Chromosome Studies During Early and Terminal Chronic Myeloid Leukaemia

Somatic rearrangement of chromosome 14 in human lymphocytes.

“…Certain parallels exist between the chromosome 14 Whether the Philadelphia translocation is reciprocal is not yet established. In any event, preliminary evidence indicates that it may predate the clinical onset of disease (27). A clone of bone marrow cells is marked in an irrevocable manner and once found, the Philadelphia chromosome presumably never entirely vanishes from the marrow of a patient with chronic myeloid leukemia (28).…”

Cytogenetic Studies in Unusual Forms of Chronic Myeloid Leukaemia

“…Case 9 in the pre sent series is interesting in this respect as his marrow, at the time of study, contained many megakaryocytes, and in the,analysable poly ploid cells 2 Ph1 chromosomes were present. It is clear that the Ph1 is not present in the lymphocytic series, as lymphocyte-derived mi toses in cultures of Phytohaemagglutinin-stimulated blood leuco cytes are clearly normal in patients with chronic myeloid leukaemia (6,14,24). These findings tend to indicate separate origins for lymphoid cells and for other blood cells, and is a strong argument against the hypothesis that lymphocytes can act as stem-cells for other cell types.…”

“…Cases exist however, in which the enzyme level may be normal or even elevated, and in a scries previously reported from this depart ment two Ph1 positive patients showed elevated alkaline phosphatase levels (5). K emp et al (14) reported 2 patients with normal levels; both had received surgical attention a few days previously, which is known to cause an elevation in alkaline phosphatase levels. Speed and Lawler (19) reported a patient whose leucocyte alkaline phosphatase level rose from leukaemic levels after the production of marrow failure following therapy.…”

Zytologische Untersuchungen zur Diagnostik und Aetiologie der Erythroleukämie

“…Bestehen in einer erheblichen Anzahl akuter Leukämien Chromosomenaberrationen, die die pathologische Entwicklung dieser Zellen unterstreicht. Bei chronisch myeloischen Leukämien tritt fast regelmässig das Philadelphia-Chromosom [12] auf, das deshalb als pathognomonisch für diese Erkrankung angesehen werden kann, wenn gleich auch Ausnahmen beschrieben sind [13,14]. 3.…”