Chronic Chagas disease with advanced cardiac complications in Japan: Case report and literature review

Imai, K.; Maeda, Takeshi; Sayama, Yusuke; Osa, Morichika; Mikita, Kei; Kurane, Ichiro; Miyahira, Yasushi; Kawana, Akihiko; Miura, Sachio

doi:10.1016/j.parint.2015.02.005

Cited by 29 publications

(25 citation statements)

References 14 publications

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“…The first case of imported T. cruzi infection was reported in Romania in 1981 [ 41 ]. Since then, an increasing number of cases has been reported in Japan, the US, and Europe, which is due to the migration of people from endemic areas [ 6 , 16 , 42 , 43 ]. The US has the largest number of Latin American immigrants, estimated at 22 million, with T. cruzi infection cases estimated at around 300,167 [ 44 ].…”

Section: What Needs To Be Done To Control and Eliminate The Transmissmentioning

confidence: 99%

Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries

Liu

Zhou

2015

Infect Dis Poverty

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American trypanosomiasis, commonly known as Chagas disease, is caused by the flagellate protozoan parasite Trypanosoma cruzi. An estimated eight million people infected with T. cruzi currently reside in the endemic regions of Latin America. However, as the disease has now been imported into many non-endemic countries outside of Latin America, it has become a global health issue. We reviewed the transmission patterns and current status of disease spread pertaining to American trypanosomiasis at the global level, as well as recent advances in research. Based on an analysis of the gaps in American trypanosomiasis control, we put forward future research priorities that must be implemented to stop the global spread of the disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-015-0092-7) contains supplementary material, which is available to authorized users.

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Section: What Needs To Be Done To Control and Eliminate The Transmissmentioning

confidence: 99%

Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries

Liu

Zhou

2015

Infect Dis Poverty

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“…CD is endemic in Latin America but is increasingly found in other parts of the world, including countries previously considered free of CD such as Japan (Imai et al, 2015), Australia, and New Zealand (Jackson et al, 2014; Pinto et al, 2014). There is an estimate of 6–7 million people currently infected with T. cruzi , and the cost of treatment for CD remains substantial.…”

Section: Introductionmentioning

confidence: 99%

Moderate Treadmill Exercise Training Improves Cardiovascular and Nitrergic Response and Resistance to Trypanosoma cruzi Infection in Mice

et al. 2017

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There is evidence suggesting that exercise training (ET) acts as a factor toward resistance to Trypanosoma cruzi infection. However, the effects of mean arterial pressure (MAP), heart rate (HR), and nitric oxide (NO) during the acute phase of infection has not been elucidated yet. Swiss mice were randomly assigned into four groups: sedentary control (SC, n = 30), trained control (TC, n = 30), sedentary infected (SI, n = 30), and trained infected (TI, n = 30). ET was performed on the treadmill for 9 weeks. After training, the mice were infected with 5 × 103 trypomastigotes of T. cruzi (Y strain) or PBS. We observed resting bradycardia and improved performance in trained animals compared with sedentary ones. On the 20th day post-infection (DPI), we found a decrease in HR in SI animals compared to TI animals (699.73 ± 42.37 vs. 742.11 ± 25.35 bpm, respectively, P < 0.05). We also observed increased production of NO in cardiac tissue on the 20th DPI in the SI group, normalized in TI group (20.73 ± 2.74 vs. 6.51 ± 1.19 μM, respectively). Plasma pro-inflammatory cytokines (IL-12, TNF-α, IFN-γ,) and MCP-1 were increased in SI animals, but decreased in TI animals. The increase in parasitemia on the 15th and 17th DPI in the SI group was attenuated in the TI group. Our results suggest that previous ET plays a preventive role in resistance to T. cruzi infection, modulating cardiovascular aspects, inflammatory reaction, and NO levels of infected mice.

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“…In Spain, only Catalonia, Valencia, and Galicia regions had protocols in screening pregnant women from Latin America up to 2014 [8]. The other countries do not have national programs for disease prevention [32,33]. The adoption of screening protocols is extremely important since the identification and treatment of infected newborns have good therapeutic results [24].…”

Section: Complexitymentioning

confidence: 99%

Congenital and Blood Transfusion Transmission of Chagas Disease: A Framework Using Mathematical Modeling

et al. 2018

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Chagas disease or American trypanosomiasis is an important health problem in Latin America. Due to the mobility of Latin American population around the world, countries without vector presence started to report disease cases. We developed a deterministic compartmental model in order to gain insights into the disease dynamics in a scenario without vector presence, considering congenital transmission and transmission by blood transfusion. The model was used to evaluate the epidemiological effect of control measures. It was applied to demographic data from Spain and sensitivity analysis was performed on model parameters associated with control strategies.

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Chronic Chagas disease with advanced cardiac complications in Japan: Case report and literature review

Cited by 29 publications

References 14 publications

Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries

Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries

Moderate Treadmill Exercise Training Improves Cardiovascular and Nitrergic Response and Resistance to Trypanosoma cruzi Infection in Mice

Congenital and Blood Transfusion Transmission of Chagas Disease: A Framework Using Mathematical Modeling

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