Chronic Catheterization of Coronary Artery: Induction of ECG Pattern of Myocardial Ischemia by Intracoronary Epinephrine.

Barger, A. C.; Herd, J. Alan; Liebowitz, Martin R.

doi:10.3181/00379727-107-26661

Cited by 32 publications

(9 citation statements)

References 1 publication

(1 reference statement)

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“…Between 75 and 180 min, ventricular ectopic beats were seen in six of eight hormone-treated animals at a frequency of 3 to 17/min, persisting for 7 to 44 min. The previously described ST-T changes after epinephrine 27 were seen in all animals. Control infusions of saline produced no significant changes in the extraction of ions or enzyme nor in the epicardial electrocardiogram.…”

Section: Regan Moschos Lehan Oldewurtel Hellemssupporting

confidence: 68%

Lipid and Carbohydrate Metabolism of Myocardium During the Biphasic Inotropic Response to Epinephrine

Regan

Moschos

Lehan

et al. 1966

Circulation Research

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The metabolic response of the left ventricle to a 90 min regional infusion of 1-epinephrine (5 /ig/min) was assessed in the intact anesthetized dog for 3 hr. The first hour was characterized by a rise in stroke output at constant filling pressure. Subsequently, contractility fell and there was release of K and PO 4 ions as well as SGOT from the myocardium that was attributed to tissue injury. The myocardial RQ rose for the first hour, presumably due to glycogenolysis, since carbohydrate extraction from blood was unaltered. Production of lactate by the myocardium during the RQ rise occurred without ischemia, since blood flow (Kr 8J method) and O 2 uptake rose 10%. The proportionately greater increase in contractility was not consistent with "O L . wasting" as a basis for the injury. After 1 hr the RQ fell to levels consistent with predominant lipid utilization. However, FFA extraction declined and the oxidation, extraction and incorporation of palmitate-l-C* into tissue lipid were diminished during hormone exhibition. Plasma triglyceride uptake, insignificant in controls, was enhanced during the 3 hr without a rise in arterial concentration. Oxidation of this lipid was insufficient to prevent a threefold triglyceride increment in the myocardium. The authors discuss a possible relationship of these metabolic alterations to the pathophysiologic response induced by epinephrine.

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Section: Regan Moschos Lehan Oldewurtel Hellemssupporting

confidence: 68%

Lipid and Carbohydrate Metabolism of Myocardium During the Biphasic Inotropic Response to Epinephrine

Regan

Moschos

Lehan

et al. 1966

Circulation Research

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“…Potentially fatal ventricular arrhythmias as a mode of presentation seem to be rare [51,65] and mainly occur during paroxysmal crisis [58,66]. In experimental animals [59,[69][70][71] and in healthy human subjects [20,72] A causes increases in heart rate (10¹20 min ¹1 ), ectopic rhythms, a decrease in T-wave voltage in 10% of the subjects and a depression of the ST segment. In experimental animals [59,[69][70][71] and in healthy human subjects [20,72] A causes increases in heart rate (10¹20 min ¹1 ), ectopic rhythms, a decrease in T-wave voltage in 10% of the subjects and a depression of the ST segment.…”

Section: Catecholamine Secretion and Ecg Abnormalitiesmentioning

confidence: 99%

Cardiological effects of catecholamine‐secreting tumours

̈Rmeyer

Engeroff

Dralle

et al. 1997

Eur J Clin Investigation

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Correlations between endocrine and cardiological findings were investigated in 106 patients with catecholamine-secreting tumours during the florid phase of their illness. Endocrine data showed an elevation of urinary catecholamine or vanillylmandelic acid excretion in all but one subject. Hypertension was found in 78%, symptoms of coronary heart disease in 26% and arrhythmias in 20% of the patients. Twelve per cent of the patients came to the hospital with heart attacks, 7% with acute left heart failure and 6% with myocardial infarction. At admission electrocardiograph (ECG) analysis showed a sinus rhythm in 98%, tachycardia > 100 min-1 in 14% and bradycardia < 60 min-1 in 10%. In 16% of the ECGs cQT was increased, in 17% the ST segment was lowered and in 37% abnormal T waves occurred. Indices of myocardial hypertrophy such as the Sokolow index, the modified Romhilt-Estes score and the Murphy score were raised in 29%, 19% and 38% respectively. In 23 of 51 (45%) patients echocardiography showed left ventricular hypertrophy, in 16% mitral valve insufficiency and in 24% disturbances of contractility. Comparison of cardiac and endocrine parameters confirm in vitro and animal studies indicating that, in particular, the alpha-mimetic noradrenaline (NA) has deleterious effects on the cardiovascular system. Urinary NA, but not adrenaline or dopamine, excretion was significantly higher in constantly hypertensive than in normotensive patients and associated with an elevation of the Sokolow index and the Romhilt-Estes score. Both indices and plasma NA were higher in patients with myocardial hypertrophy and we found a significant correlation between the Romhilt-Estes score and NA excretion.

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“…We implanted a silastic catheter in the County Heart Association, aorta to obtain aortic blood pressure and heart rate. In two dogs we implanted a modified Herd-Barger tube (6,7) in the left circumflex coronary artery distal to the occlusive cuff to administer ouabain directly into the coronary circulation.…”

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confidence: 99%