Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression

Liu, Qiong; Zhu, Haiyan; Li, Bing; Wang, Yan-Qing; Yu, Jin; Wu, Gen-Cheng

doi:10.1016/j.jad.2012.03.018

Cited by 50 publications

(33 citation statements)

References 36 publications

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“…While inhibiting NGF and FGF-2 expression, it has been reported that exposure to chronic stress upregulated NT-3 and GDNF [26, 27]. However, the results were inconsistent [28, 29]. In our study, we confirmed the increase of NT-3 and GDNF, which suggests a compensatory adaptive process to the stress-induced alterations of neurotrophic signaling in the hippocampus.…”

Section: Discussionsupporting

confidence: 82%

The Impacts of Swimming Exercise on Hippocampal Expression of Neurotrophic Factors in Rats Exposed to Chronic Unpredictable Mild Stress

Jiang

Dang

Huan-de

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Depression is associated with stress-induced neural atrophy in limbic brain regions, whereas exercise has antidepressant effects as well as increasing hippocampal synaptic plasticity by strengthening neurogenesis, metabolism, and vascular function. A key mechanism mediating these broad benefits of exercise on the brain is induction of neurotrophic factors, which instruct downstream structural and functional changes. To systematically evaluate the potential neurotrophic factors that were involved in the antidepressive effects of exercise, in this study, we assessed the effects of swimming exercise on hippocampal mRNA expression of several classes of the growth factors (BDNF, GDNF, NGF, NT-3, FGF2, VEGF, and IGF-1) and peptides (VGF and NPY) in rats exposed to chronic unpredictable mild stress (CUMS). Our study demonstrated that the swimming training paradigm significantly induced the expression of BDNF and BDNF-regulated peptides (VGF and NPY) and restored their stress-induced downregulation. Additionally, the exercise protocol also increased the antiapoptotic Bcl-xl expression and normalized the CUMS mediated induction of proapoptotic Bax mRNA level. Overall, our data suggest that swimming exercise has antidepressant effects, increasing the resistance to the neural damage caused by CUMS, and both BDNF and its downstream neurotrophic peptides may exert a major function in the exercise related adaptive processes to CUMS.

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Section: Discussionsupporting

confidence: 82%

The Impacts of Swimming Exercise on Hippocampal Expression of Neurotrophic Factors in Rats Exposed to Chronic Unpredictable Mild Stress

Jiang

Dang

Huan-de

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Preclinical evidence indicates that animals exposed to chronic unpredictable stress (CUS) - a model for depression, exhibit depression-like behavior, and decrease in GDNF expression in their hippocampus (Liu et al, 2012). Interestingly, chronic tricyclic antidepressant treatment helps to reverse depression-like behavior and restores hippocampal GDNF expression to normal (Liu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, chronic tricyclic antidepressant treatment helps to reverse depression-like behavior and restores hippocampal GDNF expression to normal (Liu et al, 2012). The role of GDNF in the pathophysiology of MDD has also been investigated in human studies.…”

Section: Introductionmentioning

confidence: 99%

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Sharma

Silva

Soares

et al. 2016

Journal of Affective Disorders

116

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Rationale The neurotrophin hypothesis of major depressive disorder (MDD) postulates that this illness results from aberrant neurogenesis in brain regions that regulates emotion and memory. Notwithstanding this theory has primarily implicated BDNF in the neurobiology of MDD. Recent evidence suggests that other trophic factors namely GDNF, VEGF and IGF-1 may also be involved. Purpose The present review aimed to critically summarize evidence regarding changes in GDNF, IGF-1 and VEGF in individuals with MDD compared to healthy controls. In addition, we also evaluated the role of these mediators as potential treatment response biomarkers for MDD. Methods A comprehensive review of original studies studies measuring peripheral, central or mRNA levels of GDNF, IGF-1 or VEGF in patients with MDD was conducted. The PubMed/MEDLINE database was searched for peer-reviewed studies published in English through June 2nd, 2015. Results Most studies reported a reduction in peripheral GDNF and its mRNA levels in MDD patients versus controls. In contrast, IGF-1 levels in MDD patients compared to controls were discrepant across studies. Finally, most studies reported high peripheral VEGF levels and mRNA expression in MDD patients compared to healthy controls. Conclusions GDNF, IGF-1 and VEGF levels and their mRNA expression appear to be differentially altered in MDD patients compared to healthy individuals, indicating that these molecules might play an important role in the pathophysiology of depression and antidepressant action of therapeutic interventions.

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“…In rodents repeatedly exposed to social defeat, there is a decrease in volume and cell proliferation in the hippocampus that can be reversed by chronic antidepressant treatment (Czéh et al 2007, Becker et al 2008, Van Bokhoven et al 2011). Clomipramine, a tricyclic antidepressant widely used to treat depression and obsessive compulsive disorder, has been shown to reverse the behavioral deficits and inhibition of cell proliferation in the adult hippocampus induced by chronic unpredictable stress (Liu et al 2008(Liu et al , 2012.…”

Section: Introductionmentioning

confidence: 99%

Effects of social stress and clomipramine on emotional memory in mice

Duque¹,

Vinader‐Caerols²,

Monleón³

2016

Acta Neurobiologiae Experimentalis

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We have previously observed impairing effects of social defeat stress (CSDS) on inhibitory avoidance (IA) in mice. Given the similarity between changes produced by social stress in animals and symptoms of certain human psychopathologies such as depression and anxiety, the effects of the antidepressant clomipramine on IA impairment produced by CSDS were evaluated in the present study.Male CD1 mice were randomly assigned to the groups: non-stressed+saline, non-stressed+clomipramine, stressed+saline and stressed+clomipramine. Stressed animals were subjected to daily agonistic encounters (10 min) in the home cage of the aggressor over a 20-day period. Just before each encounter, non-stressed and stressed mice were injected i.p. with saline or clomipramine (10 mg/kg) according to their experimental condition. 24 hours after the last CSDS session, all the mice were tested in a step-through IA task. In the IA training phase, animals were punished by a shock to the paw when they entered the dark compartment of the apparatus. In the IA test phase (one week later) the same procedure took place, but without shock. Complementary measures were obtained by evaluating all the animals in an elevated plus maze (locomotor activity and emotionality) and on a hot plate (analgesia). IA learning was confirmed in all groups except the stressed+saline group, which was the only one that exhibited higher anxiety levels. No variations were observed in either locomotor activity or analgesia. In conclusion, CSDS induces anxiety and impairs emotional memory in mice; the negative effects of CSDS on memory appear to be attenuated by clomipramine, and these detrimental effects do not seem to be secondary to the effects of CSDS on locomotor activity, emotionality or pain sensitivity.

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Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression

Cited by 50 publications

References 36 publications

The Impacts of Swimming Exercise on Hippocampal Expression of Neurotrophic Factors in Rats Exposed to Chronic Unpredictable Mild Stress

The Impacts of Swimming Exercise on Hippocampal Expression of Neurotrophic Factors in Rats Exposed to Chronic Unpredictable Mild Stress

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Effects of social stress and clomipramine on emotional memory in mice

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