Chronic but not acute nicotine treatment ameliorates acute inflammation‐induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice
Xiaona Wang,
Qian Wang,
Min Song
et al.
Abstract:BackgroundSystemic inflammation in which lipopolysaccharide (LPS) is released into circulation can cause cognitive dysfunction and we have previously shown that LPS impaired working memory (WM) which refers to the ability to guide incoming behavior by retrieving recently acquired information. However, the mechanism is not very clear, and currently, there is no approved strategy to improve inflammation‐induced WM deficit. Notably, epidemiological studies have demonstrated a lower occurrence rate of inflammatory… Show more
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