Chronic bile diversion does not alter canine interdigestive myoelectric activity

Hughes, Steven J.; Behrns, Kevin E.; Sarr, Michael G.

doi:10.1007/bf01295721

Cited by 8 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, controversial results have been reported on the relationship of phase III and gall bladder contraction in the interdigestive state. 30 Also, in the present study, no effects of intraduodenal bile salt infusions on MMC cycle length were found (table 1). The mechanism of the negative feedback control in the fasting state deserves further comment.…”

Section: Discussioncontrasting

confidence: 46%

Intraduodenal conjugated bile salts exert negative feedback control on gall bladder emptying in the fasting state without affecting cholecystokinin release or antroduodenal motility

Ooteghem¹

2002

Gut

View full text Add to dashboard Cite

Background: Intraduodenal bile salts exert negative feedback control on postprandial gall bladder emptying. Aims: We wished to examine whether a similar control mechanism occurs in the fasting state. Methods: Intraduodenal bile salt depletion was achieved by 12 g of cholestyramine. Thereafter, in study A (seven subjects), the effects on gall bladder volume (by ultrasound) and antroduodenal motility of intraduodenal infusions of taurocholate egg yolk-phosphatidylcholine micelles were assessed. In study B (nine subjects), the effects on gall bladder volume of infusing mixed micelles composed of taurocholate (100 mM) and low (26 mM) or high (68 mM) amounts of egg yolk-phosphatidylcholine, or low amounts of dipalmitoylphosphatidylcholine were determined. Results: Cholestyramine induced strong and prolonged gall bladder contraction without cholecystokinin release. In study A, micellar infusions increased gall bladder volume without affecting migrating motor complex cycle length. In study B, intraduodenal infusion induced strong increases in gall bladder volume in the case of taurocholate micelles containing low amounts of egg yolk-phosphatidylcholine, moderate increases in micelles containing low amounts of dipalmitoylphosphatidylcholine but no change in micelles containing high amounts of egg yolk-phosphatidylcholine, in all cases without altered plasma cholecystokinin levels. Phosphatidylcholine hydrolysis was significantly higher after infusion of egg yolk-phosphatidylcholine compared with infusion of dipalmitoylphosphatidylcholine containing micelles. Intermixed micellar-vesicular bile salt concentrations (responsible for detergent effects) were higher in egg yolk-phosphatidylcholine than in dipalmitoylphosphatidylcholine containing model biles and if lyso-phosphatidylcholine was included. Conclusions: Intraduodenal bile salts exert negative feedback on fasting gall bladder volume. The modulating effects of various phospholipids may relate to their effects on intermixed micellar-vesicular bile salt concentrations.

show abstract

Section: Discussioncontrasting

confidence: 46%

Intraduodenal conjugated bile salts exert negative feedback control on gall bladder emptying in the fasting state without affecting cholecystokinin release or antroduodenal motility

Ooteghem¹

2002

Gut

View full text Add to dashboard Cite

show abstract

“…Nevertheless, controversial results have been reported on the relationship of phase III occurrence and intestinal bile salts in the interdigestive state. After biliary diversion in dogs, some investigators have reported unchanged MMC cycling, 14 whereas others reported a loss of MMCs. 13,15 In humans, two previous studies from our group found no effects of intraduodenal bile salt infusions on timing of the various phases of the MMC.…”

