Chronic application of NMDA decreases the NMDA sensitivity of the evoked tectal potential in the frog

Debski, EA; Cline, HT; McDonald, J. W.; Constantine‐Paton, Martha

doi:10.1523/jneurosci.11-09-02947.1991

Cited by 32 publications

(17 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However this exposure does alter the response of these tecta to applied NMDA (Debski et al, 1989). In normal animals acute exposure to low micromolar concentrations of NMDA virtually eliminates the postsynaptic response evoked by electrical stimulation of the optic nerve (Fig.…”

Section: Physiology Of Chronically Treated Animalsmentioning

confidence: 94%

“…In contrast to the lack of activity in TTX-treated animals (Reh and Constantine-Paton, 1985), retinal afferents in APVtreated animals still fire in response to changes in illumination . and evoked postsynaptic responses are still recorded in the tectum (Debski, Cline, and Constantine-Paton. 1989).…”

Section: Activity-dependent Fine-tuningmentioning

confidence: 99%

“…Chronic APV or NMDA treatment alters finetuning in the tectum without affecting the number of either retinal ganglion or tectal cells or blocking retinotectal transmission Debski et al, 1989). However this exposure does alter the response of these tecta to applied NMDA (Debski et al, 1989).…”

Section: Physiology Of Chronically Treated Animalsmentioning

confidence: 99%

See 2 more Smart Citations

Activity‐dependent tuning and the NMDA receptor

1990

View full text Add to dashboard Cite

The refinement of the topographic map of visual space within the optic tectum of the frog is activity-dependent. The use of the three-eyed frog preparation to assay the operation of this fine-tuning mechanism indicates that this process is mediated by the NMDA receptor: Chronic in vivo treatment with APV, an NMDA antagonist, disrupts the segregation of retinal afferents into eye-specific zones while NMDA treatment sharpens this pattern. This latter effect is accompanied by a decreased sensitivity of the system to applied NMDA. Activation of the NMDA receptor may mediate the fine-tuning mechanism by initiating the stabilization of appropriate synapses. The requirements for NMDA receptor activation necessitate the convergence of terminals carrying correlated activity patterns. Such patterns of activity are provided by ganglion cells whose cell bodies lie near one another in the retina, and who should therefore, in an accurate visual map, terminate near one another in the tectum. Synapses from ganglion cells who do not neighbor one another in the retina have uncorrelated firing patterns and therefore do not activate the NMDA receptor. These synapses then would not be stabilized relative to one another. In addition to organizing the retinal projection, NMDA receptor activation may also modulate retinal ganglion cell arbor morphology, since chronic in vivo APV or NMDA treatments decrease arbor density. These results are discussed in terms of the effect of NMDA receptor activation on branch initiation and the rate of branch retraction.

show abstract

Section: Physiology Of Chronically Treated Animalsmentioning

confidence: 94%

Section: Activity-dependent Fine-tuningmentioning

confidence: 99%

See 1 more Smart Citation

Activity‐dependent tuning and the NMDA receptor

1990

View full text Add to dashboard Cite

show abstract

“…Phosphorylation (Kutsuwada et al, 1992;Tingley et al, 1993) and interaction with the cytoskeleton (Rosenmund and Westbrook, 1993) have been shown to modulate the activity of NMDA receptors. Whatever is the exact mechanism, it may also occur in vivo since NMDA treatment of the tadpole tectum results in a decrease in sensitivity to NMDA without a change in NMDA receptor number (Debski et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Plasticity of NMDA Receptor Expression During Mouse Cerebellar Granule Cell Development

Didier

Mienville

Soubrié

et al. 1994

Eur J of Neuroscience

View full text Add to dashboard Cite

A period of hypersensitivity to N-methyl-D-aspartate (NMDA) has been described during the early development of different types of neuron. Since activation of NMDA receptors can also induce rapid neuron death, the hypersensitivity to NMDA may be tightly controlled. In the present study we show that mouse cerebellar granule neurons become transiently hypersensitive to NMDA between days 10 and 14 after plating in a culture medium containing 30 mM K+. The NMDA sensitivity is higher when cells are cultured in the presence of an NMDA receptor antagonist [30 mM K+ plus 100 microM 3-((+/-)-2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP)], and no hypersensitivity is observed when cells are cultured in the continuous presence of NMDA (12.5 mM K+ plus 100 microM NMDA). The high NMDA sensitivity in control cells is associated with a higher density of NMDA receptors than that measured in NMDA-treated cells, suggesting that the sensitivity to NMDA may be partly controlled by activity-dependent NMDA receptor down-regulation. We also examined the level of NMDA-zeta 1 mRNA and found no correlation between this parameter and the transient pattern of NMDA sensitivity. Such NMDA receptor plasticity may be of importance in the central nervous system, protecting developing cells from excitotoxicity at critical developmental stages.

show abstract

“…This mechanism has been hypothesized to explain the effects of chronic NMDA treatment on field potentials in Rana pipiens (Debski et al, 1989). If NMDA receptors are present on inhibitory interneurons, then a differential desensitization of these receptors by chronic NMDA application would decrease tectal inhibition and result in increased tectal cell firing.…”

Section: Implications Of the Datamentioning

confidence: 99%

Chronic effects of NMDA and APV on tectal output in Xenopus laevis

Scherer

Udin

1991

Vis Neurosci

View full text Add to dashboard Cite

In the South African clawed-toed frog Xenopus laevis, visual experience plays a crucial role in the formation of matching binocular maps in the tectum. The ipsilateral eye's projection, relayed through the crossed isthmotectal projection, displays marked plasticity in response to altered visual input during a critical period of development. This plasticity and the events responsible for the end of the critical period are mediated by N-methyl-D-aspartate (NMDA) receptor function. We have previously reported that chronic blockade of tectal NMDA receptors with the NMDA antagonist 5-amino-phosphonovaleric acid (APV) prevents plasticity of the crossed isthmotectal projection during the critical period, while chronic treatment with NMDA restores this plasticity after the end of the critical period. These results raise the question of whether the effects on plasticity are due to changes in electrical responsiveness of the treated tissue. In this study, we have quantitatively assessed the actions of APV and NMDA on certain aspects of tectal cell activity in Xenopus during and after the critical period by recording the output of the nucleus isthmi cells that are activated by the tectum after three weeks of treatment. We have found that chronic APV treatment does not alter tectal output, as indicated by the firing of isthmotectal axons, during the critical period and that chronic NMDA treatment increases tectal output in postcritical period Xenopus. Tectal output does not differ between normal Xenopus during and after the end of the critical period.These results indicate that the effect of APV on blocking isthmotectal plasticity is not due to a nonspecific inhibition of the segment of the retinotectal relay that activates the nucleus isthmi. The enhancement of tectal output in postcritical period Xenopus by chronic NMDA treatment may promote the effectiveness of NMDA in restoring isthmotectal plasticity after the end of the critical period, but the finding that tectal activity does not differ between normal Xenopus during and after the critical period implies that a reduction in tectal activity in not the cause of the loss of plasticity at the end of the critical period.

show abstract

Chronic application of NMDA decreases the NMDA sensitivity of the evoked tectal potential in the frog

Cited by 32 publications

References 62 publications

Activity‐dependent tuning and the NMDA receptor

Activity‐dependent tuning and the NMDA receptor

Plasticity of NMDA Receptor Expression During Mouse Cerebellar Granule Cell Development

Chronic effects of NMDA and APV on tectal output in Xenopus laevis

Contact Info

Product

Resources

About