Chronic consumption of three forms of palm oil diets alters glomerular filtration rate and renal plasma flow

Abstract

The effects of chronic consumption of three types of palm oil diets on glomerular filtration rate (GFR), renal plasma flow (RPF) and blood pressure were studied. Wistar rats were randomly assigned into four groups of ten rats each, respectively: control, fresh (FPO), photoxidized (PPO), thermoxidized (TPO) palm oil diet-fed rats. The control group was fed rat chow only, while experimental groups had different palm oil diets at 15% wt/wt for twelve weeks and tap water ad libitum. After the feeding period, GFR, RPF, systolic and diastolic blood pressures were measured. GFR and RPF of the TPO (0.07 ± 0.01 ml/min and 1.50 ± 0.24 ml/min) and PPO (0.14 ± 0.01 and 2.54 ± 0.11) groups were significantly (p < 0.001) reduced compared with control (0.77 ± 0.04 and 5.3 ± 0.30) and FPO (0.81 ± 0.02 and 4.8 ± 0.13) groups. The GFR and RPF of the TPO group was significantly (p < 0.05) higher than that of the PPO group. Systolic and diastolic blood pressures of the TPO group (140 ± 3 mmHg and 106 ± 4 mmHg) were significantly (p < 0.01) increased when compared with the control (112 ± 6.4 and 78 ± 5), FPO (118 ± 5 and 81 ± 6) and PPO (122 ± 5 and 89 ± 5) groups. These results suggest that chronic consumption of TPO and PPO caused a decrease in GFR and RPF, but increased blood pressure in rats, while FPO did not adversely affect blood pressure, GFR and RPF.

The subacute toxicity effects of aged Tualang (Koompassia excelsa) honey with high 5-hydroxymethylfurfural content in rats

“…In general, there was a connection between the changes in the kidney histology which attributed to the increase in the kidney weight and creatinine elevation. As kidney is the vital organ for the excretion of harmful products, it is also vulnerable to oxidative stress resulting from the imbalance between reactive oxygen species and defence mechanisms (Beshel et al, 2014). Nevertheless, the liver of all treated rats did not demonstrate any bizarre changes which indicated a good sign of the absence of toxicity.…”

Chronic Consumption of Open Market “Fresh” Palm Oil Alters Renal Handling of Na+, Cl, K+ and HCO3-

“…The concentration of Na + and Clin the urine of FPO market and PPO were also high compared with the control and FPO mill groups. Previous studies have shown that chronic consumption of oxidized palm oil results in the destruction of the hemopoeitic system [19], liver, and kidneys [3] and reduce glomerular filtation as well as renal blood flow [20]. Also [21] stated that acute kidney injury may also lead to a reduction of urine Na + concentration.…”

Comparative effects of fresh palm oil and vitamin E on lipid profile in thermo-oxidized palm oil fed albino rat

“…The palm oil was shared into two black ten liters container to avoid oxidation; one container was FPO, the other container was thermally oxidized to yield TPO. Thermo-oxidation of oil was done following Beshel et al, [11] method, which involved heating FPO at 150 °C for 20 minutes at an interval of five and a cooling period of 5 hours prior to commencing the next round of heating in a stainlesssteel pot. According to Obembe et al, [12] the FPO and TPO diets were made by combining 15 g of each oil with 85 g of rat feed.…”