Chronic asthenia in patients who have undergone endocrine neck surgery

Scerrino, Grégorio; Brutto, Daniela Lo; Mazzola, S; Corigliano, Alessandro; Vitale, Irene; Tutino, Roberta; Rotolo, G; Orlando, G.; Cocorullo, Gianfranco

doi:10.1007/s12020-021-02838-3

Cited by 4 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be due to the limited sample size, however it is undeniable that some of those factors, including failure in maintaining the same physical activity levels as before surgery, increased intake of comfort food as sweeten beverages and, last but not least, quitting smoking, might contribute to the thyroidectomyrelated increase in body weight. Several studies reported increased complain for post-surgery asthenia in patients performing thyroidectomy [17][18][19][20]. This appears not of negligible relevance, in that, it could, at least in part, explain the here reported trend towards a reduction in physical activity in these patients [21].…”

Section: Discussionmentioning

confidence: 48%

Pre-surgery dietician counseling can prevent post-thyroidectomy body weight gain: results of an intervention trial

et al. 2023

View full text Add to dashboard Cite

Purpose It is widely accepted that patients experience weight gain after total thyroidectomy, and preventive measures should be recommended. Methods A prospective study was designed to assess the efficacy of a dietetic intervention to prevent post-thyroidectomy weight gain in patients undergoing surgery for both benign and malignant thyroid conditions. Patients undergoing total thyroidectomy were prospectively and randomly assigned to receive a personalized pre-surgery diet counseling (GROUP A) or no intervention (GROUP B), according to a 1:2 ratio. All patients underwent follow-up with body-weight measurement, thyroid function evaluation and lifestyle and eating habits assessment at baseline (T0), 45 days (T1) and 12 months (T2) post-surgery. Results The final study group encompassed 30 patients in Group A and 58 patients in Group B. The two groups were similar in terms of age, sex, pre-surgery BMI, thyroid function and underlying thyroid condition. The evaluation of body weight variations showed that patients in Group A did not experience significant body weight changes at either T1 (p = 0.127) nor T2 (p = 0.890). At difference, patients in Group B underwent a significant body weight increase from T0 to both T1 (p = 0.009) and T2 (p = 0.009). TSH levels were similar in the two groups, both at T1 and T2. Lifestyle and eating habits questionnaires failed to register any significant difference between the two groups, apart from an increase in sweetened beverages consumption in Group B. Conclusions A dietician counseling is effective in preventing the post-thyroidectomy weight gain. Further studies in larger series of patients with a longer follow-up appear worthwhile.

show abstract

Section: Discussionmentioning

confidence: 48%

Pre-surgery dietician counseling can prevent post-thyroidectomy body weight gain: results of an intervention trial

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Some studies did not apply classical QoL questionnaires, but monitored nonspecific symptoms, such as chronic fatigue or asthenia. These symptoms, despite being rather challenging to be quantified, represent an important non-specific clinical attribute of PHP and of PHP-related QoL [7,10]. For example, one study by Boone et al [39] from 2017 showed on 20,091 consecutive patients with PHP that approximately 72% of them had chronic fatigue regardless the serum calcium levels [39].…”

Section: Limits Of Addressing Qol In Subjects With Primary Hyperparat...mentioning

confidence: 99%

“…As a whole, they fall into one of the categories: neuropsychiatric/psychological, cardiovascular, articular, and muscular symptoms, and may be mistaken by patients as pertaining to the physiological aging process or to the daily stressful activities. This perception can be supplementarily enhanced by their progressive onset, which makes many patients not fully aware of them [6,8,10]. Their improvement was reported very early after PTx in some patients, yet the level of statistical evidence does not qualify these non-classical elements, including impairment of quality of life (QoL), as recommendations for PTx, this being the reason for not including them in current guidelines [6,8,11].…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine Parathyroid Tumors: Quality of Life in Patients with Primary Hyperparathyroidism

et al. 2023

View full text Add to dashboard Cite

Tumors of the parathyroid glands, when associated with PTH (parathyroid hormone) excess, display a large area of complications; in addition to the classical clinical picture of primary hyperparathyroidism (PHP), a complex panel of other symptoms/signs can be identified, including memory and cognitive impairment, chronic asthenia/fatigue, reduced muscle functionality, depressive mood, non-specific bone pain, and loss of sleep quality. The perception of quality of life (QoL) can be supplementarily enhanced by their progressive onset, which makes many patients not be fully aware of them. Their improvement was reported very early after parathyroidectomy (PTx), yet the level of statistical evidence does not qualify these non-classical elements as standalone indications for PTx. Our objective is introducing an up-to-date on QoL scores with regards to the patients diagnosed with PHP, particularly taking into consideration PHP management from baseline to post-operatory outcome, including in cases with multiple endocrine neoplasia. This is a narrative review of literature. We revised full-length papers published in English through PubMed research conducted between January 2018 and May 2023 by using the key words “quality of life” and “primary hyperparathyroidism”. We particularly looked at data on self-reported QoL (through questionnaires). We excluded from the search the studies focused on non-PTH related hypercalcemia, secondary, and/or renal/tertiary hyperparathyroidism, and vitamin D supplementation. Overall, we identified 76 papers and selected for the final analysis 16 original studies on QoL and PHP (a total of 1327 subjects diagnosed with syndromic and non-syndromic PHP). The studies with the largest number of individuals were of 92, 104, 110, 134, 159, as well as 191. A few cohorts (n = 5) were of small size (between 20 and 40 patients in each of them). Concerning the study design, except for 2 papers, all the mentioned studies provided longitudinal information, particularly the timeframe from baseline (before PTx) and after surgery. The post-operatory follow-up was of 3–6 months, but mostly between 1 and 3 years (maximum a decade of surveillance). The age of the patients varies between medians of 56, 62, 64, and 68 years. Most frequent questionnaires were SF-36, PHPQoL, and PAS. Despite not being unanimously similar, an overall reduced score of QoL in patients with PHP versus controls was registered, as well as general improvement following PTx. Variations of QoL results might have a multifactorial background from different comorbidities, studied populations, technical aspects of collecting the data, etc. QoL scores in PHP represents a complex heterogeneous picture, from their correlation with clinical features and lab assays (e.g., the level of serum calcium), the associated comorbidities (such as multiple endocrine neoplasia syndromes), up to the assessment of the QoL improvement after parathyroidectomy (PTx). While current studies do not unanimously agree on each QoL domain, the assessment of QoL might represent a supplementary argument to consider when deciding for PTx, especially in asymptomatic cases and in patients who do not fit into well-known categories of surgery candidates, according to current guidelines, thus assessing QoL in PHP is part of a current research gap. QoL evaluation in PHP remains an open issue, towards which awareness should be cultivated by both endocrinologists and surgeons. The introduction of a routine evaluation of the QoL scores in patients, as well as the selection of the most appropriate questionnaire(s), represents an open chapter thus awareness in mandatory.

show abstract

The Impact of Thyroidectomy on Sexual Function

黄

2024

ACM

View full text Add to dashboard Cite

Chronic asthenia in patients who have undergone endocrine neck surgery

Cited by 4 publications

References 49 publications

Pre-surgery dietician counseling can prevent post-thyroidectomy body weight gain: results of an intervention trial

Pre-surgery dietician counseling can prevent post-thyroidectomy body weight gain: results of an intervention trial

Neuroendocrine Parathyroid Tumors: Quality of Life in Patients with Primary Hyperparathyroidism

The Impact of Thyroidectomy on Sexual Function

Contact Info

Product

Resources

About