Chronic asthma results in cognitive dysfunction in immature mice

Guo, Ruo-Bing; Sun, Peili; Zhao, Andi; Gu, Jun; Ding, Xu; Qi, Jun; Sun, Xiu‐Lan; Hu, Gang

doi:10.1016/j.expneurol.2013.04.008

Cited by 49 publications

(30 citation statements)

References 39 publications

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“…In keeping with this, it has been demonstrated that hypertension can lead to the memory loss as well as impair learning [147,149] and cognition [150]. Interestingly, in Guo et al [151], it was shown that chronic asthma can affect cognitive functions and impact synaptic transduction [152] and neurogenesis [153,154]. It has also been discussed that psycho-social stress and psychological factors can play an important role in bronchial asthma [155,156].…”

Section: Apoptosis In Asthma/hypertension Gene Networkmentioning

confidence: 86%

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

et al. 2018

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Background: Hypertension and bronchial asthma are a major issue for people's health. As of 2014, approximately one billion adults, or~22% of the world population, have had hypertension. As of 2011, 235-330 million people globally have been affected by asthma and approximately 250,000-345,000 people have died each year from the disease. The development of the effective treatment therapies against these diseases is complicated by their comorbidity features. This is often a major problem in diagnosis and their treatment. Hence, in this study the bioinformatical methodology for the analysis of the comorbidity of these two diseases have been developed. As such, the search for candidate genes related to the comorbid conditions of asthma and hypertension can help in elucidating the molecular mechanisms underlying the comorbid condition of these two diseases, and can also be useful for genotyping and identifying new drug targets. Results: Using ANDSystem, the reconstruction and analysis of gene networks associated with asthma and hypertension was carried out. The gene network of asthma included 755 genes/proteins and 62,603 interactions, while the gene network of hypertension -713 genes/proteins and 45,479 interactions. Two hundred and five genes/proteins and 9638 interactions were shared between asthma and hypertension. An approach for ranking genes implicated in the comorbid condition of two diseases was proposed. The approach is based on nine criteria for ranking genes by their importance, including standard methods of gene prioritization (Endeavor, ToppGene) as well as original criteria that take into account the characteristics of an associative gene network and the presence of known polymorphisms in the analysed genes. According to the proposed approach, the genes IL10, TLR4, and CAT had the highest priority in the development of comorbidity of these two diseases. Additionally, it was revealed that the list of top genes is enriched with apoptotic genes and genes involved in biological processes related to the functioning of central nervous system.

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Section: Apoptosis In Asthma/hypertension Gene Networkmentioning

confidence: 86%

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

et al. 2018

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“…An MRI study of 17 people on long-term steroids suggests a possible reduction in hippocampal volume and declarative memory compared with controls [ 18 ]. In an ovalbumin-induced mouse model of asthma, there was evidence of impaired learning and hippocampal damage [ 81 ]. Finally, a recent MRI study of 19 to 47 year olds with mild to moderate asthma showed that incidental brain abnormalities were common (62%), of which 25% were white matter hyperintensities [ 82 ].…”

Section: Brain Pathology and Lung Diseasementioning

confidence: 99%

Lung disease as a determinant of cognitive decline and dementia

2015

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Almost 40 million people currently live with dementia but this is estimated to double over the next 20 years; despite this, research identifying modifiable risk factors is scarce. There is increasing evidence that cognitive impairment is more frequent in those with chronic lung disease than those without. Chronic obstructive pulmonary disease affects 210 million people, with cognitive impairment present in 60% of certain populations. Co-morbid cognitive dysfunction also appears to impact on important outcomes such as quality of life, hospitalisation and survival. This review summarises the evidence of an association between cognition, impaired lung function and obstructive lung disease. It goes on to examine the contribution of neuro-imaging to our understanding of the underlying pathophysiology. While the mechanisms of brain pathology and cognitive impairment are likely to be complex and multi-factorial, there is evidence to suggest a key role for occult cerebrovascular damage independent of traditional vascular risk factors, including smoking.Electronic supplementary materialThe online version of this article (doi:10.1186/s13195-015-0116-3) contains supplementary material, which is available to authorized users.

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“…Furthermore, increased apoptosis of peripheral blood mononuclear cells was observed in patients with allergic asthma [ 9 , 10 ]. More importantly, it has been demonstrated that chronic asthma-induced hypoxia may result in systemic injuries such as cognitive dysfunction [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Activation of Bcl-2-Caspase-9 Apoptosis Pathway in the Testis of Asthmatic Mice

Guo

et al. 2016

PLoS ONE

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BackgroundApoptosis plays a critical role in controlling the proliferation and differentiation of germ cells during spermatogenesis. Dysregulation of the fine-tuned balance may lead to the onset of testicular diseases. In this study, we investigated the activation status of apoptosis pathways in the testicular tissues under the background of an asthmatic mouse model.MethodsTen BALB/c mice were divided into two groups: the acute asthma group and the control group. In the acute asthma group, ovalbumin (OVA)-sensitized mice were challenged with aerosolized OVA for 7 days, while the control group was treated with physiological saline. After that, both epididymis and testis were collected to determine the sperm count and motility. Apoptosis in the testis was evaluated by DNA ladder, immunochemistry and further by PCR array of apoptosis-related genes. Finally, the cleavage of caspase-3 and poly ADP-ribose polymerase (PARP) was determined by western blot and the enzymatic activities of caspase-9 and 3/7 were assessed using Caspase-Glo kits.ResultsCompared with control mice, significant decreases in the body weight, testis weight, sperm count and motility were seen in the experimental group. DNA ladder and immunochemistry showed significant increase in apoptotic index of the asthmatic testis, whereas a decrease in mRNA expression of Bcl-2 and increases in Bax, BNIP3, caspase-9, and AIF were observed in the asthma group. Furthermore, protein levels of AIF were significantly upregulated, while the translational expression of Bcl-2 was downregulated markedly. Consistently, caspase-9 activity in the testis of asthma mice was significantly higher than that of the control group.ConclusionCollectively, these results showed that Bcl-2-caspase-9 apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related genes and proteins. To our knowledge, this is the first report demonstrating that asthma could lead to the activation of the mitochondrial apoptosis signaling pathway in the mouse testis.

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Chronic asthma results in cognitive dysfunction in immature mice

Cited by 49 publications

References 39 publications

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

Lung disease as a determinant of cognitive decline and dementia

Activation of Bcl-2-Caspase-9 Apoptosis Pathway in the Testis of Asthmatic Mice

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