Chronic arthritis produced by streptococcal L‐forms

Cook, Josephine; Fincham, W J; Lack, C. H.

doi:10.1002/path.1710990404

Cited by 18 publications

(6 citation statements)

References 13 publications

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“…It was suggested that release of lysozymes within the joint tissues as a result of SLS activity may result in damage to the tissues. Similar lesions to those produced by SLS have also been produced in rabbits using streptococcal L-forms (Cook et al 1969).…”

Section: References Cotchin E and Haywardsupporting

confidence: 55%

Animal Models of Human Diseases

Drew

1972

Proceedings of the Royal Society of Medicine

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Section: References Cotchin E and Haywardsupporting

confidence: 55%

Animal Models of Human Diseases

Drew

1972

Proceedings of the Royal Society of Medicine

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“…It has been reported that viable or heatkilled streptococcal L-forms induced a chronic monarticular arthritis after intra-articular injection (6). However the same authors indicated that a wide range of materials, especially particulate matter, can induce similar arthritic changes.…”

Section: Discussionmentioning

confidence: 99%

Pathogenicity of stable L‐phase variants of staphylococcus aureus reaction of rabbit synovium to intraarticular inoculation

Linnemann

Watanakunakorn

Bakie

1974

Arthritis & Rheumatism

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Stable L-phase variants of Staphylococcus aureus were injected into the knee joints of rabbits. The recovery of organisms at various intervals was attempted and the reaction of the synovium studied. Although what appeared to be L-phase variants could be seen within polymorphonuclear leukocytes in the synovial fluid at 48 hours, they did not grow in culture. At 1 week, there was a mild synovitis characterized by both acute and chronic inflammatory changes which was diminished at 2 weeks and resolved by 5 weeks. Joints injected with L-phase variants and sterile media differed only in the degree of change. Following multiple injections a more diffuse chronic synovitis was present, and in l experimental animal rheumatoid-like changes were seen. L-phase variants could not be recovered from cultures of the synovial fluid or the synovial tissue.T h e role of wall-defective microbial variants (1) in the initiation and/or persistence of infection has not been defined. We have previously shown that a strain of L-phase wriant of Staphylococcus aureus inoculated into an in situ polyethylene catheter in the right side of the rabbit heart failed to colonize endocardia1 vegetations (2). A pathogenic role for wall-defective microbial variants in arthritis has been suggested, but the evidence is unconvincing. Pease (3) isolated an L-form of a bac-

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“…Moreover, the intra-articular presence of dead bacteria can cause an arthritis, e.g. dead streptococcal L forms (Cook, Fincham, and Lack, 1969), cell free extracts of Erysipelothrix insidiosa (White and Puls, 1969), and as little as 01 ,ug dead tubercle bacilli in FIA (A. Doble and L. E. Glynn, unpublished observations). Finally, macrophages carrying fluoresceinated group A streptococci pass to joints made arthritic by injection ofstreptolysin S (Ginsburg and Trost, 1971).…”

Section: Discussionmentioning

confidence: 99%