Chronic administration of isocarbophos induces vascular cognitive impairment in rats

P, Li; Yin, Yulong; Zhu, Mo‐Li; Pan, Guopin; Zhao, Fei; Lu, Jianrong; Li, Zhan; Wang, Shuang‐Xi; Hu, Chong

doi:10.1111/jcmm.12775

Cited by 17 publications

(13 citation statements)

References 33 publications

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“…This condition results from the accumulation of excessive levels of acetylcholine in the synapses, glands, smooth, and skeletal muscles where cholinergic muscarinic and nicotinic receptors are found. 25 Excessive stimulation of these receptors in patients treated with rivastigmine, a dual BuChE and AChE inhibitor, comparing to patients treated with donepezil, a selective AChE inhibitor, can result in impaired cardiac and smooth muscles activity (manifested as bronchospasm, nauseas, or diarrhea), as well as fasciculations, myotonic jerks, weakness, and paresis. 25 Unfortunately, the latter symptoms can be misdiagnosed with neurological symptoms of advanced AD.…”

Section: Discussionmentioning

confidence: 99%

The Impact of a Long-Term Rivastigmine and Donepezil Treatment on All-Cause Mortality in Patients With Alzheimer’s Disease

Kaźmierski

Messini-Zachou

Γκιόκα

et al. 2018

Am J Alzheimers Dis Other Demen

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Cholinesterase inhibitors (ChEIs) are the mainstays of symptomatic treatment of Alzheimer's disease (AD); however, their efficacy is limited, and their use was associated with deaths in some groups of patients. The aim of the current study was to assess the impact of the long-term use of ChEIs on mortality in patients with AD. This observational, longitudinal study included 1171 adult patients with a diagnosis of AD treated with donepezil or rivastigmine. Each patient was observed for 24 months or until death. The cognitive and functional assessments, the use of ChEIs, memantine, antipsychotics, antidepressants, and anxiolytics were recorded. The total number of deaths at the end of the observational period was 99 (8.45%). The patients who had received rivastigmine treatment were at an increased risk of death in the follow-up period. The higher risk of death in the rivastigmine group remained significant in multivariate Cox regression models.

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Section: Discussionmentioning

confidence: 99%

The Impact of a Long-Term Rivastigmine and Donepezil Treatment on All-Cause Mortality in Patients With Alzheimer’s Disease

Kaźmierski

Messini-Zachou

Γκιόκα

et al. 2018

Am J Alzheimers Dis Other Demen

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“…The organ chamber study was performed as described previously [18,19] . Aortic rings were suspended and mounted to an organ chamber using two stainless hooks.…”

Section: Measurement Of Tension Development In Aortic Ringsmentioning

confidence: 99%

RETRACTED ARTICLE: Resveratrol rescues hyperglycemia-induced endothelial dysfunction via activation of Akt

Huang

et al. 2016

Acta Pharmacol Sin

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Resveratrol (RSV), a phytoalexin, has shown to prevent endothelial dysfunction and reduce diabetic vascular complications and the risk of cardiovascular diseases. The aim of this study was to investigate the signaling mechanisms underlying the protecting effects of RSV against endothelial dysfunction during hyperglycemia in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were treated with RSV, and then exposed to high glucose (HG, 30 mmol/L). Akt-Ser473 phosphorylation, eNOS-Ser1177 phosphorylation, and PTEN protein levels in the cells were detected using Western blot. For in vivo studies, WT and Akt mice were fed a normal diet containing RSV (400 mg·kg·d) for 2 weeks, then followed by injection of STZ to induce hyperglycemia (300 mg/dL). Endothelial function was evaluated using aortic rings by assessing ACh-induced vasorelaxation. RSV (5-20 μmol/L) dose-dependently increased Akt-Ser473 phosphorylation, accompanied by increased eNOS-Ser1177 phosphorylation in HUVECs; these effects were more prominent under HG stimulation. Transfection with Akt siRNA abolished RSV-enhanced eNOS phosphorylation and NO release. Furthermore, RSV (5-20 μmol/L) dose-dependently decreased the levels of PTEN, which was significantly increased under HG stimulation, and PTEN overexpression abolished RSV-stimulated Akt phosphorylation in HG-treated HUVECs. Moreover, RSV dramatically increased 26S proteasome activity, which induced degradation of PTEN. In in vivo studies, pretreatment with RSV significantly increased Akt and eNOS phosphorylation in aortic tissues and ACh-induced vasorelaxation, and improved diabetes-induced endothelial dysfunction in wild-type mice but not in Akt mice. RSV attenuates endothelial function during hyperglycemia via activating proteasome-dependent degradation of PTEN, which increases Akt phosphorylation, and consequentially upregulation of eNOS-derived NO production.

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“…## p < 0.01 compared to the sham group; **p < 0.01 compared to the VD group. Reported studies reveal that the drug used for the management of Alzheimer's disease attenuates the cognitive function [1,12]. Data of this study suggest that zerumbone treatment ameliorates the learning and memory of the brain function and also significantly reduces the neurological function score compared to the VD group of rats.…”

Section: Discussionmentioning

confidence: 61%

“…Vascular dementia was induced in the rats as per previously reported method [12]. All the rats were anesthetized by administration of chloral hydrate (10% w/v) intraperitoneally (i.p.)…”

Section: Methodsmentioning

confidence: 99%

Zerumbone promotes proliferation of endogenous neural stem cells in vascular dementia by regulating Notch signalling

Sun

et al. 2019

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Introduction: Present investigation determines the effect of zerumbone on the proliferation of stem cells in vascular dementia (VD) rats. Material and methods: Vascular dementia was induced by cerebral ischemia and reperfusion through non-invasive clamp. Rats were treated with zerumbone 50 mg/kg and 100 mg/kg intraperitoneally 30 min for four weeks after the surgery. Cognitive functions are determined by the Morris water maze (MWM) test and neurological function score in VD rats. Moreover mediators of inflammation and parameters of oxidative stress were estimated in the brain tissue homogenate of ischemia-induced vascular dementia rats. The expression of proteins and mRNA expressions were determined by western blot assay and RT-PCR methods. Moreover histopathological changes were observed by H&E staining on the brain tissue of vascular dementia rats. Results: There was a significant reduction in the cognitive function and neurological score in the zerumbone-treated group compared to the VD group of rats. Data of the study reveal that treatment with zerumbone attenuates the altered level of cytokines and markers of oxidative stress parameters in the brain tissue of VD rats. The expression of NICD, Hes-1 and Nestin proteins was significantly (p < 0.01) reduced in the brain tissue of the zerumbone-treated group compared to the VD group of rats. There was a significant reduction in the mRNA expression of Notch-1 and Hes-1 in the brain tissue of the zerumbone-treated group compared to the VD group of rats. Conclusions: This study concludes that treatment with zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells. Moreover proliferation of neural stem cells was stimulated in zerumbone-treated rats by regulating the Notch signalling.

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Chronic administration of isocarbophos induces vascular cognitive impairment in rats

Cited by 17 publications

References 33 publications

The Impact of a Long-Term Rivastigmine and Donepezil Treatment on All-Cause Mortality in Patients With Alzheimer’s Disease

The Impact of a Long-Term Rivastigmine and Donepezil Treatment on All-Cause Mortality in Patients With Alzheimer’s Disease

RETRACTED ARTICLE: Resveratrol rescues hyperglycemia-induced endothelial dysfunction via activation of Akt

Zerumbone promotes proliferation of endogenous neural stem cells in vascular dementia by regulating Notch signalling

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