Chronic arsenicism and cancer in Inner Mongolia — consequences of well-water arsenic levels greater than 50 μg/l

Luo, Zhendong; Zhang, Y. M.; Ma, Li; Zhang, G. Y.; He, Xiaodong; Wilson, Richard; Byrd, Daniel M.; Griffiths, J. Gwyn; Lai, Shenghan; Li-zhong, HE; Grumski, Karen S.; Lamm, Steven H.

doi:10.1007/978-94-011-5864-0_5

Cited by 43 publications

(30 citation statements)

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“…In the combined area of West Bengal and Bangladesh about 150 million people are at risk from arsenic contaminated ground water (21). Arsenic contamination of well water in Minnetosa and Taiwan has caused signs and symptoms of arsenic toxicity (22,23). Similar resvlts have been reported from Northern Mexico, Nova Scotia Canada, Finland, Alaska and China (24)(25)(26)(27)(28).…”

Section: Indian Journal Of Clinical Biochemistry 2004mentioning

confidence: 77%

Study on arsenic level in ground water of Delhi using hydride generator accessory coupled with atomic absorption spectrophotometer

Lalwani

Dogra

Bhardwaj

et al. 2004

Indian J Clin Biochem

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Surveillance of drinking water is essentially a health measure intended to protect the public from water borne diseases. Hydride generator accessory coupled with atomic absorption spectrophotometer was used to analyze arsenic level in 49 ground water samples collected from different areas of Delhi. Arsenic level in ground water samples was in the range of 0.0170 to 0.100 ppm (Mean-0.0431, Standard Deviation-0.0136, Std. error of Mean-0.00194) with minimum concentration at Raney Well No. 7 (0.0170 ppm) and maximum at Kotla Mubarak Pur (0.100 ppm). Arsenic containing sediments and percolation of chemicals into soil as the result of dumping of garbage rich in chemicals into open landfills could be the possible source of arsenic in ground water of Delhi. Extensive survey and continuous monitoring is required to be made to assess the magnitude of problem and earlier intervention. KEY WORDSArsenic, ground water, hydride generator accessory, atomic absorption spectrophotometer.

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Section: Indian Journal Of Clinical Biochemistry 2004mentioning

confidence: 77%

Study on arsenic level in ground water of Delhi using hydride generator accessory coupled with atomic absorption spectrophotometer

Lalwani

Dogra

Bhardwaj

et al. 2004

Indian J Clin Biochem

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“…Inorganic arsenic occurs naturally in the groundwater of many parts of the world, and millions of people worldwide are exposed to drinking water containing this known carcinogen (1)(2)(3)(4)(5)(6)(7)(8)(9). Ingested arsenic causes cancers of the skin, bladder, and lung and has been associated with cancers of other organs (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Intraindividual Variability in Arsenic Methylation in a U.S. Population

Steinmaus

Yuan

Kalman

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Several recent investigations have reported associations between a reduced capacity to fully methylate inorganic arsenic and increased susceptibility to arsenic-caused cancer. In these studies, methylation patterns were based on a single assessment of urinary arsenic metabolites collected at the time of cancer diagnosis. However, the latency of arsenic-caused cancer may be several decades, and the extent to which a recent measurement can be used to estimate a person's past methylation pattern is unknown. In this investigation, the distribution of urinary inorganic arsenic, monomethylarsonate, and dimethylarsinate was used to assess intraindividual variation in methylation capacity in 81 subjects with low to moderate arsenic exposures. Multiple urine samples were collected from each subject over a 1-year period. Duplicate analyses done on 27 samples were used to assess laboratory measurement imprecision. The intraclass correlation coefficients (ICC) for the proportion of urinary arsenic as inorganic arsenic, monomethylarsonate, and dimethylarsinate in samples taken an average of 258 days apart, were 0.45 [95% confidence interval (95% CI), 0.23-0.63] 0.46 (95% CI, 0.24-0.64), and 0.49 (95% CI, 0.28-0.66). In analyses of duplicate samples, ICCs for the concentration of arsenic species ranged from 0.87 to 0.93, whereas ICCs for species proportions ranged from 0.63 to 0.76. These data suggest that individual methylation patterns remain fairly stable over time, although variability due to measurement imprecision or intraindividual changes over time does occur. This variability could lead to misclassification of methylation patterns and could bias relative risk estimates in studies of methylation and cancer towards the null.

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“…LiAsia, arsenic-ladcn groundwatcr is rcported in Taiwan (Lu 1990;Chcn ct al. 1994), China (Lianfang and Jianzhong 1994;Luo et al 1997), Japan (Terade et al 1960), southern Thailand (Choprapawon and Rodcline 1997), West Bengal, India (PHED 1991Chatterjee et al 1995;Bagla andKaiser 1996: Bhattacharya et al 1997), and most recently from Bangladesh (Dhar etal.19971, Nickson et al 1998;von Brdmssen 1999). Tablc 2 summarizes the salient aspects of thc distribution, concentration, and thc possiblc mcchanism for the release of arsenic in groundwater in a fcw affected countries.…”

Section: 2 Lvatural Sourcesmentioning

confidence: 99%