Chronic Chikungunya Virus Disease

McCarthy, Mary K.; Davenport, Bennett; Morrison, Thomas E.

doi:10.1007/82_2018_147

Cited by 15 publications

(8 citation statements)

References 86 publications

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“…Progression to the chronic phase appears to be independent of the viral strain and location of the outbreak. Some studies have positively correlated factors such as increasing age, time of acute disease persistence, female gender, pre-existing rheumatologic conditions, high viral titers and high level of anti-CHIKV antibodies with the persistence of the disease to a chronic phase ( 78 , 79 ). High levels of interleukin 12 have been linked to both the acute and chronic phases of the disease ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Increased platelet activation and platelet-inflammasome engagement during chikungunya infection

et al. 2022

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Chikungunya fever is a viral disease transmitted by mosquitoes of the genus Aedes. The infection is usually symptomatic and most common symptoms are fever accompanied by joint pain and swelling. In most cases symptoms subside within a week. However, severe prolonged and disabling joint pain, that may persist for several months, even years, are reported. Although the pathogenesis of Chikungunya infection is not fully understood, the evolution to severe disease seems to be associated with the activation of immune mechanisms and the action of inflammatory mediators. Platelets are recognized as inflammatory cells with fundamental activities in the immune response, maintenance of vascular stability and pathogenicity of several inflammatory and infectious diseases. Although the involvement of platelets in the pathogenesis of viral diseases has gained attention in recent years, their activation in Chikungunya has not been explored. The aim of this study was to analyze platelet activation and the possible role of platelets in the amplification of the inflammatory response during Chikungunya infection. We prospectively included 132 patients attended at the Quinta D'Or hospital and 25 healthy volunteers during the 2016 epidemic in Rio de Janeiro, Brazil. We observed increased expression of CD62P on the surface of platelets, as well as increased plasma levels of CD62P and platelet-derived inflammatory mediators indicating that the Chikungunya infection leads to platelet activation. In addition, platelets from chikungunya patients exhibit increased expression of NLRP3, caspase 4, and cleaved IL-1b, suggestive of platelet-Frontiers in Immunology frontiersin.org 01

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Section: Discussionmentioning

confidence: 99%

Increased platelet activation and platelet-inflammasome engagement during chikungunya infection

et al. 2022

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“…The persistence of arboviruses in the muscle compartment is a question of major concern [107][108][109]. Indeed, clinical muscular symptoms may remain after the acute phase, e.g., in DENV infection where myalgia persisted in 60% of patients [30], as in SINV six months after infection [31].…”

Section: Possible Mechanisms Of Pathophysiology Of Arbovirus Associatmentioning

confidence: 99%

Arboviruses and Muscle Disorders: From Disease to Cell Biology

Filippone

Legros

Jeannin

et al. 2020

Viruses

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Infections due to arboviruses (arthropod-borne viruses) have dramatically increased worldwide during the last few years. In humans, symptoms associated with acute infection of most arboviruses are often described as “dengue-like syndrome”, including fever, rash, conjunctivitis, arthralgia, and muscular symptoms such as myalgia, myositis, or rhabdomyolysis. In some cases, muscular symptoms may persist over months, especially following flavivirus and alphavirus infections. However, in humans the cellular targets of infection in muscle have been rarely identified. Animal models provide insights to elucidate pathological mechanisms through studying viral tropism, viral-induced inflammation, or potential viral persistence in the muscle compartment. The tropism of arboviruses for muscle cells as well as the viral-induced cytopathic effect and cellular alterations can be confirmed in vitro using cellular models. This review describes the link between muscle alterations and arbovirus infection, and the underlying mechanisms.

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“…Acute CHIKV infection in humans may cause mild to moderate febrile disease, which is typically accompanied by rash, headache, myalgia, and intense polyarthralgia. Although most of the patients have a self-limited disease course, some individuals can progress to a chronic phase, characterized by continuous of recurring polyarthralgia that may last from months to years (7). Chronic arthralgia post-CHIKV infection also can lead to limitation of movements, incapacity for work, and even depression, directly affecting household incomes and representing a significant disease burden for affected populations (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection

et al. 2021

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The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1β, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1β, IL-12, TNF, IFN-γ, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia.

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Chronic Chikungunya Virus Disease

Cited by 15 publications

References 86 publications

Increased platelet activation and platelet-inflammasome engagement during chikungunya infection

Increased platelet activation and platelet-inflammasome engagement during chikungunya infection

Arboviruses and Muscle Disorders: From Disease to Cell Biology

Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection

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