Chronic chlorpromazine administration: Some pharmacological and psychological effects in man

A Behavioral and Autonomic Nervous System Study of RO-5-3350 and Diazepam in Conscious Dogs

“…Also, the qualitative nature of the pharmacological response can be dif ferent when different dosage durations are employed and when conscious versus anesthetized animals are utilized. Long et al [13] in animals and Sletten et al [17] in man reported that the chronic administration of chlorpromazine produced a change in the profile of autonomic nervous system and behavioral rating scale effects which in time was similar to that obtained following acute treat ment with imipramine. Schneider and Rinehart [16] reported that the alkaloid ibogaine has profound blood pressure effects in an esthetized animals but not in the conscious preparation.…”

A Behavioral and Autonomic Nervous Sytem Study of Chronic Imipramine Administration to Conscious Dogs

“…The pharmacological response can be different when different dosage durations are employed and when conscious rather than anesthetized preparations are utilized. Lang et al ( 13), in animals, and Sletten et al (18), in man, reported that the chronic administration of chlorpromazine produced a change in the profile of autonomic nervous system and be havioral rating scale effects which in time was similar to that obtained following acute treat ment with imipramine. Schneider and Rinehart (16) reported that the alkaloid, ibogaine, has profound blood pressure effects in anesthetized animals, but seems to be ineffectual in the conscious preparation.…”

Some Pharmacological Effects of a New Potential Antidepressant Cyprolidol (IN 1060) Compared with Imipramine

“…These compounds are related struc turally to the phenothiazine-tvpe tranquilizers and have many similar pharma cological actions. Pharmacological studies in animals (15) and in man (27) demonstrated that the chronic administration of chlorpromazine (CPZ) pro duced a profile of autonomic nervous system and behavioral rating scale effects quite similar to that obtained with imipramine. These studies support dis cussions by Overall et al (22) and Hollister (10) that both the iminodibenzyl and the phenothiazine compounds administered chronically may have similar clinical efficacy in the treatment of depression.…”