Chronic atrophic oral candidiasis among patients with diabetes mellitus – role of secretor status

Abstract

SUMMARYNon-diabetic individuals who are non-secretors of blood group antigens are prone to superficial infections by Candida albicans. In this study, 216 patients with diabetes mellitus who were denture wearers were examined for the presence or absence of denture stomatitis. There was an overall trend for non-secretors to be prone to denture stomatitis compared with secretors. Stepwise linear discriminant analysis was used to dissect the contribution of secretor status and other variables to the development of the disease. Secretor status was found to be a contributory factor among patients with non-insulin dependent diabetes but not among those with insulin-dependent diabetes. The possible reasons for this are discussed.

Factors influencing oral carriage of yeasts among individuals with diabetes mellitus

“…These results are similar to studies which found 60 % of isolates from diabetics to be C. albicans [3,16]. This emphasizes the need for accurate identification as patients with diabetes are more likely to carry and to have disease due to species other than C. albicans [18] which might not be sensitive to routinely prescribed oral antifungal agents [19]. The third objective was to assess the association between secretor status and carriage of yeasts among individuals with IDDM separately from those with NIDDM.…”

Species distribution and influence of glycemic control on fungal infections in pregnant women with diabetes

“…In addition, C. glabrata and C. tropicalis were isolated mainly from diabetic patients carriers of dentures. 1,7 In our study, we found in mouthwash from DM, GDM, CON, both higher prevalence of C. albicans (77.3%, 79.3%, 70.0%, respectively) and C. glabrata (13.6%, 6.9%, 10.9%, respectively). These data are supported by another Polish study where in oral cavity of non-diabetics C. glabrata was found in 20 -66%.…”

“…Accurate identification of strains isolated from diabetic patients is especially important because they are more likely to carry species other than C. albicans which might not be sensitive to certain antifungal agents. 1,7 Recently, Goswami et al reported that C. glabrata (39%) was a predominant species isolated from vagina of diabetic Indian women and C. albicans was detected only in 26%. Surprisingly, in healthy women C. glabrata was as frequent as C. albicans (30%).…”

“…1,5,7 Usually in these patients, the most common fungal invasions are those of genital organs, oral cavity, skin and nails. However, the reason for the high susceptibility in diabetic patients is not enough explained.…”

“…From the other side, poor glycemic control (HbA1 and plasma glucose) was a significant factor of palatal carriage of yeasts in these patients. 1,7 Since mycoses rate seems to be associated with temporary glucose levels rather than with HbA1, Goswani et al provide contradictory data. 2 The mean HbA1 in diabetic women with vulvovaginal candidosis was significantly higher than in patients without infection (12.8^2.6%, 9.7^1.7%, respectively) but as in our study, no difference was found between diabetes type 1 and 2.…”