Chronic effects of copper and zinc on the fish, Etroplus suratensis (Bloch, 1790) by continuous flow through (CFT) bioassay

Xavier, N.D. Don; Nandan, S. Bijoy; Jayachandran, P. R.; Anu, P.R.; Midhun, A.M.; Mohan, D.

doi:10.1016/j.marenvres.2018.11.002

Cited by 30 publications

(5 citation statements)

References 60 publications

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“…This was also found in a study where Astyanax aff. bimaculatus was exposed to higher concentrations of zinc [101], and was also noted in cichlid fish (Etroplus suratensis), upon exposure to zinc [87]. This is most likely a consequence of disrupted calcium homeostasis [102] as a direct consequence of competition at the uptake site, the epithelial calcium channel, or because of influence of zinc on the cellular Ca 2+ signaling [103,104,105], although we did not measure significant drops in gill calcium levels here.…”

Section: Plos Onementioning

confidence: 81%

“…Partial lamellar fusion in the form of fused tips of secondary lamellae was more common. Partial or even complete lamellar fusion of lamellae has been detected before under copper exposure, however mostly at much higher copper concentrations [86,87,88,89,90], and could compromise respiration. Hypertrophy of secondary lamellae and their tips occurred in the Cu 50 group in a very similar way to what was seen in common carp exposed to 1.72 μM copper [15].…”

Section: Plos Onementioning

confidence: 98%

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Toxicity and bioaccumulation of Cadmium, Copper and Zinc in a direct comparison at equitoxic concentrations in common carp (Cyprinus carpio) juveniles

et al. 2020

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The individual toxicity and bioaccumulation of cadmium, copper and zinc for common carp juveniles was evaluated in a direct comparison in two experimental setups. First, fish were exposed for 10 days to different metal concentrations in order to link metal bioaccumulation to LC 50 values (concentration lethal to 50% of the animals) and incipient lethal levels (ILL, concentration where 50% survives indefinitely). Accumulated metals showed a positive dose dependent uptake for cadmium and copper, but not for zinc. Toxicity was in the order cadmium>copper>zinc with 96h LC 50 values for cadmium at 0.20±0.16 μM, for copper at 0.77±0.03 μM, and for zinc at 29.89±9.03 μM respectively. For copper, the 96h exposure was sufficient to calculate the incipient lethal level and therefore 96h LC 50 and ILL levels were the same, while for cadmium and zinc 5 to 6 days were needed to reach ILL resulting in slightly lower values at 0.16 μM and 28.33 μM respectively. Subsequently, a subacute exposure experiment was conducted, where carp juveniles were exposed to 2 equitoxic concentrations (10% and 50% of LC 50 96 h) of the three metals for 1, 3 and 7 days. Again a significant dose-dependent increase in gill cadmium and copper, but not in zinc, was observed during the 7-day exposure. Copper clearly affected sodium levels in gill tissue, while zinc and cadmium did not significantly alter any of the gill electrolytes. The overall histopathological effects (e.g. hyperemia and hypertrophy) of the metal exposures were mild for most of the alterations. Our study showed that copper an cadmium (but not zinc) showed dose dependent metal accumulation, however this bioaccumulation was only correlated with mortality for cadmium. Metal specific alterations were reduced gill sodium levels in copper exposed fish and oedema of the primary epithelium which typically occurred in both levels of zinc exposure.

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Section: Plos Onementioning

confidence: 81%

Section: Plos Onementioning

confidence: 98%

Toxicity and bioaccumulation of Cadmium, Copper and Zinc in a direct comparison at equitoxic concentrations in common carp (Cyprinus carpio) juveniles

et al. 2020

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“…In addition, SEM models showed that metal bioaccumulation was related to the increased N/L inflammatory immune ratio, partly due to increased neutrophils number, which suggests that trace metals triggered a significant over-inflammation (Dethloff et al, 1999;Don Xavier et al, 2019), which in turn may increase liver cellular lesions. Indeed, histopathological analyses reveal an increase of biliary alteration and hepatic fibrosis, which are likely to reflect chronic cytotoxicity, overinflammation and more globally liver alteration (Lukin et al, 2011;Wolf and Wolfe, 2005).…”

Section: Effects Of Contamination Gradientmentioning

confidence: 99%

Direct and indirect effects of multiple environmental stressors on fish health in human-altered rivers

