Chronic Administration of Methylphenidate Induced Degeneration of Spermatogenesis in Adult Male Rats

Abdollahifar, Mohammad‐Amin; Zangiabadian, Moein; Moradi, Ali; Rezaei, Fatereh; Fadai, Sina; Khatmi, Aysan; Ezi, Samira; Norozian, Mohsen; Moghoddam, Meysam Hassani; Razminia, Yasaman; Fazli, Sara; Aliaghaei, Abbas

doi:10.1007/s11094-020-02257-0

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“…Consistent with the present study, the results of Abdollahifar's study showed that consumption of Ritalin reduced sperm count and sperm motility in male mice. It also increased sedentary sperm and abnormal sperm count (Abdollahifar et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Relationship between long‐term use of Ritalin and semen parameters in patients referred to psychiatric centres

et al. 2022

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Some studies have shown that Ritalin can interfere with the growth and development of the reproductive system and can also have a serious and harmful effect on sperm parameters, so we decided to conduct studies in this field on the human sample. In a case–control study, 100 adult men aged 21–31 years with hyperactivity were divided into two groups of 50 past users and 50 current users and, 50 patients who had not used Ritalin before were included as the control group. Data were analysed using SPSS software, version 20. Analysis of variance, Pearson correlation coefficient, and regression analysis was used to assess the correlation between variables. The results also showed that there was a statistically significant difference between the current users and the control group in terms of sperm count, abnormality, and motility (p < .47). Comparison of the user group in the past and the control group showed that there was no statistically significant difference in terms of sperm count (p < .59), but there was a significant difference in terms of sperm motility and abnormality between the two groups (p < .001). The present study showed that long‐term use of Ritalin can have negative effects on sperm parameters in humans.

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Section: Discussionmentioning

confidence: 99%