Section: Discussionmentioning

confidence: 99%

Effects of ileal bile salts on fasting small intestinal and gallbladder motility

Ooteghem¹,

Samsom²,

Erpecum³

et al. 2002

Neurogastroenterology Motil

View full text Add to dashboard Cite

In the fasting state, gallbladder emptying is related to phase III of the intestinal migrating motor complex. The effects of ileal infusion of mixed taurocholate-phospholipid micelles on fasting small intestinal motility (by a 17-channel catheter with side holes located in duodenum, jejunum and ileum) and gallbladder motility (by ultrasound) were investigated in eight healthy volunteers. After bile salt depletion by cholestyramine, 0.9% NaCl or mixed micelles were infused in the ileum during phase II of the migrating motor complex. Time to onset of subsequent phase III was significantly shorter after infusion of mixed micelles compared with 0.9% NaCl (32 +/- 5 min vs. 60 +/- 5 min, P = 0.01). Distal to the infusion port, numbers of pressure waves and their amplitudes were significantly lower during bile salt infusion compared with 15 min before infusion (11 +/- 6 per 15 min vs. 21 +/- 8 per 15 min, and 2.4 +/- 0.6 kPa vs. 2.8 +/- 0.5 kPa, respectively). Micellar infusions increased fasting gallbladder volumes to 170 +/- 5% of starting volumes (P < 0.0001). In conclusion, ileal infusion of mixed micelles influences the timing of phase III of the intestinal migrating motor complex, inhibits ileal motility and increases fasting gallbladder volumes. These findings may have important consequences for enterohepatic circulation of bile salts.

show abstract

“…The former studies argue that an intact enterohepatic circulation is essential for normal MMC cycling, with initiation of normal MMCs by bile acid stimulation of putative receptors existing between the portal vein and intrahepatic bile ducts. Bile should then not even be necessary in the duodenum for regulation of the MMC [13, 34]. Another role of bile may be that of an excitatory modulator that decreases the relative refractory period of the gastrointestinal MMC for other stimuli like motilin, thereby increasing the rate of MMC cycling [8].…”

Section: Discussionmentioning

confidence: 99%

“…Studies in rats and dogs showed that bile diversion disturbs the normal MMC, and subsequent intraduodenal infusion of bile acids or bile restores the MMC pattern [8, 9, 10, 11]. In contrast, some other studies report no changes in the MMC after chronic bile diversion [12, 13]. In humans, a close association between inter-digestive gallbladder motility and gastroduodenal motility is found [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Effects of Intraduodenal Bile on Interdigestive Gastrointestinal and Gallbladder Motility in Healthy Subjects

Luiking¹,

Kloppers²,

Roelofs³

et al. 2001

Digestion

View full text Add to dashboard Cite

Background/Aims: The enterohepatic circulation of bile acids is related to normal inter-digestive gastrointestinal motility, with the gut peptide motilin also being involved. This study aimed to investigate the effect of intraduodenal artificial bile infusion on antroduodenal and gallbladder motility so as to further elucidate the controlling factors. Methods: Twelve fasting, healthy male volunteers received artificial bile (80 mol% bile acids; 15 mol% phospholipids; 5 mol% cholesterol) or placebo (saline) intraduodenally for 10 min starting 30 min after the end of phase III, according to a double-blind, randomised, cross-over design. Antroduodenal motility, gallbladder volumes, and plasma motilin levels were measured. All values are means ± SEM. Results: The interval between infusion and the subsequent phase III, as well as the origin of this phase III were not significantly different between bile and saline. Antral pressure waves were significantly more frequent during and immediately after bile infusion compared with saline infusion (p < 0.05). The duration of phase I following infusion was significantly longer after bile (24.8 ± 3.7 min) than after saline infusion (13.1 ± 1.7 min; p < 0.05). The mean gallbladder volume tended to increase in the hours following bile infusion, but to decrease after saline infusion (p = 0.06). Plasma motilin increased after bile and saline infusion in an almost identical way. Conclusion: This study provides no clear evidence for a role of intraduodenal artificial bile (i.e. its main constituents) in the regulation of migrating motor complex cycling or feedback inhibition of inter-digestive gallbladder emptying.

show abstract

Chronic bile diversion does not alter canine interdigestive myoelectric activity

Cited by 8 publications

References 27 publications

Intraduodenal conjugated bile salts exert negative feedback control on gall bladder emptying in the fasting state without affecting cholecystokinin release or antroduodenal motility

Intraduodenal conjugated bile salts exert negative feedback control on gall bladder emptying in the fasting state without affecting cholecystokinin release or antroduodenal motility

Effects of ileal bile salts on fasting small intestinal and gallbladder motility

Effects of Intraduodenal Bile on Interdigestive Gastrointestinal and Gallbladder Motility in Healthy Subjects

Contact Info

Product

Resources

About