Chronic Chlamydia pneumoniae infection in patients with symptomatic atherothrombosis

Halfon, Philippe; Limal, N.; Pénaranda, Guillaume; Khiri, H.; Sène, Damien; Andreu, Marita; Feryn, Jean Marc; Rotily, Michel; Serra, Raffaele; Pietté, J.C.; Cacoub, Patrice

doi:10.1016/j.jinf.2005.10.027

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Thus, C. pneumoniae can induce a persistent infection due to the inability of the host to completely eliminate the pathogen (Yucesan and Sriram, 2001;Stratton and Sriram, 2003). For this reason, C. pneumoniae has recently been connected to a range of chronic systemic diseases which are characterized by inflammation and scarring with a subsequent significant tissue damage including chronic inflammatory lung conditions, such as asthma and chronic obstructive pulmonary disease (Blasi, 2004;Teig et al, 2005), inflammatory arthritis (Gerard et al, 2000) as well as cardiovascular and peripheral vascular diseases (Mussa et al, 2006;Halfon et al, 2006). However, although evidence exists for a direct role of C. pneumoniae in atherogenesis (Campbell and Kuo, 2004), the actual involvement of this pathogen in atherosclerosis still remains to be confirmed (Ieven and Hoymans, 2005).…”

Section: Chlamydia Pneumoniae As Putative Candidate For Msmentioning

confidence: 99%

Under the Microscope: Focus on Chlamydia pneumoniae Infection and Multiple Sclerosis

Fainardi¹,

Castellazzi²,

Seraceni³

et al. 2008

CNR

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Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the Central Nervous System (CNS) of supposed autoimmune origin whose etiology still remains unknown. Epidemiological studies suggest that MS pathogenesis could be related to an infection superimposed on a predisposing genetic background. However, at present, no direct evidence for an infectious implication in MS autoimmunity exists. Recently, the potential role of Chlamydia pneumoniae as a causative agent of MS has received increasing attention. After the initial high rates reported for molecular and culture demonstration of C. pneumoniae in cerebrospinal fluid (CSF) of MS patients, the association between C. pneumoniae and MS was intensively investigated with controversial results. Seroepidemiological reports did not show any strong association between C. pneumoniae infection and the risk of MS. Isolation techniques failed to detect C. pneumoniae in CSF and brain tissue of MS patients. Polymerase chain reaction (PCR) evidence of C. pneumoniae in CSF and intrathecal synthesis of anti-C. pneumoniae IgG have been undetectable in MS patients or, if present, were not selectively associated with MS, but were shared by several inflammatory neurological conditions. Nevertheless, in a subgroup of MS patients, an association between PCR positivity for C. pneumoniae in CSF and disease activity was found. Intrathecal production of anti-C. pneumoniae high-affinity IgG predominated in MS progressive forms and metabolically active C. pneumoniae was identified in CSF. C. pneumoniae was recognized in CSF and brain tissue at immunohistochemical, molecular and ultrastructural levels. C. pneumoniae was also able to induce the animal model of MS. This growing body of data does not support a central role for C. pneumoniae as a candidate in MS pathogenesis, but suggests that, in a subset of MS patients, C. pneumoniae could induce a chronic persistent brain infection acting as a cofactor in the development of the disease. Thus, the actual involvement of C. pneumoniae in MS still remains to be elucidated.

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Section: Chlamydia Pneumoniae As Putative Candidate For Msmentioning

confidence: 99%

Under the Microscope: Focus on Chlamydia pneumoniae Infection and Multiple Sclerosis

Fainardi¹,

Castellazzi²,

Seraceni³

et al. 2008

CNR

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“…Macrophages derived from circulating monocytes are localised in atherosclerotic plaques. C. pneumoniae has been detected in peripheral blood mononuclear cells [9,10] and provide a mechanism for entry of C. pneumoniae into the vessel wall [11]. In infected tissues the obligate intracellular bacterium C. pneumoniae has a unique biphasic life cycle that sometimes may be interrupted such that the bacterium passes into a non-replicative and persistent state unsusceptible to antibiotics [12].…”

Section: Introductionmentioning

confidence: 99%

Thoracic aortic aneurysm patients with Chlamydophila pneumoniae infection showed a shift in trace element levels in serum and diseased aortic tissue

Nyström-Rosander

Frisk

Edvinsson

et al. 2009

Journal of Trace Elements in Medicine and Biology

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“…Furthermore, recent evidence suggests that the organism may infect macrophages within the respiratory tract and use the blood stream for systemic dissemination (Airenne et al , 1999; Gieffers et al , 2004). It has been increasingly recognised that C. pneumoniae may be linked to some chronic inflammatory diseases, including sclerotic cardiovascular disease (Grayston et al , 2000; Bahrmand et al , 2004; Halfon et al , 2006; Kaplan et al , 2006; Romano et al , 2006; Khalili et al , 2007; Wang et al , 2007). An association with reactive arthritis (Inman et al , 2000; Villareal et al , 2002) and lung cancer (Littman et al , 2005) has been reported.…”

mentioning

confidence: 99%

Detection of Chlamydia pneumoniae in peripheral blood mononuclear cells of healthy blood donors in Tehran Regional Educational Blood Transfusion Centre

Karimi

Samiei

Hatami

et al. 2010

Transfusion Medicine

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Chlamydia pneumoniae is a common pathogen in the world often causing upper or lower respiratory tract infection and may also be linked to some chronic inflammatory diseases. Recent studies have shown that a high percentage of healthy blood donors harbour Chlamydia DNA and antigens. The objective of this study was to investigate the presence of this microorganism among blood donors. Blood samples were collected between November 2004 and March 2005 from 196 healthy blood donors. Ten millilitre of blood was collected in ethylenediaminetetraacetic (EDTA) tube. Reverse transcription of RNA was performed with Moloney murine leukaemia virus (MMLV) reverse transcriptase and random primers hexamer. Polymerase chain reaction products were evaluated by electrophoresis. Data were analysed using the chi(2) test and t-test. Of the 196 healthy blood donors, 7.1% were C. pneumoniae DNA positive (CI 95 % = 3.51- 10.69), which is slightly higher in female (8.5%) than male (6.5%) donors; this difference was not found to be significant (P = 0.4). The average age of study groups was 40.84 (SD +/- 10.80) years; significant association was not found between age groups and the presence of C. pneumoniae DNA. There was no significant differences between positive rate and first-time [37 (19.3%)] and repeat [155 (80.7%)] donors. C. pneumoniae DNA seems to be frequent in apparently healthy blood donors; therefore, it can be a threat for blood safety. But further studies are needed to evaluate the survival of C. pneumoniae in blood bank conditions and in blood recipients to define the clinical importance of such findings. Elimination of intracellular bacteria by filtration is an effective strategy for risk reduction.

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Chronic Chlamydia pneumoniae infection in patients with symptomatic atherothrombosis

Cited by 3 publications

References 26 publications

Under the Microscope: Focus on Chlamydia pneumoniae Infection and Multiple Sclerosis

Under the Microscope: Focus on Chlamydia pneumoniae Infection and Multiple Sclerosis

Thoracic aortic aneurysm patients with Chlamydophila pneumoniae infection showed a shift in trace element levels in serum and diseased aortic tissue

Detection of Chlamydia pneumoniae in peripheral blood mononuclear cells of healthy blood donors in Tehran Regional Educational Blood Transfusion Centre

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