Chronic administration of oxytocin exerts anxiolytic and antidepressant effects in a dose-independent manner in corticosterone-induced depression model of female mice
Abstract:BackgroundOxytocin (OT) is thought to have potential as a new therapeutic strategy for depression. In spite of the fact that women are at a far greater risk for depression than are men, many experimental studies use male subjects. Thus, we investigated the anxiolytic and antidepressant effects of OT on steroid-induced depression model of female mice. Methods Adult female C57BL/6J mice were injected with OT (0.01, 0.1, or 1.0 mg/kg, i.p.) and corticosterone (CORT; 40 mg/kg, s.c.) for 4 weeks. Mice were randomly… Show more
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