Chronic autoimmune thyroid disease in children and adolescents in the years 1999-2004 in Lower Silesia, Poland

Abstract

The aim of the study was to analyze data related to chronic autoimmune thyroid disease at diagnosis and at follow-up of children and adolescents in Lower Silesia in the years 1999-2004. Age, gender, incidence of thyroid disease in the family, clinical presentation, hormonal findings, levels of thyroid antibodies, results of ultrasonography, and fine needle aspiration biopsy (FNAB) were recorded. 100 children, 10 boys and 90 girls, were included in the analysis. The mean age at diagnosis was 12.3±2.3 years and at last examination 14.9±1.9 years. At diagnosis, increased levels of TSH without overt hypothyroidism was observed in 26 children. In 11 children hyperthyroidism was detected whereas 63 children were euthyroid. An increased level of thyroid peroxidase antibodies was observed in 65% of the children. Ultrasonography was characteristic for Hashimotos thyroiditis in all patients. Fine needle biopsy was performed when there were diagnostic difficulties (35% children). Thus, in all the children the diagnosis of Hashimotos thyroiditis was ascertained either by high antibody titer or FNAB. Associated diseases were observed in 33% of the children. Thyroid disease in the family was present in 25% of the children. There was a gradual decline in the number of new cases presented from 1999 to 2004. The reason for this decline remains speculative.

Possible Roles of Micro RNA‑142‑5p and Claudin-1 in Development of Hashimoto’s Thyroiditis in Iraqi Patients

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A rare case of coexistence of autoimmune polyglandular syndrome type 3 with growth hormone deficiency and hyperthyroidism in a patient with pseudo-Turner’s syndrome

“…The age of onset of APS-1 is low, it usually fully manifests before the age of 20, and it is related to a mutation in the AIRE (Autoimmune Regulator) gene on chromosome 21. 6 APS-2 (Schmidt's disease) comprises Addison's disease, along with autoimmune thyroid disease and/or type 1 diabetes mellitus. It can develop at any age and in both sexes, but it is most frequently diagnosed in middle-aged women, and rarely in childhood.…”

Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children

“…Thyroid function at HT presentation may significantly vary in the different pediatric cohorts [8, 9, 21–23]. In children euthyroidism is the most frequent presenting pattern, followed by SH and overt hypothyroidism [24].…”