Chronic autoimmune thrombocytopenic purpura

Fotos, Pete G.; Graham, William L.; Bowers, Dale C.; Perfetto, Stephen P.

doi:10.1016/0030-4220(83)90371-7

Cited by 2 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In severe cases of ITP, oral hematomas and hemorrhagic bullae may be the presenting clinical sign. 37,38 Most patients with chronic ITP are young women. Intracerebral hemorrhage, although rare, is the most common cause of death.…”

Section: Acquired Platelet Disordersmentioning

confidence: 99%

“…Corticosteroids are indicated for ITP, with titration governed by the severity of hemorrhagic symptoms. 37,38 Splenectomy may be necessary in chronic ITP to prevent antiplatelet antibody production and sequestration and removal of antibody-labeled platelets. 38 Plasma exchange therapy combined with aspirin/dipyridamole or corticosteroids has recently lowered the mortality rate for patients with TTP over that previously obtained by treatment with fresh frozen plasma (FFP) infusions.…”

Section: Platelet Disordersmentioning

confidence: 99%

“…37,38 Splenectomy may be necessary in chronic ITP to prevent antiplatelet antibody production and sequestration and removal of antibody-labeled platelets. 38 Plasma exchange therapy combined with aspirin/dipyridamole or corticosteroids has recently lowered the mortality rate for patients with TTP over that previously obtained by treatment with fresh frozen plasma (FFP) infusions. 67,68 The thrombocytopenia of Wiskott-Aldrich syndrome may be managed with platelet transfusions, splenectomy, or bone marrow transplantation.…”

Section: Platelet Disordersmentioning

confidence: 99%

See 2 more Smart Citations

Bleeding and Clotting Disorders

Napeñas¹,

Patton²

2021

Burket's Oral Medicine

View full text Add to dashboard Cite

Dental health care workers are increasingly called upon to provide quality dental care to individuals whose bleeding and clotting mechanisms have been altered by inherited or acquired diseases. This provides an opportunity for the dentist who is trained in the recognition of oral and systemic signs of altered hemostasis to assist in the diagnosis of the underlying condition. A number of dental procedures result in the risk of bleeding that can have serious consequences, such as severe hemorrhage or possibly death, for the patient with a bleeding disorder. Safe dental care may require consultation with the patient's physician, systemic management, and dental treatment modifications.Of the inherited coagulopathies, von Willebrand's disease (vWD) is the most common. It results from deficiency of von Willebrand's factor (vWF) and affects about 0.8 to 1% of the population. 1 Hemophilia A, caused by coagulation factor (F) VIII deficiency, is the next most common, followed by hemophilia B, a F IX deficiency. The age-adjusted prevalence of hemophilia in six surveillance states in 1994 was 13.4 cases in 100,000 males (10.5 for hemophilia A and 2.9 for hemophilia B). 2 Application to the US population resulted in an estimated national prevalence of 13,320 cases of hemophilia A and 3,640 cases of hemophilia B, with an incidence rate of 1 per 5,032 live male births. Hemophilia A was predominant, accounting for 79% of all hemophiliacs, and prevalence of disease severity was 43% severe (< 1% F VIII), 26% moderate (1-5% F VIII), and 31% with mild (6-30% F VIII) disease. 2 Acquired coagulation disorders can result from drug actions or side effects, or underlying systemic disease. A stratified household sample of 4,163 community residents aged 65 years or older living in a five-county area of North Carolina revealed 51.7% to be taking one or more medications (aspirin, warfarin, dipyridamole, nonsteroidal anti-inflammatory drugs

show abstract

Section: Acquired Platelet Disordersmentioning

confidence: 99%

Section: Platelet Disordersmentioning

confidence: 99%

Section: Platelet Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Bleeding and Clotting Disorders

Napeñas¹,

Patton²

2021

Burket's Oral Medicine

View full text Add to dashboard Cite

show abstract

Hepatitis C infection

Kanno¹,

Castro²,

Crivelini³

2016

J Oral Diag

View full text Add to dashboard Cite

Hepatitis C is associated with autoimmune diseases, hepatocellular carcinoma, and extrahepatic manifestations that, in conjunction, may seriously compromise the patient’s quality of life. We herein describe a case of chronic hepatitis C with oral manifestations and discuss some implications for diagnosis and treatment. A 63-year-old woman complaining of spontaneous bleeding of the oral mucosa presented with bilateral asymmetric ulcers surrounded by white papules and striae on the buccal mucosa. Her medical history revealed leucopenia, thrombocytopenia, and skin lesions associated with chronic hepatitis C. Propranolol and ranitidine had recently been prescribed. Lichen planus, lichenoid reaction, and erythema multiforme were considered in the differential diagnosis. Histopathological analysis revealed lymphocytic infiltrate in a lichenoid pattern. The lesions partially healed after 1 week and completely regressed after 6 months, despite the maintenance of all medicaions; no recurrence was observed. The final diagnosis was oral lichen planus associated with hepatitis C. Chronic hepatitis C may present oral manifestations, which demand adjustments in dental treatment planning. Medication side effects may interfere with the clinical presentation and course of the disease and should be accounted for in the differential diagnosis. The possibility of spontaneous remission of oral lichen planus should always be considered, especially when putative etiological factors of a lichenoid lesion are withdrawn in an attempt to differentiate oral lichen planus from lichenoid lesions. This case emphasizes the importance of recognizing the extrahepatic manifestations of hepatitis C as a cause of increased morbidity.

show abstract

Chronic autoimmune thrombocytopenic purpura

Cited by 2 publications

References 12 publications

Bleeding and Clotting Disorders

Bleeding and Clotting Disorders

Hepatitis C infection

Contact Info

Product

Resources

About