Chronic arthritis before 1876: early British cases suggesting rheumatoid arthritis.

Storey, Geoffrey O; Comer, M.; Scott, D L

doi:10.1136/ard.53.9.557

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…Erosive arthritis resembling RA has been described in skeletons from North America dating back as far as 6,500 years ago, and in paintings RA-like features could be seen from the 15th century onwards (395). Although its name was introduced in the 1850s by Dr Augustin Jacob Landré-Beauvais (338), the first classification criteria were developed only 50 years ago (287). In industrialized countries, RA is the most common autoimmune inflammatory arthritis which affects 0.5-1.0% of adults, with 5-50 new cases annually per 100 000 adults, diagnosis based on the 1987 revised American College of Rheumatology (ACR) criteria (5).…”

Section: General Introductionmentioning

confidence: 99%

Carotid Atherosclerosis, Disease Measures, Oxidized Low-density Lipoproteins, and Atheroprotective Natural Antibodies for Cardiovascular Disease in Early Rheumatoid Arthritis — An Inception Cohort Study

Ajeganova¹,

Fairé²,

Jogestrand³

et al. 2012

J Rheumatol

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Section: General Introductionmentioning

confidence: 99%

Carotid Atherosclerosis, Disease Measures, Oxidized Low-density Lipoproteins, and Atheroprotective Natural Antibodies for Cardiovascular Disease in Early Rheumatoid Arthritis — An Inception Cohort Study

Ajeganova¹,

Fairé²,

Jogestrand³

et al. 2012

J Rheumatol

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“…Its name was introduced in the 1850s. First classification criteria were developed only 50 years ago (Storey et al , 1994 ; Ropes et al , 1959; Arnett et al , 1988 ). Several clinical studies as well as preclinical animal models of RA have documented an imbalance in the body redox homeostasis to a more pro-oxidative environment, suggesting that therapies that restore the balance have a beneficial effect (Kunsch et al , 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological influence on processes of adjuvant arthritis: effect of the combination of an antioxidant active substance with methotrexate

Dráfi¹,

Bauerová²,

Kuncírová³

et al. 2012

Interdisciplinary Toxicology

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Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. A certain correlation was observed between oxidative stress, arthritis and the immune system. Reactive oxygen species produced in the course of cellular oxidative phosphorylation and by activated phagocytic cells during oxidative burst, exceed the physiological buffering capacity and result in oxidative stress. The excessive production of ROS can damage protein, lipids, nucleic acids, and matrix components. Patients with rheumatoid arthritis have an altered antioxidant defense capacity barrier. In the present study the effect of substances with antioxidative properties, i.e. pinosylvin and carnosine, was determined in monotherapy for the treatment of adjuvant arthritis (AA). Moreover carnosine was evaluated in combination therapy with methotrexate. Rats with AA were administered first pinosylvin (30 mg/kg body mass daily per os), second carnosine (150 mg/kg body mass daily per os) in monotherapy for a period of 28 days. Further, rats with AA were administered methotrexate (0.3 mg/kg body mass 2-times weekly per os), and a combination of methotrexate+carnosine, with the carnosine dose being the same as in the previous experiment. Parameters, i.e. changes in hind paw volume and arthritic score were determined in rats as indicators of destructive arthritis-associated clinical changes. Plasmatic levels of TBARS and lag time of Fe2+-induced lipid peroxidation (tau-FeLP) in plasma and brain were specified as markers of oxidation. Plasmatic level of CRP and activity of γ-glutamyltransferase (GGT) in spleen and joint were used as inflammation markers. In comparison to pinosylvin, administration of carnosine monotherapy led to a significant decrease in the majority of the parameters studied. In the combination treatment with methotrexate+carnosine most parameters monitored were improved more remarkably than by methotrexate alone. Carnosine can increase the disease-modifying effect of methotrexate treatment in rat AA.

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“…Such effects cannot be applied to antiinflammatory drugs and analgesics. The treatment for RA is conventionally initiated with nonsteroidal antiinflammatory drugs (NSAIDS) and continued with DMARDs and biological agents [2][3][4]. Although pharmacological agents such as NSAIDs and corticosteroid preparations are used in the current treatment of IA, they fail to provide satisfactory treatment [5].…”

Section: Reumatologia 2020; 58/5mentioning

confidence: 99%

Investigation of anti-inflammatory effects of bee venom in experimentally induced adjuvant arthritis

2020

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IntroductionRheumatoid arthritis is a multisystemic inflammatory disease characterized by destruction of the joints. An effective treatment method of the disease has not been developed yet. The aim of the present study is to evaluate the effects of bee (Apis mellifera anatoliaca) venom (BV) on serum inflammatory parameters, serum antioxidant load and clinical parameters of experimentally induced adjuvant arthritis in rats.Material and methodsA total of 35 Wistar albino male rats were used. The animals were divided into 5 groups. First group animals served as negative controls. The second, third, fourth and fifth groups were used for experimental arthritis induction. Following clinical development of arthritis, the first group was subcutaneously administered 0.2 ml of physiological saline, and the second, third and fourth groups were treated subcutaneously with 2 µg/kg, 4 µg/kg and 20 µg/kg once a week three times. Physiological saline injected fifth group animals were used as a sham-treatment group. Clinical observations and evaluation of arthritis were made at the 15th day, and at the end of the experiment. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, paraoxonase, serum aryl esterase, high-sensitivity C reactive protein, interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-) were determined in cardiac blood samples taken at the end of the 29th day.ResultsFrom the data, total oxidant level (TOL) and oxidative stress index (OSI) were calculated. Significant improvements were observed in the clinical signs of arthritis and inflammatory markers such as in IL-1, TNF-, IL-6 and TOL and OSI in the 20.0 µg/kg BV-administered group. Bee venom administration did not cause any significant increase in ALT and AST values or signs of liver toxicity.ConclusionsBee venom treatment was effective in alleviation of symptoms of the experimental rat adjuvant arthritis by means of clinical observation and serum inflammatory markers.

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Chronic arthritis before 1876: early British cases suggesting rheumatoid arthritis.

Cited by 15 publications

References 6 publications

Carotid Atherosclerosis, Disease Measures, Oxidized Low-density Lipoproteins, and Atheroprotective Natural Antibodies for Cardiovascular Disease in Early Rheumatoid Arthritis — An Inception Cohort Study

Carotid Atherosclerosis, Disease Measures, Oxidized Low-density Lipoproteins, and Atheroprotective Natural Antibodies for Cardiovascular Disease in Early Rheumatoid Arthritis — An Inception Cohort Study

Pharmacological influence on processes of adjuvant arthritis: effect of the combination of an antioxidant active substance with methotrexate

Investigation of anti-inflammatory effects of bee venom in experimentally induced adjuvant arthritis

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