Chromosomes and causation of human cancer and leukemia.VIII. DMS chromosomes in a neuroblastoma

Sandberg, Avery A.; Sakurai, Masaharu; Holdsworth, Robert N.

doi:10.1002/1097-0142(197206)29:6<1671::aid-cncr2820290635>3.0.co;2-c

Cited by 53 publications

(19 citation statements)

References 15 publications

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“…Double minutes were found in 1% of the metaphases of our neuroblastomas. On the other hand the dms were reported in 7/39 published cases (Cox et al, 1965;Cox, 1968;Leven et al, 1968;Sandberg et al, 1972;Schlesinger et al, 1976). They were present in 70% of the cells but they varied in size and in number from one to > 100 dms per cell.…”

Section: Discussionmentioning

confidence: 96%

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Chromosomal analysis of neuroblastoma

Hafez¹,

el-Meadday²,

Sheir³

et al. 1985

Br J Cancer

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Summary Ten children with abdominal neuroblastoma were included in the study. Biopsies from the neuroblastomas were taken during surgical operations, nine from the primary tumours and one from a metastasis. Histopathology was done for diagnosis. Chromosomal cultures of neuroblastoma cells and peripheral blood lymphocytes were performed.The peripheral blood lymphocytes revealed normal chromosomal complements. The 10 tumours were in the peridiploid range with random gains or losses of chromosomes. Deletion of the short arm of chromosome number 1 distal to band p31 occurred in 6 tumours. Other structural changes and giant markers were found. It was concluded that a regulatory gene controlling the transformation gene of neuroblastoma, is present at or distal to lp31.

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Section: Discussionmentioning

confidence: 96%

“…The reported chromosome numbers in neuroblastomas vary considerably but are in the peridiploid range (Brewster & Garrett, 1965;Brodeur et al, 1977). Sandberg et al (1972) reported double minute chromosomes in neuroblastoma, while Brodeur et al (1977) could not confirm this. However, these were also found frequently in glial as well as other neurogenic tumours.…”

mentioning

confidence: 97%

Chromosomal analysis of neuroblastoma

Hafez¹,

el-Meadday²,

Sheir³

et al. 1985

Br J Cancer

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“…At the same time another English team (LUEIS and SALMON 1965) studying a human medulloblastoma arrived at the same conclusion on the basis of actual observations of "definite ring chromosomes" in the tumor cells. Also SANDBERG et al (1972) expressed the opinion that "in all probability, the DMS represent ring chromosomes, most commonly of the acentric form" (p. 1675). QUINN et al (1979) found "variable sizes of small ring chromosomes" in addition to DM in a cell line from a human colon carcinoma (p. 4916), and ATKIN and BAKER (1980) depict clear ring DM in a human cervix carcinoma.…”

Section: A Earlier Cases Of Ring-shaped Dmmentioning

confidence: 99%

Ring-shaped double minutes in human acute myelocytic leukemia and in the murine SEW A sarcoma. A comparison

Marinello

Levan

2008

Hereditas

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ISSN 0018-0661. Received May 11, 1981 Direct bone marrow preparations for chromosome analysis in 376 patients with leukemia and/or myeloproliferative disease revealed 40 cases in which the stemlines contained varying frequencies of double minutes (DM). In the case presented, part of the DM were clearly ring-shaped and bore an amazing resemblance to those recently described in a subline of the SEWA mouse ascites sarcoma. A comparative study of incidence and morphology of the DM of the 2 materials was therefore undertaken. While they shared many characteristics, the main difference between them was the striking functional stability of the human DM versus the highly erratic behavior of the murine DM. It was striking that about half of the 12-13 cases of DM in leukemia from the literature resembled the present case in having fairly large, ring-shaped DM that, although most likely acentric, maintained a remarkable mitotic stability. The genes they carry, which speculatively may be assumed to stimulate the malignant capacity of the leukemic cells, are therefore incorporated in the stemline karyotype much more permanently than ifthey had been carried by "ordinary" DM. In a recent preliminary communication, one of us has reported the finding of double minutes (DM) in the neoplastic stemlines of 40 among 376 patients presenting with preleukemia, acute leukemia and/or myeloproliferative disease ( MARINELLO et al. 1980). In 35 cases, the DM had the ordinary appearance of small or medium-sized double structures with a diameter not exceeding the chromatid breadth of the chromosomes. Their number usually varied from 0 to 5-6 per cell. In one case the DM were numerous, very small, almost "dust-like" particles, while in 4 cases they were large, their diameter being equal to or larger than the ordinary chromatid breadth. The shape of the large DM was usually ring-like.Ring-like DM of varying sizes were recently described in a transplantable murine ascites sarcoma, called SEWA. During a limited period of 1979, one specific subline of this tumor, SEWAIR, occasionally contained large DM and some of the largest were obvious rings (LEVAN and LEVAN 1980).Since large, ring-shaped DM have rarely been available for study, we decided to describe, in some detail, the DM of one of the human leukemia cases and to compare them with the DM of the SEWA sarcoma. In the present paper, we wish to report the case of a patient with acute myelocytic leukemia (AML) whose karyotype showed a low but rather consistent number of large and medium-sized ring DM in every malignant metaphase examined, to briefly review the SEWA findings, and to discuss the two.

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“…Partner chromosomes involved in these translocations include 5, 7, 12, 18, 21 and 22, whilst chromosome 20 is only rarely reported. 3 In a recent study of 25 cases of MDS/AML with therapyrelated 17p deletion, four patients had received prior melphalan. 4 The emergence of a t(17:20) clone in our patients coincided with clinical resistance to melphalan.…”

Section: The Editormentioning

confidence: 99%