors, sometimes inhibit goal-oriented motivation as well. ADs that boost goal-directed motivation, such as bupropion, may remediate this effect. Benzodiazepines and alcohol may be counterproductive. Although dopaminergic agonists sometimes stimulate creativity, their doing so may inappropriately disinhibit behaviour. Dopamine antagonists may suppress creative motivation; lithium and anticonvulsant mood stabilizers may do so less. Physical exercise and REM sleep may help creativity. Art therapy and psychotherapy are not well studied. Preserving creative motivation can help creativity and other aspects of well-being in all patients, not just artists or researchers.

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“…For example, alcoholism has consistently been shown to cause significant decreases in both grey and white matter volumes, as well as increases in sulcal and ventricular volumes, with the amount of loss accelerated with age (Pfefferbaum et al, 1992;Pfefferbaum et al, 1997;Verbaten, 2009). …”

Section: Introductionmentioning

confidence: 96%

Neural impact of low-level alcohol use on response inhibition: An fMRI investigation in young adults

Hatchard

Mioduszewski

Fall

et al. 2017

Behavioural Brain Research

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Chronic effects of low to moderate alcohol consumption on structural and functional properties of the brain: beneficial or not?

Cited by 45 publications

References 38 publications

The Alcohol Paradox: Light-to-Moderate Alcohol Consumption, Cognitive Function, and Brain Volume

The Alcohol Paradox: Light-to-Moderate Alcohol Consumption, Cognitive Function, and Brain Volume

Brain Illness and Creativity: Mechanisms and Treatment Risks

Neural impact of low-level alcohol use on response inhibition: An fMRI investigation in young adults

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