Chronic Critical Illness-Induced Muscle Atrophy: Insights From a Trauma Mouse Model and Potential Mechanism Mediated via Serum Amyloid A
Mingxing Lei,
Taojin Feng,
Mingming Zhang
et al.
Abstract:Background
Chronic critical illness (CCI), which was characterized by persistent inflammation, immunosuppression, and catabolism syndrome (PICS), often leads to muscle atrophy. Serum amyloid A (SAA), a protein upregulated in critical illness myopathy, may play a crucial role in these processes. However, the effects of SAA on muscle atrophy in PICS require further investigation. This study aims to develop a mouse model of PICS combined with bone trauma to investigate the mechanisms underlying muscle… Show more
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