Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague–Dawley rats

Butenhoff, John L.; Kennedy, Gerald L.; Chang, Shu‐Ching; Olsen, Geary W.

doi:10.1016/j.tox.2012.04.001

Cited by 60 publications

(100 citation statements)

References 39 publications

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“…The toxicity profiles of PFOS and PFOA in vitro and in animals are slowly being refined [100,110,192,[215][216][217][218][219][220]. Acute toxicity of PFAAs is generally low and decreases with decreasing Fchain length.…”

Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 99%

“…Chronic carcinogenicity studies in rats found low incidences of benign hepatocellular, Leydig cell of the testis and pancreatic acinar cell adenomas for APFO at high doses [216,258], and an increased incidence of hepatocellular adenomas, but no kidney or bladder effects with PFOS (K + ) [215]. Little or no information is available for other long-F-chain PFASs.…”

Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 99%

See 1 more Smart Citation

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

229

122

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Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 99%

Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 99%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

229

122

View full text Add to dashboard Cite

“…The choice of the strain was never discussed in scientific publications as required by EFSA. Only Butenhoff et al [41] deliberated on the characteristics of SD rats in the context of comparing their results with studies using other strains. Only Liang et al [49] applied a blinded evaluation in their histological analysis as asked for by EFSA.…”

Section: Comparative Analysis Of Other Long-term Rat Feeding Studiesmentioning

confidence: 99%

“…Only Liang et al [49] applied a blinded evaluation in their histological analysis as asked for by EFSA. Butenhoff et al [41] had chosen a blinded evaluation for their re-assessment of existing histopathological probes. None of the 21 studies reported about storage conditions or presented power calculations.…”

Section: Comparative Analysis Of Other Long-term Rat Feeding Studiesmentioning

confidence: 99%

Rat feeding studies with genetically modified maize - a comparative evaluation of applied methods and risk assessment standards

Meyer¹,

Hilbeck²

2013

Environ Sci Eur

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A 2-year rat feeding study with genetically modified NK603 maize sparked an international scientific and public debate as well as policy responses by the European Commission. The European Food Safety Authority (EFSA) evaluated the study as defective based on conceptual and methodological shortcomings by retroactive application of the recommendations of its recent guidance on 90-day feeding studies. Our comparative analysis of the three relevant NK603 publications, including a 90-day feeding study of Monsanto, showed that all of them satisfy or fail to satisfy the EFSA evaluation criteria to a comparable extent; the rejection of only one of the papers is, thus, not scientifically justified. We also show that EFSA's criteria are not standard practice in 21 other rat feeding studies lasting at a minimum of 12 months. The review reveals critical double standards in the evaluation of feeding studies submitted as proof of safety for regulatory approval to EFSA. We specifically argue that the current approach to declare statistically significant differences between genetically modified organisms and its parents as 'biologically irrelevant' based on additional reference controls lacks scientific rigor and legal justification in the European Union (EU) system. Only recently, the EU authorities started building up an implementing system based on its own legislation and supportive of the EU approach to risk assessment in the context of technology assessment. Until these issues are resolved, we do not expect that neither the public nor the scientific debate will subside.

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“…Similarly, the NOAEL levels for systemic toxicity in male and female rats for PFHxA in the chronic study [24•] were 15 and 30 mg/kg/day, respectively, whereas the bioassay conducted with ammonium PFOA in rats noted liver damage in treated rats down to the lowest dose tested of 1.5 mg/kg/day [47]. In contrast, both the 90-day study conducted with the C6-FTOH [36••] and an oral 90-day study conducted with the C8 fluorotelomer alcohol (8-2 FTOH) [48] reported NOAELs of 5 mg/kg/day for systemic toxicity, indicating that decreased perfluorinated chain length of the FTOH did not decrease the toxic potency under the test conditions in short-term studies.…”

Section: Systemic and Reproductive Toxicologymentioning

confidence: 99%

C6-Perfluorinated Compounds: The New Greaseproofing Agents in Food Packaging

Rice

2015

Curr Envir Health Rpt

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Due to their oleophobic and hydrophobic properties and stability, perfluorinated compounds (PFCs) are used in many applications, particularly as greaseproofing agents for food contact. However, PFCs 8-carbons in length or greater (C8-PFCs) have raised concerns regarding environmental biopersistence, bioaccumulation in humans, and potent toxicity that have resulted in their gradual phase-out for food contact use. Industry has replaced C8-PFCs with shorter-chained C6-based greaseproofing agents, which are intended to have the same favorable physicochemical properties without the problematic toxicological effects in humans and wildlife. Compared with the large body of data available for C8 compounds, however, the available database on toxicity and exposure to the C6 compounds is fairly limited. This article summarizes the information in this database, focusing on aspects of human exposure and potential health risks associated with two types of C6 PFCs found in food packaging: perfluorohexanoic acid (PFHxA) and 6-2 fluorotelomer alcohol (C6-FTOH).

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Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague–Dawley rats

Cited by 60 publications

References 39 publications

Per- and polyfluorinated substances (PFASs): Environmental challenges

Per- and polyfluorinated substances (PFASs): Environmental challenges

Rat feeding studies with genetically modified maize - a comparative evaluation of applied methods and risk assessment standards

C6-Perfluorinated Compounds: The New Greaseproofing Agents in Food Packaging

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