Chronic Airflow Limitation: Its Relationship to Work in Dusty Occupations

Becklake, Margaret R.

doi:10.1378/chest.88.4.608

Cited by 172 publications

(93 citation statements)

References 30 publications

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“…Work-related symptoms were common in this study population, and work-related cough was found to be more frequent among the cussent welders than among the nonwelders. Although still a matter of controversy, chronic bronchitis is known to be associated with occupations involving exposure to dusts (15), and many studies have clearly documented an excess of these symptoms for current welders (13,14,(16)(17)(18)(19)(20) and sheet metal workers exposed to welding fumes (21).…”

Section: Discussionmentioning

confidence: 99%

Respiratory symptoms, across-shift lung function changes and lifetime exposures of welders in New Zealand

Fishwick¹,

Bradshaw²,

Slater³

et al. 1997

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Respiratory symptoms, across-shift lung function changes and lifetime exposures of welders in New Zealand

Fishwick¹,

Bradshaw²,

Slater³

et al. 1997

Scand J Work Environ Health

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“…As early as 1985, however, Margaret Becklake concluded that occupational exposure to dust and/or dust and fumes may have a causal link to the pathogenesis of COPD, often relying on studies in which work-related factors were included as confounders to be adjusted for in an analysis of smoking effects (9,10). Coggon and Newman Taylor (11) made an extensive analysis of the literature on airflow obstruction among coal miners, concluding there was a significant association between exposure to coal dust and the development of chronic airflow obstruction.…”

mentioning

confidence: 99%

Occupational chronic obstructive pulmonary disease: a systematic literature review

Omland

Würtz

Aasen³

et al. 2013

Scand J Work Environ Health

117

100

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Occupational chronic obstructive pulmonary disease: a systematic literature review by Omland Ø, Würtz ET, Aasen TB, Blanc P, Brisman J, Miller MR, Pedersen OF, Schlünssen V, Sigsgaard T, Ulrik CS, Viskum S This review on occupational chronic obstructive pulmonary disease (COPD) addresses some of the potential limitations of earlier assessments by restricting the studies included to high quality epidemiological analysis involving only spirometrically confirmed air-flow obstruction as the outcome. The authors combined this with minimal requirements for exposure characterization allowing for analysis of population-based studies. Affiliation 19Review Scand J Work Environ Health. 2014;40(1):19-35. doi:10.5271/sjweh.3400 Occupational chronic obstructive pulmonary disease: a systematic literature review Objective Occupational-attributable chronic obstructive pulmonary disease (COPD) presents a substantial health challenge. Focusing on spirometric criteria for airflow obstruction, this review of occupational COPD includes both population-wide and industry-specific exposures.Methods We used PubMed and Embase to identify relevant original epidemiological peer-reviewed articles, supplemented with citations identified from references in key review articles. This yielded 4528 citations. Articles were excluded for lack of lung function measurement, insufficient occupational exposure classification, lack of either external or internal referents, non-accounting of age or smoking effect, or major analytic inadequacies preventing interpretation of findings. A structured data extraction sheet was used for the remaining 147 articles. Final inclusion was based on a positive qualitative Scottish Intercollegiate Guidelines Network (SIGN) score (≥2+) for study quality, yielding 25 population-wide and 34 industry/occupation-specific studies, 15 on inorganic and 19 on organic dust exposure, respectively. ResultsThere was a consistent and predominantly significant association between occupational exposures and COPD in 22 of 25 population-based studies, 12 of 15 studies with an inorganic/mineral dust exposure, and 17 of 19 studies on organic exposure, even though the studies varied in design, populations, and the use of measures of exposure and outcome. A nearly uniform pattern of a dose-response relationship between various exposures and COPD was found, adding to the evidence that occupational exposures from vapors, gas, dust, and fumes are risk factors for COPD. ConclusionThere is strong and consistent evidence to support a causal association between multiple categories of occupational exposure and COPD, both within and across industry groups.Key terms: airflow obstruction; COPD; dust; fume; gas; lung function measurement; occupational exposure; vapor. Chronic obstructive pulmonary disease (COPD) represents serious morbidity and has emerged as a leading cause of death worldwide (1). Although tobacco smoking is the leading factor in the etiology of COPD, the disease may be caused by inhalation of different gases and aerosols among bot...

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“…Larger-sized dust particles may be responsible for large-airways diseases such as chronic bronchitis, whereas respirable dust particles are responsible for lung parenchymal diseases such as silicosis [Morgan 1978]. In addition to physical size, the shape and density of inorganic dust particles also influence where they are deposited in the airways and whether they can be cleared from the airways [Becklake 1985]. …”

Section: Epidemiologic Studiesmentioning

confidence: 99%

Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance for Silicosis — Michigan and New Jersey, 2003–2010

Filios

Mazurek²,

Schleiff³

et al. 2015

MMWR Morb. Mortal. Wkly. Rep.

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Chronic Airflow Limitation: Its Relationship to Work in Dusty Occupations

Cited by 172 publications

References 30 publications

Respiratory symptoms, across-shift lung function changes and lifetime exposures of welders in New Zealand

Respiratory symptoms, across-shift lung function changes and lifetime exposures of welders in New Zealand

Occupational chronic obstructive pulmonary disease: a systematic literature review

Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance for Silicosis — Michigan and New Jersey, 2003–2010

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