Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.

McConnell, Ernest E.; Shefner, Alan M.; Rust, John H.; Moore, J. A.

doi:10.1289/ehp.835311

Cited by 17 publications

(8 citation statements)

References 11 publications

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“…The best available technology for determining asbestos content in water is described in a 1983 EPA project report (20 (29,30). All of these studies used animals reared from dams exposed to the asbestos fibers.…”

Section: Recommended Sampling Methods For Detecting Asbestos Fibers Inmentioning

confidence: 99%

Report on cancer risks associated with the ingestion of asbestos. DHHS Committee to Coordinate Environmental and Related Programs

1987

Environ Health Perspect

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This report is an assessment of all available literature that pertains to the potential risk of cancer associated with ingestion of asbestos. It was compiled by a working group to assist policy makers in the Department of Health and Human Services determine if adequate information was available for a definitive risk assessment on this potential problem and evaluate if the weight of evidence was sufficient to prioritize this issue for new policy recommendations. The work group considered the basis for concern over this problem, the body of toxicology experiments, the individual epidemiologic studies which have attempted to investigate this issue, and the articles that discuss components of risk assessment pertaining to the ingestion of asbestos. In the report, the work group concluded: 1) that no direct, definitive risk assessment can be conducted at this time; 2) that further epidemiologic investigations will be very costly and only possess sufficient statistical power to detect relatively large excesses in cancers related to asbestos ingestion; and 3) that probably the most pertinent toxicologic experiments relate to resolving the differences in how inhaled asbestos, which is eventually swallowed, is biologically processed by humans, compared to how ingested asbestos is processed. The work group believes that the cancer risk associated with asbestos ingestion should not be perceived as one of the most pressing potential public health hazards facing the nation. However, the work group does not believe that information was sufficient to assess the level of cancer risks associated with the ingestion and therefore, this potential hazard should not be discounted, and ingestion exposure to asbestos should be eliminated whenever possible.

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Section: Recommended Sampling Methods For Detecting Asbestos Fibers Inmentioning

confidence: 99%

Report on cancer risks associated with the ingestion of asbestos. DHHS Committee to Coordinate Environmental and Related Programs

1987

Environ Health Perspect

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show abstract

“…For more details about the full method and the rapid method, the reader is referred to the EPA report. Toxicology To date, 11 toxicologic studies on asbestos ingestion have been conducted (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Eight of these studies have been reviewed by Condie (32), who concluded that the studies do not provide substantive support for an association between ingestion of asbestos fibers and the induction of cancer.…”

Section: Recommended Sampling Methods For Detecting Asbestos Fibers Inmentioning

confidence: 99%

“…Two recent reports from the National Toxicology Program (NTP) have shown no carcinogenic response after lifetime exposure of Syrian golden hamsters to 1% amosite or chrysotile asbestos in the diet and in F344 rats which were fed 1% amosite or tremolite in their diet during a lifetime study (29,30). All of these studies used animals reared from dams exposed to the asbestos fibers.…”

Section: Recommended Sampling Methods For Detecting Asbestos Fibers Inmentioning

confidence: 99%

Report on cancer risks associated with the ingestion of asbestos. DHHS Committee to Coordinate Environmental and Related Programs.

1987

Environ Health Perspect

View full text Add to dashboard Cite

This report is an assessment of all available literature that pertains to the potential risk of cancer associated with ingestion of asbestos. It was compiled by a working group to assist policy makers in the Department of Health and Human Services determine if adequate information was available for a definitive risk assessment on this potential problem and evaluate if the weight of evidence was sufficient to prioritize this issue for new policy recommendations. The work group considered the basis for concern over this problem, the body of toxicology experiments, the individual epidemiologic studies which have attempted to investigate this issue, and the articles that discuss components of risk assessment pertaining to the ingestion of asbestos. In the report, the work group concluded: that no direct, definitive risk assessment can be conducted at this time; that further epidemiologic investigations will be very costly and only possess sufficient statistical power to detect relatively large excesses in cancers related to asbestos ingestion; and that probably the most pertinent toxicologic experiments relate to resolving the differences in how inhaled asbestos, which is eventually swallowed, is biologically processed by humans, compared to how ingested asbestos is processed. The work group believes that the cancer risk associated with asbestos ingestion should not be perceived as one of the most pressing potential public health hazards facing the nation. However, the work group does not believe that information was sufficient to assess the level of cancer risk associated with the ingestion and therefore, this potential hazard should not be discounted, and ingestion exposure to asbestos should be eliminated whenever possible.

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“…In vivo intestinal permeability studies with long term ingested chrysotile in the drinking water (0.5 g/L), absorptional ability of non-metabolizable sugars was decreased in GIT [74]. But, McConnell group showed that toxic or neoplastic lesions are not observed in gastrointestinal tract and mesothelium in Fischer 344 rat and in Syrian golden hamsters given the diet with amosite (at a concentration of 1% of pelleted diet) for their lifetime even though increasing C-cell carcinomas of the thyroid and monocyte significantly [75,76]. …”

Section: Mechanism Study Of Gi Cancer By Asbestosmentioning

confidence: 99%

Asbestos-Induced Gastrointestinal Cancer: An Update

Kim

Williams

Cheresh

et al. 2013

J Gastrointest Dig Syst

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Asbestos-related diseases, such as malignancies and asbestosis, remain a significant occupational and public health concern. Asbestos is still widely used in many developing countries despite being a recognized carcinogen that has been banned over 50 countries. The prevalence and mortality from asbestos-related diseases continue to pose challenges worldwide. Many countries are now experiencing an epidemic of asbestos-related disease that is the legacy of occupational exposure during the 20th century because of the long latency period (up to 40 years) between initial asbestos exposure and exhibition of disease. However, the gastrointestinal (GI) cancers resulting from asbestos exposure are not as clearly defined. In this review, we summarize some of the recent epidemiology of asbestos-related diseases and then focus on the evidence implicating asbestos in causing GI malignancies. We also briefly review the important new pathogenic information that has emerged over the past several years that may account for asbestos-related gastrointestinal cancers. All types of asbestos fibers have been implicated in the mortality and morbidity from GI malignancies but the collective evidence to date is mixed. Although the molecular basis of GI cancers arising from asbestos exposure is unclear, there have been significant advances in our understanding of mesothelioma and asbestosis that may contribute to the pathophysiology underlying asbestos-induced GI cancers. The emerging new evidence into the pathogenesis of asbestos toxicity is providing insights into the molecular basis for developing novel therapeutic strategies for asbestos-related diseases in future management.

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Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.

Cited by 17 publications

References 11 publications

Report on cancer risks associated with the ingestion of asbestos. DHHS Committee to Coordinate Environmental and Related Programs

Report on cancer risks associated with the ingestion of asbestos. DHHS Committee to Coordinate Environmental and Related Programs

Report on cancer risks associated with the ingestion of asbestos. DHHS Committee to Coordinate Environmental and Related Programs.

Asbestos-Induced Gastrointestinal Cancer: An Update

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