Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate

Kotake, Yaichiro; Yoshida, Masaki; Ogawa, Matsuo; Tasaki, Yoshikazu; Hirobe, Masaaki; Ohta, Shigeru

doi:10.1016/0304-3940(96)13065-2

Cited by 63 publications

(38 citation statements)

References 12 publications

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“…Many TIQ derivatives have been found in animals, including humans, as endogenous amines (Sjoquist and Ljungquist, 1985;Kohno et al, 1986;Kotake et al, 1,995;Nakagawa et al, 1996), and some of them may be related to the pathogenesis of parkinsonism or Parkinson's disease (Ohta et al, 1987;Nagatsu and Yoshida, 1988;Tasaki et al, 1991;Maruyama et al, 1993;Kotake et al, 1995Kotake et al, , 1996. We report here that 3 ',4 'DHBnTIQ and 6,7DHBnTIQ also exist in mouse brain as endogenous parkinsonism-related TIQ derivatives.…”

Section: Discussionmentioning

confidence: 51%

“…TIQ and 1-benzyl-1 ,2,3,4-tetrahydroisoquinoline (1BnTIQ) could induce parkinsonism in rodents (Tasaki et al, 1991;Kotake et al, 1995) and a primate (Kotake et al, 1996), and 1BnTIQ existed in CSF of parkinsonian patients at about three times higher levels than in disease controls (Kotake et al, 1995). Thus, TIQ and 1BnTIQ are plausible candidates as Parkinson's disease-inducing substances, but we speculated that other neurotoxins might also be present in the CNS.…”

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confidence: 99%

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Novel Endogenous 1,2,3,4‐Tetrahydroisoquinoline Derivatives: Uptake by Dopamine Transporter and Activity to Induce Parkinsonism

Kawai

Makino

Hirobe

et al. 1998

Journal of Neurochemistry

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Section: Discussionmentioning

confidence: 51%

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confidence: 99%

Novel Endogenous 1,2,3,4‐Tetrahydroisoquinoline Derivatives: Uptake by Dopamine Transporter and Activity to Induce Parkinsonism

Kawai

Makino

Hirobe

et al. 1998

Journal of Neurochemistry

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“…1-Benzyl-TIQ (25b) derivatives occur naturally in animal brain tissue, and they induce parkinsonism in monkeys and mice. 19,54) …”

Section: Synthesis Of Tetrahydroisoquinoline Derivativesmentioning

confidence: 99%

“…54) 1-Benzyl-TIQ is a neurotoxin that causes parkinsonism in humans, and it is present in the cerebro-spinal fluid of parkinsonian patients at about three times the concentration found in healthy individuals. 19) In addition, L-deprenyl, a drug used in the treatment of PD, decreased endogenous levels of 1-benzyl-TIQ in mouse brains.…”

Section: Neurotoxicity Of 1-benzyl-1234-tetra-hydroisoquinoline (1mentioning

confidence: 99%

“…19,54) Recently, Storch et al reported that 2[N]-methylated isoquinoline derivatives were selectively toxic to dopaminergic neurons via uptake by the DAT, and they may play a role in the pathogenesis of PD. 92) On the other hand, Okuda et al investigated the effects of various neuroprotective 1-methyl-TIQ derivatives on salsolinol induced cell death in vitro, and they reported hydroxymethylated 1-methyl-TIQ had more potential for treating PD.…”

Section: Neurotoxicity Of 1-benzyl-1234-tetra-hydroisoquinoline (1mentioning

confidence: 99%

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Synthesis and Neurotoxicity of Tetrahydroisoquinoline Derivatives for Studying Parkinson's Disease

Abe

Saitoh

Horiguchi

et al. 2005

Biological & Pharmaceutical Bulletin

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Parkinson's disease involves the progressive degeneration of dopaminergic neurons in the substantia nigra. However, the etiology of the disease remains to be elucidated. Endogenous amines, such as 1,2,3,4-tetrahydroisoquinoline (TIQ) derivatives present in the mammalian brain, are known to participate in the pathogenesis of Parkinson's disease. These endogenous neurotoxins have been extensively studied because of their structural resemblance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an agent widely used for generating animal models of Parkinson's disease-like symptoms. Investigations of the synthesis and pharmacological properties of TIQ derivatives are expected to contribute to the development of new therapeutic agents for treating Parkinson's disease. In the present study, we describe more efficient synthesis methods for TIQ derivatives via Pummerertype cyclization of the substrate N-acyl sulfoxide. Furthermore, the modified Pummerer reaction provided a convenient and efficient method for synthesizing various TIQs. TIQ and its derivative, 1-benzyl-TIQ, can induce parkinsonism in primates and rodents. On the other hand, one TIQ derivative, 1-methyl-TIQ, has been shown to prevent MPTP, TIQ, and 1-benzyl-TIQ induced behavioral abnormalities. Therefore, TIQ derivatives are considered to play an important role in both the onset and prevention of Parkinson's disease. In this article, we focus on the synthesis and pharmacological aspects of 1,2,3,4-tetrahydroisoquinoline derivatives in Parkinson's disease.

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Diet and Parkinson's disease: A potential role of dairy products in men

Chen¹,

Zhang

Hernán

et al. 2002

Annals of Neurology

128

113

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Diet may play a causative role in Parkinson's disease (PD), but potential associations between diet and PD risk rarely have been assessed in prospective studies. We investigated associations between food intakes and PD risk in two large prospective cohorts in which 210 incident PD cases in men and 184 in women were documented. A positive association was found between dairy intake and PD risk in men (relative risk [RR] comparing extreme categories, 1.8; p trend = 0.004), but not in women (RR, 1.1; p trend = 0.9). No other food groups were associated with PD risk in either men or women. Further analyses among men showed significant positive associations with PD risk for intakes of several dairy foods as well as dairy calcium (RR, 1.5; p trend = 0.02), dairy vitamin D (RR, 1.6; p trend = 0.004), dairy protein (RR, 1.6; p trend = 0.01), and lactose (RR, 1.8; p trend = 0.002), but not dairy fat (RR, 1.1; p trend = 0.4). Intakes of calcium, vitamin D, and protein from other dietary or supplemental sources were not related to PD risk in men. Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified.

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Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate

Cited by 63 publications

References 12 publications

Novel Endogenous 1,2,3,4‐Tetrahydroisoquinoline Derivatives: Uptake by Dopamine Transporter and Activity to Induce Parkinsonism

Novel Endogenous 1,2,3,4‐Tetrahydroisoquinoline Derivatives: Uptake by Dopamine Transporter and Activity to Induce Parkinsonism

Synthesis and Neurotoxicity of Tetrahydroisoquinoline Derivatives for Studying Parkinson's Disease

Diet and Parkinson's disease: A potential role of dairy products in men

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