Chromosomes of SV40 Transformed Human Amnion Cells After Mycoplasma Infection

Fogh, Jørgen; Fogh, H; Am, Dowling

doi:10.3181/00379727-135-35020

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1971

1985

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Cited by 7 publications

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Viruses (Nichols, 1970) and mycoplasma (Fogh, Fogh, and Dowling, 1970) can damage chromosomes. Chromosomal abnormalities have been described in scleroderma (Emerit, Housset, Grouchy, and Camus, 1971) and in NZB mice with autoimmune disease (Halpem, Emerit, Housset, and Feingold, 1972).

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mentioning

confidence: 99%

Action of chloroquine phosphate in rheumatoid arthritis. II. Chromosome damaging effect.

Neill¹,

Panayi²,

Duthie³

et al. 1973

Annals of the Rheumatic Diseases

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mentioning

confidence: 99%

Action of chloroquine phosphate in rheumatoid arthritis. II. Chromosome damaging effect.

Neill¹,

Panayi²,

Duthie³

et al. 1973

Annals of the Rheumatic Diseases

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Genetic mechanisms in cancer predisposition.Report of a cancer family

Meisner

Gilbert

Ris

et al. 1979

Cancer

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A family is described in which four children developed cancer affecting different organs: lymphoma, meningeal sarcoma, osteogenic sarcoma, and adenocarcinoma of the cecum. Since there was only one other case of cancer in previous generations of this family, an hypothesis is put forth to explain this unusual aggregation on the basis of recombination of common genes. It is postulated that each parent carried a different combination of genes which, though not associated with increased cancer predisposition in the combinations in which they were present in the parents, due to independent assortment resulted in a combination producing cancer susceptibility in half of the offspring. Such genetic loci could include factors similar to an oncogene which is normally held in control by genes at another locus; thus the dominant oncogene without the dominant controlling genes would make for cancer susceptibility, while the controlling genes without the oncogene would be associated with cancer resistance since two mutations would then be required for malignant development. To explain the occurrence of lymphoma in one of the children in this family, a third set of genes is included in this model-genes affecting immunocompetence, in which the normal allele is dominant. This three locus model has the advantage of being able to explain not only the occasional cancer family, but also the distribution of cancer susceptibility and resistance in the general population.

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