Chronic Airway Diseases in Adult Life and Childhood Infections

Ekici, Mehmet; Ekici, Aydanur; Akın, Alper; Altınkaya, Volkan; Bulcun, Emel

doi:10.1159/000102952

Cited by 18 publications

(14 citation statements)

References 35 publications

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“…First, the different types of pet animals have not been evaluated separately in the analyses. 5,16,20,21,28 Second, some studies enrolled older children. For example, Burr et al 16 found that pet ownership increased the risk of wheezing, rhinitis, and the number of cold episodes per year for 12-to 14-year-olds.…”

Section: Discussionmentioning

confidence: 99%

“…Third, studies have evaluated the associations between respiratory tract infections and animal contacts during childhood retrospectively. 21 Our study was prospective in nature, and we also analyzed results by using data collected with 2 different methods, thus making our results more reliable.…”

Section: Discussionmentioning

confidence: 99%

“…However, pet ownership has also been considered a possible risk factor for frequent childhood respiratory tract infections in some reports. 21 In the last 10 years, a large body of literature has evaluated the role of early childhood animal exposure, including household pets, in the risk of asthma or allergy in children. [22][23][24] We have previously reported a decreased tumor necrosis factor a-producing capacity at birth and in the first year of life in children exposed to indoor dogs in early life, 25 suggesting that exposure to dogs during early life may reduce innate immune responses already at birth.…”

mentioning

confidence: 99%

“…In addition, recognizing the risk factors for respiratory tract infections during childhood is important because there might be a connection between childhood respiratory tract infections and chronic airway diseases later in adulthood. 21 The aim of this study was to describe the effect of domestic animal contacts on respiratory tract infection morbidity during the first year of life. The study was based on a prospective birth cohort study with diary-based data on respiratory tract infections and animal exposures during the first year of life.…”

mentioning

confidence: 99%

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Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts

Bergroth¹,

Remes²,

Pekkanen

et al. 2012

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Respiratory infectious symptoms are common during the first year of life. Day care attendance, older siblings, and lack of breastfeeding have been considered as possible factors influencing early respiratory tract infections. WHAT THIS STUDY ADDS:Children with early dog contacts seem to have fewer infectious respiratory symptoms and diseases, especially otitis, during the first year of life. abstract OBJECTIVES: To investigate the effect of dog and cat contacts on the frequency of respiratory symptoms and infections during the first year of life. METHODS:In this birth cohort study, 397 children were followed up from pregnancy onward, and the frequency of respiratory symptoms and infections together with information about dog and cat contacts during the first year of life were reported by using weekly diaries and a questionnaire at the age of 1 year. All the children were born in eastern or middle Finland between September 2002 and May 2005. RESULTS:In multivariate analysis, children having dogs at home were healthier (ie, had fewer respiratory tract symptoms or infections) than children with no dog contacts (adjusted odds ratio, [aOR]: 1.31; 95% confidence interval [CI]: 1.13-1.52). Furthermore, children having dog contacts at home had less frequent otitis (aOR: 0.56; 95% CI: 0.38-0.81) and tended to need fewer courses of antibiotics (aOR: 0.71; 95% CI: 0.52-0.96) than children without such contacts. In univariate analysis, both the weekly amount of contact with dogs and cats and the average yearly amount of contact were associated with decreased respiratory infectious disease morbidity. CONCLUSIONS:These results suggest that dog contacts may have a protective effect on respiratory tract infections during the first year of life. Our findings support the theory that during the first year of life, animal contacts are important, possibly leading to better resistance to infectious respiratory illnesses during childhood. Pediatrics 2012;130:211-220 AUTHORS:

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts

Bergroth¹,

Remes²,

Pekkanen

et al. 2012

Pediatrics

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“…Evidence shows that environmental tobacco smoke (ETS) as well as indoor allergens such as those from dogs, cats, and cockroaches all exacerbate asthma [1,2,3,4]. In addition, increasing experimental evidence shows that ETS exposure enhances the effect of the inhaled allergen on the physiologic response in the lungs of asthmatics and experimental animals [5,6,7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Exposure to Secondhand Tobacco Smoke Enhances Respiratory Symptoms and Responses to Animals in 8,819 Children in Kindergarten: Results from 25 Districts in Northeast China

Dong¹,

Ren²,

Da³

et al. 2010

Respiration

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Background: Experimental data suggest that asthma exacerbation by allergens is enhanced by exposure to environmental tobacco smoke (ETS); however, there is little supporting epidemiologic evidence. To our knowledge, few studies have assessed respiratory symptoms and allergies in this context. Objectives: To evaluate whether the association of exposure to animals (indicators of allergen and endotoxin exposure) with asthma-related symptoms is modified by ETS exposure in Chinese children. Methods: A cross-sectional study of 8,819 children in kindergarten was conducted in 25 districts in northern China. Information on respiratory health and exposure to indoor allergens was obtained using a standard questionnaire from the American Thoracic Society. Results: Among the children with ETS exposure in utero, the effects of exposure to animals were significant with respect to persistent cough [adjusted odds ratio (OR) 1.83; 95% confidence interval (CI) 1.12–2.99] and persistent phlegm (adjusted OR 2.40; 95% CI 1.28–4.54). The combined effect of in utero ETS exposure and animal exposure on doctor-diagnosed asthma was approximately as expected on the basis of their independent effects on an additive scale. There was no interaction between animal exposure and ETS exposure in the first 2 years of life or current ETS exposure. Conclusions: This study provides evidence that animal and ETS exposure increases the risk of asthma-related symptoms in children in kindergarten. ETS exposure in utero did modify the effect of animal exposure on persistent phlegm and persistent cough but not on doctor-diagnosed asthma among children.

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Identifying patterns of immune-related disease: use in disease prevention and management

Dietert

Zelikoff

2010

World J Pediatr

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Identification of immune-related disease patterns beginning in childhood provides the framework for examining the underlying immune dysfunctions that can contribute to additional diseases in later life. Many pediatric diseases associated with dysfunctional immune responses have been linked with an elevated risk of other diseases or conditions as the child ages. Diseases within a pattern may be interlinked based on underlying immune dysfunctions and/or current therapeutic approaches for managing the entryway diseases. It may be beneficial to consider treatment options for the earliest presenting diseases that will concomitantly reduce the risk of immune-linked secondary conditions. Additionally, improved disease prevention is possible with more relevant and age-specific immune safety testing.

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Chronic Airway Diseases in Adult Life and Childhood Infections

Cited by 18 publications

References 35 publications

Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts

Respiratory Tract Illnesses During the First Year of Life: Effect of Dog and Cat Contacts

Exposure to Secondhand Tobacco Smoke Enhances Respiratory Symptoms and Responses to Animals in 8,819 Children in Kindergarten: Results from 25 Districts in Northeast China

Identifying patterns of immune-related disease: use in disease prevention and management

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