Chromosomes of Human Cancer Cells

Spriggs, A. I.; Boddington, Michael M.; Clarke, C

doi:10.1136/bmj.2.5317.1431

Cited by 134 publications

(30 citation statements)

References 10 publications

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“…The occurrence of double chromatin bodies in human tumours was first observed by Spriggs, Boddington and Clarke (1962) and reported in more detail by Lubs and Salmon (1965) and Cox et al (1965). In the latter report, 6 tumours were described including recurrence 1 of the present case, in all of which a proportion of the cells observed showed the similar phenomenon of varying numbers of very small double chromatin bodies.…”

Section: Discussionsupporting

confidence: 64%

Chromosome changes in a rhabdomyosarcoma during recurrence and in cell culture.

White¹,

Cox²

1967

Br J Cancer

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Section: Discussionsupporting

confidence: 64%

Chromosome changes in a rhabdomyosarcoma during recurrence and in cell culture.

White¹,

Cox²

1967

Br J Cancer

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“…Atkin (1960) has attempted to determine the chromosome complement of carcinomas of the cervix and has found, despite frequent polyploidy, that the sex chromosomes are sometimes lost. Spriggs, Boddington and Clarke (1962) have confirmed the frequency or variability of polyploidy and alloploidy in carcinoma of various sites. This too can invalidate theories based oIn observations other than the actual karyotypes of tumours.…”

Section: Resultsmentioning

confidence: 61%

Nuclear Sex of Testicular Teratomas

Ad¹

1963

Br J Cancer

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“…Double minute chromosomes (drain), another type of unusual abnormality (Spriggs et al, 1962), are small, paired chromatin bodies whose number and size vary from one cell to another (Barker and Hsu, 1979;Cox et al, 1965). These chromosome aberrations are not uncommon in primary cells or cell lines of human or animal tumors.…”

Section: Introductionmentioning

confidence: 99%

Determination of chromosomal area of double minute chromosomes and a homogeneously staining region in HL-60 human leukemia cells by the use of a color image analyzer

et al. 1986

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SummaryThe surface area of chromosomes was measured in two sublines of HL-60 human leukemia cells using a color image analyzer. One subline, HL-60 (drain), had double minute chromosomes (dmin) and the other line, HL-60 (HSR), showed an abnormal chromosome #8 (8q +) which contained a homogeneously staining region (HSR) within the long arm at band q24. Drain were not seen in the latter cells. The area of individual chromosomes analyzed from metaphase plates of Giemsa-stained photographic prints proved to be reasonably accurate and reproducible. Moreover, the relative area of each chromosome correlated well both with the relative length of corresponding chromosomes and the relative DNA content. The results indicate that the mean area of a single drain represents 0.16% of the total genomic area of HL-60 (dmin) cells. The average number of dmin per cell was 8.14, and the total area of all dmin in a representative cell was 1.32% of the entire genome. The 8q+ chromosome had 1.46 times the area of the normal homologous chromosome #8, and the HSR itself had 1.30% of the total chromosomal area of HL-60 (HSR) cells. Thus, perhaps coincidentally, the relative amount of DNA in the HSR in an HL-60 (HSR) cell was similar to the total found in multiple dmin in HL-60 (drain) cells.

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Chromosomes of Human Cancer Cells

Cited by 134 publications

References 10 publications

Chromosome changes in a rhabdomyosarcoma during recurrence and in cell culture.

Chromosome changes in a rhabdomyosarcoma during recurrence and in cell culture.

Nuclear Sex of Testicular Teratomas

Determination of chromosomal area of double minute chromosomes and a homogeneously staining region in HL-60 human leukemia cells by the use of a color image analyzer

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