Chronic Alcohol-Induced Alterations in the Pancreatic Secretory Control Mechanisms

Dèng, Xiǎoyīng; Wood, Paul G.; Eagon, Patricia K.; Whitcomb, David C.

doi:10.1023/b:ddas.0000030093.25897.61

Cited by 37 publications

(31 citation statements)

References 50 publications

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“…T he hypersecretor y state of the pancreas in alcoholics with LC has been ascribed to a reduced inactivation of secretin [60] or even to the increased portal pressure [24] . Recently, it has been confirmed by an experimental result that chronic alcoholism impairs the neurohormonal control of the pancreas, both at the central nervous system and acinar levels, promoting the secretory response to feeding or other stimuli [61] . All these findings regarding the inverse correlation between the alterations of liver and pancreatic function tests may be a reflection of some correlation in the etiology of both diseases.…”

Section: Discussionmentioning

confidence: 96%

Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?

Aparisi¹,

Sabater²,

Del-Olmo³

et al. 2008

WJG

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AIM:To study the possible association between chronic pancreatitis (CP) and liver cirrhosis (LC) of alcoholic etiology, after excluding any other causes. METHODS: One hundred and forty consecutive alcoholic patients were subdivided into three groups: CP (n = 53), LC (n = 57), and asymptomatic alcoholic (n = 30). Clinical, biochemical and morphological characteristics, Child-Pugh index, indocyanine green test, and fecal pancreatic elastase-1 test were assessed. RESULTS: In patients with cirrhosis, major clinical manifestations of CP such as pancreatic pain and steatorrhea, as well as imaging alterations of CP such as calcifications, duct dilation and pseudocysts were absent; insulin-dependent diabetes was present in 5.3% of cases, and elastase-1 test was altered in only 7%, and severely altered in none. In patients with CP, clinical characteristics of cirrhosis such as ascites, encephalopathy and gastrointestinal hemorrhage were present in one case, Child-Pugh grade > A in 5.7%, and altered indocyanine green test in 1.9% cases. In asymptomatic alcoholism, there was only a non-coincident alteration of elastase-1 test and indocyanine test in 14.8% and 10%, respectively, but other characteristics of cirrhosis or CP were absent. An inverse correlation (r = -0.746) between elastase-1 test and indocyanine test was found in alcoholic patients. CONCLUSION:There is a scarce coincidence in clinical and morphological alterations among patients with CP or LC of alcoholic etiology, but an inverse correlation between pancreatic and liver function tests. These findings support that these alcoholic diseases evolve in a different manner and have different etiopathogenesis.

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Section: Discussionmentioning

confidence: 96%

Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?

Aparisi¹,

Sabater²,

Del-Olmo³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…These include a signifi cant increase in the content of digestive enzymes and lysosomal enzymes within the acinar cell, accompanied by a signifi cant decrease in the stability of the organelles that contain these enzymes (zymogen granules and lysosomes, respectively). Basal pancreatic (acinar cell) secretion has recently been reported to be inhibited in ethanol-fed rats [37] . Inhibition of pancreatic secretion due to ethanol may occur at several levels including the sphincter of Oddi (spasm) [14,15] , pancreatic ducts (protein plug formation) [5] and acinar cells (disturbances in exocytosis possibly due to acetaldehyde-induced microtubular dysfunction [38] or to ethanol-induced reorganization of F-actin in the apical cytoskeleton of acinar cells as has been described in a recent in vitro study using isolated acini [39] ).…”

Section: Evidence That Ethanol Administration Induces Pancreatic Injurymentioning

confidence: 99%

Molecular Mechanisms of Alcoholic Pancreatitis

Apte

Pirola

Wilson³

2005

Dig Dis

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Alcoholic pancreatitis is a major complication of alcohol abuse. Since only a minority of alcoholics develop pancreatitis, there has been a keen interest in identifying the factors that may confer individual susceptibility to the disease. Numerous possibilities have been evaluated including diet, drinking patterns and a range of inherited factors. However, at the present time, no susceptibility factor has been unequivocally identified. In contrast, considerable progress has been made with respect to the constant effects of alcohol on the pancreas. The molecular mechanisms of alcohol-induced pancreatic injury are being increasingly defined with an emphasis, in recent years, on the acinar cell itself as the principal site on ethanol-related damage. It has now been established that the acinar cell is capable of metabolizing alcohol and that the direct toxic effects of alcohol and/or its metabolites on acinar cells may predispose the gland to autodigestive injury in the presence of an appropriate triggering factor. A significant recent development relates to the characterization of pancreatic stellate cells, increasingly implicated in alcoholic pancreatic fibrosis. Here the current concepts regarding the mechanisms/pathways mediating alcohol-induced pancreatic injury are outlined.

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“…On the other hand, a significant increase of digestive enzymes content and lysosomal enzymes within the acinar cell, followed by a significant decline in the stability of the organelles that contain these enzymes (zymogen granules and lysosomes respectively), was reported (Wilson et Pirola, 1997). Basal pancreatic (acinar cell) secretion was recently said to be inhibited in ethanol-fed rats (Deng et al, 2004). A declined acinar secretion may further increase the content of digestive enzymes in cells.…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

Effects of Daily Alcohol Intake on Serum and Salivary Alpha-Amylase Activity Associated With Two Local Alcoholic Drinks of Benin

Gomina

Sina²,

Gandekon³

et al. 2017

JBLS

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This study was initiated to assess the effect of daily amount of alcohol intake on serum and salivary alpha-amylase activity of regular adult consumers of tchoukoutou and sodabi, two local alcoholic drinks made in Benin. It was a descriptive, cross-sectional and analytical study carried out from 1 st of April to 31 st of August, 2012. The study population consisted of 50 subjects as regular consumers of tchoukoutou (titrated with 3% of alcohol), 50 regular consumers of sodabi (titrated with 40% of alcohol) and 50 non-consumers of alcohol. Alpha-amylase activity in saliva and serum were measured in each subject. There was no significant difference in the activity of serum and salivary alpha-amylase between consumers of low quantity of tchoukoutou and sodabi (˂ 30 g/ day) on one hand (P = 0.24 and 0.99 respectively), and between moderate consumers (30-79 g/ day) on the other (P = 0.31 and 0.48 respectively). Daily amount of alcohol intake had a positive effect on the serum alpha-amylase activity when taking into consideration the entire group at the threshold of 1%, in tchoukoutou consumers (r = +0.887), and in women sodabi consumers at the threshold of 5% (r = +0.928). Therefore, serum alpha-amylase activity is positively associated with the consumption of these two local alcoholic drinks made in Benin.

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Chronic Alcohol-Induced Alterations in the Pancreatic Secretory Control Mechanisms

Cited by 37 publications

References 50 publications

Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?

Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?

Molecular Mechanisms of Alcoholic Pancreatitis

Effects of Daily Alcohol Intake on Serum and Salivary Alpha-Amylase Activity Associated With Two Local Alcoholic Drinks of Benin

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