Petitjean

Jean

Côte

et al. 2020

Science of The Total Environment

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Freshwater fish face multiple challenges in human-altered rivers such as trace metal contamination, temperature increase and parasitism. These multiple stressors could have unexpected interactive effects on fish health due to shared physiological pathways, but few studies investigated this question in wild fish populations. In this study, we compared 16 populations of gudgeon (Gobio occitaniae) distributed along perturbation gradients in humanaltered rivers in the South of France. We tested the effects of single and combined stressors (i.e., metal contamination, temperature, parasitism) on key traits linked to fish health across different biological levels using a Structural Equation Modelling approach. Parasitism and temperature alone had limited deleterious effects on fish health. In contrast, fish living in metal-contaminated sites had higher metal bioaccumulation and higher levels of cellular damage in the liver through the induction of an inflammatory response. In addition, temperature and contamination had interactive negative effects on growth. These results suggest that trace metal contamination has deleterious effects on fish health at environmentally realistic concentrations and that temperature can modulate the effects of trace metals on fish growth. With this study, we hope to encourage integrative approaches in realistic field conditions to better predict the effects of natural and anthropogenic stressors on aquatic organisms.

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“…Stimulated by inflammation, it induces hyperplasia of megakaryocytes, which in turn interacts with endothelial cells and white blood cells to produce inflammatory factors in a vicious cycle. The occurrence of various diseases is associated with increased platelets [ 39 , 40 ]. NLR is a novel inflammatory factor that plays a great role in the development of coronary heart disease, myocardial infarction and tumors [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Combined evaluation of Geriatric nutritional risk index and Neutrophil to lymphocyte ratio for predicting all-cause and cardiovascular mortality in hemodialysis patients

Huang

et al. 2023

PLoS ONE

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Objective Malnutrition, accompanied by an inflammatory profile, is a risk factor for poor prognosis in hemodialysis patients. The purpose of this study was to investigate the predictive value of NLR combined with GNRI for all-cause and cardiovascular mortality in hemodialysis patients. Methods A total of 240 maintenance hemodialysis (MHD) patients in hemodialysis centers were enrolled in this retrospective study. The influencing factors of all-cause death in hemodialysis patients were analyzed by COX regression. The cut-off values of GNRI and NLR for predicting mortality in enrolled MHD patients were 89.01 and 4, respectively. Based on these cut-off values, the patients were divided into four groups: G1: high GNRI (≥ 89.01) + high NLR (≥ 4) group; G2: high GNRI (≥ 89.01) + low NLR (<4) group, G3: low GNRI (< 89.01) + high NLR (≥4) group; G4: low GNRI (< 89.01) + low NLR (<4). Results During the follow-up period (average: 58 months), the all-cause mortality was 20.83%(50/240) and the cardiovascular mortality was 12.08%(29/240). Both NLR and GNRI were independent risk factors for the prognosis of MHD patients (P<0.05). Survival analysis showed that patients with low GNRI had a lower survival rate than those with high GNRI, whereas patients with high NLR had a lower survival rate than those with low NLR. Kaplan-Meier curve for all-cause mortality revealed that compared to G1, G2, and G4, G3 had the lowest survival rate, while G2 had the highest survival rate among all groups (P < 0.05). Kaplan-Meier curve for cardiovascular mortality showed that G3 had lower survival than G1, G2, and G4 (P < 0.001). Conclusions Our study demonstrates that bothGNRI and NLR are associated with all-cause mortality and cardiovascular mortality in MHD patients. Combining these two factorsmay contribute to a prognostic evaluation for MHD patients.

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Chronic effects of copper and zinc on the fish, Etroplus suratensis (Bloch, 1790) by continuous flow through (CFT) bioassay

Cited by 30 publications

References 60 publications

Toxicity and bioaccumulation of Cadmium, Copper and Zinc in a direct comparison at equitoxic concentrations in common carp (Cyprinus carpio) juveniles

Toxicity and bioaccumulation of Cadmium, Copper and Zinc in a direct comparison at equitoxic concentrations in common carp (Cyprinus carpio) juveniles

Direct and indirect effects of multiple environmental stressors on fish health in human-altered rivers

Combined evaluation of Geriatric nutritional risk index and Neutrophil to lymphocyte ratio for predicting all-cause and cardiovascular mortality in hemodialysis patients

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