Chronic administration of corticosterone impairs spatial reference memory before spatial working memory in rats

Coburn-Litvak, P.S.; Pothakos, K.; Tata, Despina Α.; McCloskey, Daniel P.; Anderson, Brenda J.

doi:10.1016/s1074-7427(03)00019-4

Cited by 101 publications

(69 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, inhibiting CORT synthesis with metyrapone on the day of training prevents stress-induced spatial memory deficits when dendritic retraction should be present (Wright et al, 2004). Finally, three weeks of CORT treatment causes CA3 dendritic retraction, but spatial memory remains intact on the Y-Maze (Coburn-Litvak et al, 2003). Therefore, CA3 dendritic retraction does not always parallel spatial memory deficits in males, and our findings with females contribute to this growing literature.…”

Section: Significancementioning

confidence: 51%

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

et al. 2005

View full text Add to dashboard Cite

Emerging data report sex differences in how the brain responds to chronic stress. Here, we investigated the effects of chronic restraint stress (6 h/day/21 days) on hippocampal morphology and function in ovariectomized female rats. Chronic restraint stress caused CA3 apical dendritic retraction in short-and long-shafted neurons, while it reduced basal dendritic arbors in long-shafted neurons only. Chronic restraint did not affect CA1 dendritic arborization, although it increased the proportion of CA1 spine heads compared with controls. Both stressed and control animals performed well on the Y-maze, a spatial memory task. However, chronic stress enhanced Y-maze performance compared with controls, which may reflect facilitated spatial memory or reduced habituation. Ymaze performance correlated with CA1 spine head proportion. This relationship suggests that spatial ability in females may be more tightly coupled with CA1 morphology, which may override the influence of CA3 dendritic retraction. Thus, this research provides additional evidence that CA3 morphology does not always parallel spatial memory.

show abstract

Section: Significancementioning

confidence: 51%

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Additional evidence illustrating that stress-induced weight loss is not dependent upon food access is shown in studies using the stress hormone, corticosterone. Rats administered corticosterone (via drinking water or daily injections) over weeks show decreased weight gain compared to control counterparts (Coburn-Litvak et al, 2003;Conrad et al, 2004;Sousa et al, 1998;Watanabe et al, 1992a). In another example, rats exposed to daily tone-footshock pairings showed reduced weight gain over 21 days compared to controls given tones without footshock (Trentani et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

The effects of chronic stress on hippocampal morphology and function: An evaluation of chronic restraint paradigms

et al. 2007

View full text Add to dashboard Cite

Chronic restraint stress for 6h/21d causes hippocampal CA3 apical dendritic retraction, which parallels spatial memory impairments in male rats. Recent research suggests that chronic immobilization stress for 2h/10d induces CA3 dendritic retraction (Vyas et al., 2002) and questions whether CA3 dendritic retraction and spatial memory deficits can be produced sooner than found following 6h/21d of restraint stress. Therefore, this study investigated the effects of four different durations of chronic restraint stress (varied by hours/day and total number of days) and the subsequent effects on hippocampal CA3 morphology and spatial memory in the same male Sprague-Dawley rats. The results showed that only rats exposed to the 6h/21d restraint paradigm exhibited CA3 apical dendritic retraction, consistent spatial memory deficits, and decreased body weight gain compared to experimental counterparts and controls. While chronically stressing a rat with wire mesh restraint has a physical component, it acts primarily as a psychological stressor, and these findings support the interpretation that chronic psychological stress produces hippocampal-dependent cognitive deficits that are consistent with hippocampal structural changes. Differences in stress effects observed across different studies may be due to rat strain, type of stressor, and housing conditions; however, the current findings support the use of chronic restraint stress, with wire mesh, for 6h/21d as a reliable and efficient method to produce psychological stress and to cause CA3 dendritic retraction and spatial memory deficits in male Sprague-Dawley rats.

show abstract

“…Repeated administration of corticosterone facilitates the acquisition of emotional memory, particularly by improving the consolidation and retention phases, ensuring the transition from short-to long-term memory Rose, 1994, 1997;Coburn-Litvak et al, 2003;Thompson et al, 2004). Therefore, the high corticosterone levels measured in PCAF KO mice may interfere with long-term memory, particularly as measured in the passive avoidance procedure.…”

Section: Discussionmentioning

confidence: 99%

Altered Memory Capacities and Response to Stress in p300/CBP-Associated Factor (PCAF) Histone Acetylase Knockout Mice

Maurice

Duclot

Meunier

et al. 2007

Neuropsychopharmacol

133

104

View full text Add to dashboard Cite

Chromatin remodeling by posttranslational modification of histones plays an important role in brain plasticity, including memory, response to stress and depression. The importance of H3/4 histones acetylation by CREB-binding protein (CBP) or related histone acetyltransferase, including p300, was specifically demonstrated using knockout (KO) mouse models. The physiological role of a related protein that also acts as a transcriptional coactivator with intrinsic histone acetylase activity, the p300/CBP-associated factor (PCAF), is poorly documented. We analyzed the behavioral phenotype of homozygous male and female PCAF KO mice and report a marked impact of PCAF deletion on memory processes and stress response. PCAF KO animals showed short-term memory deficits at 2 months of age, measured using spontaneous alternation, object recognition, or acquisition of a daily changing platform position in the water maze. Acquisition of a fixed platform location was delayed, but preserved, and no passive avoidance deficit was noted. No gender-related difference was observed. These deficits were associated with hippocampal alterations in pyramidal cell layer organization, basal levels of Fos immunoreactivity, and MAP kinase activation. PCAF KO mice also showed an exaggerated response to acute stress, forced swimming, and conditioned fear, associated with increased plasma corticosterone levels. Moreover, learning and memory impairments worsened at 6 and 12 months of age, when animals failed to acquire the fixed platform location in the water maze and showed passive avoidance deficits. These observations demonstrate that PCAF histone acetylase is involved lifelong in the chromatin remodeling necessary for memory formation and response to stress.

show abstract

Chronic administration of corticosterone impairs spatial reference memory before spatial working memory in rats

Cited by 101 publications

References 33 publications

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

Chronic stress enhances spatial memory in ovariectomized female rats despite CA3 dendritic retraction: Possible involvement of CA1 neurons

The effects of chronic stress on hippocampal morphology and function: An evaluation of chronic restraint paradigms

Altered Memory Capacities and Response to Stress in p300/CBP-Associated Factor (PCAF) Histone Acetylase Knockout Mice

Contact Info

Product

Resources

About