Chronic Allograft Damage Index (CADI) as a Biomarker in Kidney Transplantation

Helanterä, Ilkka; Ortiz, Fernanda; Koskinen, Petri

doi:10.1007/978-94-007-7743-9_34-1

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…The histopathological alterations precede kidney function loss, and histopathological scoring of the damage in a functional kidney provides beneficial information to clinicians in predicting allograft prognosis. 4 …”

Section: Discussionmentioning

confidence: 99%

“…Previous studies recommend using the CADI as a part of routine clinical assessment when interpreting transplanted kidney biopsies. 4 A strong relationship has been reported between the CADI and graft survival and functions. 5 …”

mentioning

confidence: 98%

“…The studies in the literature have established a strong relationship between the CADI and graft survival and functions. 4 , 5 , 10 , 11 , 12 , 13 However, no radiological method currently exists that predicts the CADI. The present study aims to evaluate the effectiveness of the SMI technique in predicting the type and severity of rejection in renal transplant patients.…”

mentioning

confidence: 99%

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A Comparison between superb microvascular imaging technique and conventional doppler ultrasound in evaluating chronic allograft damage in renal transplant recipients

Gurbuz¹,

Keven²,

Elmali³

et al. 2023

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

mentioning

confidence: 99%

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A Comparison between superb microvascular imaging technique and conventional doppler ultrasound in evaluating chronic allograft damage in renal transplant recipients

Gurbuz¹,

Keven²,

Elmali³

et al. 2023

Diagn Interv Radiol

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“…Correlaciona con la función del injerto y el desenlace tardío del injerto y puede ser usado como un marcador subrogado en ensayos clínicos, también es útil en la toma de decisiones y da un puntaje numérico simple para la extensión del daño crónico del injerto renal. 4 La supervivencia del injerto a corto plazo ha mejorado, pasando de una probabilidad de pérdida por cualquier causa durante el primer año postrasplante renal de 9.1% en el año 2000 a 7.7% en 2011; sin embargo, este beneficio no se refleja en una mejoría significativa de la supervivencia del injerto a largo plazo. 5 Los receptores que presentan eventos de rechazo tienen 50% de riesgo incrementado de pérdida del injerto, comparado con aquéllos sin evento inmunológico durante su evolución, siendo el riesgo mayormente incrementado en los pacientes que presentan RAMA con componente vascular.…”

Section: Introductionunclassified

Biopsia protocolaria como herramienta útil para evaluar respuesta a tratamiento en rechazo agudo mediado por anticuerpos, experiencia en Centro Médico Nacional ''20 de Noviembre''

Fernández-Vivar,

Cano-Cervantes,

Matías-Carmona

et al. 2023

Revista Mexicana De Trasplantes

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Introducción: el estándar de oro para diagnosticar rechazo agudo en pacientes con trasplante renal es la biopsia de tejido. El pronóstico del injerto después del rechazo agudo tratado depende del tipo, la gravedad y prontitud con la que se identifique el evento inmunológico. El tratamiento de rechazo agudo mediado por anticuerpos (RAMA) es dirigido a remover los anticuerpos producidos por células B o por células plasmáticas, remover los anticuerpos antidonador específico (ADES) o inhibir el subsecuente daño del injerto mediado por complemento. Existen estrategias de seguimiento posterior a esquema de tratamiento antirrechazo, 1) parámetros bioquímicos; 2) respuesta histológica; y 3) medición de anticuerpos antidonador específico con títulos de intensidad media de fluoresceína.

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Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study

et al. 2017

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In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. Early introduction of paricalcitol in de novo renal transplant recipients might reduce proteinuria and prevent progressive allograft fibrosis. We performed a single-center, prospective, randomized, open-label trial investigating effects of paricalcitol 2 μg/day added to standard care. Participants were included 8 weeks after engraftment and followed for 44 weeks. Primary end point was change in spot urine albumin/creatinine ratio. Exploratory microarray analyses of kidney biopsies at study end investigated potential effects on gene expression. Secondary end points included change in glomerular filtration rate (GFR), pulse wave velocity (PWV), and endothelial function measured by peripheral arterial tonometry as reactive hyperemia index (RHI). Seventy-seven de novo transplanted kidney allograft recipients were included, 37 receiving paricalcitol. Paricalcitol treatment lowered PTH levels (P = 0.01) but did not significantly reduce albuminuria (P = 0.76), change vascular parameters (PWV; P = 0.98, RHI; P = 0.33), or influence GFR (P = 0.57). Allograft gene expression was not influenced. To summarize, in newly transplanted renal allograft recipients, paricalcitol reduced PTH and was well tolerated without negatively affecting kidney function. Paricalcitol did not significantly reduce/prevent albuminuria, improve parameters of vascular health, or influence allograft gene expression.

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Chronic Allograft Damage Index (CADI) as a Biomarker in Kidney Transplantation

Cited by 4 publications

References 41 publications

A Comparison between superb microvascular imaging technique and conventional doppler ultrasound in evaluating chronic allograft damage in renal transplant recipients

A Comparison between superb microvascular imaging technique and conventional doppler ultrasound in evaluating chronic allograft damage in renal transplant recipients

Biopsia protocolaria como herramienta útil para evaluar respuesta a tratamiento en rechazo agudo mediado por anticuerpos, experiencia en Centro Médico Nacional ''20 de Noviembre''

Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study

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