Chronic alcohol-induced liver injury correlates with memory deficits: Role for neuroinflammation

King, Jean A.; Nephew, Benjamin C.; Choudhury, Asmita; Poirier, Guillaume L.; Lim, Arlene; Mandrekar, Pranoti

doi:10.1016/j.alcohol.2019.07.005

Cited by 22 publications

(18 citation statements)

References 68 publications

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“…For example, in the object-in-place task, one (or two) of a number of familiar objects is moved, and spatial memory is operationalized as the time spent inspecting the object in the new location as opposed to the object in a familiar location. Performance in this task was impaired in female rats following 15 days of forced alcohol consumption via the Lieber-DeCarli liquid diet (increasing concentrations of alcohol up to 15%) ( King et al, 2020 ). Here, the abstinence period was only 7 h, which would put the mice in acute withdrawal, magnifying the effect on cognition.…”

Section: Methods Of Administrationmentioning

confidence: 99%

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

Charlton

Perry

2022

Front. Neurosci.

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Excessive alcohol use is often associated with accelerated cognitive decline, and extensive research using animal models of human alcohol consumption has been conducted into potential mechanisms for this relationship. Within this literature there is considerable variability in the types of models used. For example, alcohol administration style (voluntary/forced), length and schedule of exposure and abstinence period are often substantially different between studies. In this review, we evaluate recent research into alcohol-induced cognitive decline according to methodology of alcohol access, as well as cognitive behavioral task employed. Our aim was to query whether the nature and severity of deficits observed may be impacted by the schedule and type of alcohol administration. We furthermore examined whether there is any apparent relationship between the amount of alcohol consumed and the severity of the deficit, as well as the potential impact of abstinence length, and other factors such as age of administration, and sex of subject. Over the past five years, researchers have overwhelmingly used non-voluntary methods of intake, however deficits are still found where intake is voluntary. Magnitude of intake and type of task seem most closely related to the likelihood of producing a deficit, however even this did not follow a consistent pattern. We highlight the importance of using systematic and clear reporting styles to facilitate consistency across the literature in this regard. We hope that this analysis will provide important insights into how experimental protocols might influence findings, and how different patterns of consumption are more or less likely to produce an addiction-vulnerable cognitive phenotype in animal models.

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Section: Methods Of Administrationmentioning

confidence: 99%

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

Charlton

Perry

2022

Front. Neurosci.

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“…After the mice were sacrificed, the tissues at the same position in the left lobe of the liver were immediately fixed with 4% neutral formaldehyde for 24 h. After ethanol gradient dehydration, paraffin embedding and HE staining, the prepared pathological sections were histologically characterized by light microscopy [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Protective Mechanism of Polygonum perfoliatum L. Extract on Chronic Alcoholic Liver Injury Based on UHPLC-QExactive Plus Mass Spectrometry Lipidomics and MALDI-TOF/TOF Mass Spectrometry Imaging

Chen

Peng

Zhao

et al. 2022

Foods

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Polygonum perfoliatum L. has a long history of medicinal and edible applications. Studies have shown that it can significantly protect liver injury, but the mechanism is unclear. The purpose of this study was to explore the protective mechanism of P. perfoliatum on chronic alcoholic liver injury from the perspective of lipid metabolism. After 8 weeks of alcohol exposure in male Wister mice, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in serum were significantly increased, and the activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in liver were significantly decreased. Meanwhile, pathological changes of liver tissue in mice were observed by histopathology. Then, Ultra-High Performance Liquid Chromatography (UHPLC) QExactive Plus Mass Spectrometer lipidomics and matrix-assisted laser desorption/ionization time-of-flight/time -of-flight (MALDI-TOF/TOF) mass spectrometry imaging methods were established to analyze lipid metabolism in mice. Ten different lipids were identified by statistical analysis, including Fatty Acyls, Glycerophospholipids, Prenol lipids and Sphingomyelins. After intervention with P. perfoliatum extracts at different doses (25 to 100 mg/kg), levels of AST, ALT, ALP in serum, and activities of ADH and ALDH in liver were significantly corrected. The hepatic cord structure was clear, and the liver cells were closely arranged without other obvious abnormalities. Non-target lipidomics analysis showed that P. perfoliatum extract could regulate the metabolic disorders of the 10 different lipids caused by continuous alcohol exposure. Pathway analysis suggested that the mechanism of P. perfoliatum extract on chronic alcoholic liver injury may be related to the regulation of linoleic acid and α-linolenic acid.

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“…As AUD carries a social stigma, patients might tend to minimize or underestimate their use of alcohol 22 , especially if they know that this might compromise their liver transplant candidacy, although this might not apply to all patients. Another limitation is that patients with AUD and advanced ALD might present with cognitive dysfunction resulting from hepatic encephalopathy 23 . To overcome these problems, biological markers of alcohol consumption have been developed.…”

Section: Diagnosis Of Aud In Patients With Aldmentioning

confidence: 99%

Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation

Arab

Izzy

Leggio

et al. 2021

Nat Rev Gastroenterol Hepatol

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Chronic alcohol-induced liver injury correlates with memory deficits: Role for neuroinflammation

Cited by 22 publications

References 68 publications

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

Protective Mechanism of Polygonum perfoliatum L. Extract on Chronic Alcoholic Liver Injury Based on UHPLC-QExactive Plus Mass Spectrometry Lipidomics and MALDI-TOF/TOF Mass Spectrometry Imaging

Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation

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