Chronic demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in peripheral T-cell lymphoma

Abstract

Malignant lymphoma can cause peripheral neuropathy through various mechanisms. We report the case of 67-year-old man with chronic motor and sensory axonal demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in serum and cerebrospinal fl uid (CSF) as an initial presentation of peripheral T-cell lymphoma, not otherwise specifi ed. The patient was treated with chemotherapy for T-cell lymphoma, and achieved complete remission. Motor function recovered completely and sensory function improved. Neurological improvement was concurrent with the disappearance of serum and CSF antiganglioside GQ1b antibodies. This is the fi rst report of chronic demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in peripheral T-cell lymphoma.

Inflammatory neuropathy with evidence of anti-GQ1b antibodies in angioimmunoblastic T cell lymphoma (AITL): a case report

“…In particular, disease courses involving ophthalmoparesis are associated with GQ1b antibodies—but cranial nerve palsies were not present in our patient at any time. However, one case report has been published concerning a patient with CIDP-like symptoms and positive GQ1b antibodies in T cell lymphoma [ 13 ] and another on two patients with positive GQ1b antibodies, CIDP-like symptoms and IgM paraproteins [ 14 ].…”