Chromosome mapping of MHC class I in rainbow trout (Oncorhynchus mykiss)

Fujiwara, Atushi; Kiryu, Ikunari; Dijkstra, Johannes M.; Yoshiura, Yasutoshi; Nishida‐Umehara, Chizuko; Ototake, Mitsuru

doi:10.1006/fsim.2002.0426

Cited by 12 publications

(6 citation statements)

References 26 publications

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“…It has been reported that RT-3 was consistent with a sequence of MHC class Ib genes (see below; Phillips et al, 2003;Shiina et al, 2005). RT-16 was reported to be consistent with the single salmonid MHC class Ia locus (Onmy-UBA; Fujiwara et al, 2003;Phillips et al, 2003;Shiina et al, 2005), and that RT-29 accords with closely linked MHC class IIa and IIb loci (Onmy-DAA and Onmy-DAB; Phillips et al, 2003). Whereas MHC class Ib was associated with the major QTL, IPN R/S-1 on RT-3 (Fig.…”

Section: Discussionsupporting

confidence: 53%

Identification of Additional Quantitative Trait Loci (QTL) Responsible for Susceptibility to Infectious Pancreatic Necrosis Virus in Rainbow Trout

et al. 2007

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ABSTRACT-Previous typing of microsatellite markers in a BC 1 F 1 backcross rainbow trout Oncorhynchus mykiss revealed two quantitative trait loci (QTL) with a significant impact on susceptibility to infectious pancreatic necrosis. In the present study, additional genetic markers were mapped using the same strain in order to increase QTL resolution. A total of 199 individuals were screened at 226 marker loci (106 microsatellites, 116 amplified fragment length polymorphism markers, classical major histocompatibility complex molecules [MHC class I, nonclassical MHC class I, MHC class II] and tyrosinase) and the QTL were determined by single-point and interval mappings. Seven QTL were distinguished in the linkage groups 12, 17, 23, 26, 29 and 31, in addition to the two already known in RT-3 and 22. The major QTL were those in RT-3, 12 and 22; whereas the classical MHC class I locus Onmy-UBA and the MHC class II locus Onmy-DAB were not associated with any of the QTL, a nonclassical MHC class I region with Onmy-UCA, Onmy-UDA, and Onmy-UEA mapped to the major QTL on RT-3.

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Section: Discussionsupporting

confidence: 53%

Identification of Additional Quantitative Trait Loci (QTL) Responsible for Susceptibility to Infectious Pancreatic Necrosis Virus in Rainbow Trout

et al. 2007

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“…In both species, the IB region is located on chromosome 14 [6,8] (data not shown for salmon), while the IA region is located on chromosome 18 in rainbow trout and on one of the smaller chromosomes, potentially chromosome 27, in Atlantic salmon (Fig. 6) [8,44]. In Atlantic salmon, the IA and IB regions map to linkage groups 15 and 3 respectively [45], while in rainbow trout they map to linkage groups 16 and 3 [20] supporting the differences.…”

Section: Resultsmentioning

confidence: 99%

Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon (Salmo salar)

et al. 2007

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“…Rainbow trout and Atlantic salmon are the only fish species for which disease resistance related genome-wide QTL studies can readily be linked with whole genome sequence information [190,195] available at the chromosome and linkage group levels (e.g., [196,197]), and for which the locations of the classical MHC class I and II loci are known; for rainbow trout, the Onmy-IA , Onmy-IB and classical MHC class II loci (see Figure 3) were also physically mapped to chromosomes 18, 14 and 17, respectively [50,198,199]. In Atlantic salmon, the corresponding Sasa-IA , Sasa-IB and classical MHC class II loci were mapped to chromosomes 27, 14 and 12 in that species [194].…”

Section: Association Of Teleost Fish Mhc Genes With Disease Resistmentioning

confidence: 99%

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

Yamaguchi

Dijkstra

2019

Cells

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Fascinating about classical major histocompatibility complex (MHC) molecules is their polymorphism. The present study is a review and discussion of the fish MHC situation. The basic pattern of MHC variation in fish is similar to mammals, with MHC class I versus class II, and polymorphic classical versus nonpolymorphic nonclassical. However, in many or all teleost fishes, important differences with mammalian or human MHC were observed: (1) The allelic/haplotype diversification levels of classical MHC class I tend to be much higher than in mammals and involve structural positions within but also outside the peptide binding groove; (2) Teleost fish classical MHC class I and class II loci are not linked. The present article summarizes previous studies that performed quantitative trait loci (QTL) analysis for mapping differences in teleost fish disease resistance, and discusses them from MHC point of view. Overall, those QTL studies suggest the possible importance of genomic regions including classical MHC class II and nonclassical MHC class I genes, whereas similar observations were not made for the genomic regions with the highly diversified classical MHC class I alleles. It must be concluded that despite decades of knowing MHC polymorphism in jawed vertebrate species including fish, firm conclusions (as opposed to appealing hypotheses) on the reasons for MHC polymorphism cannot be made, and that the types of polymorphism observed in fish may not be explained by disease-resistance models alone.

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Chromosome mapping of MHC class I in rainbow trout (Oncorhynchus mykiss)

Cited by 12 publications

References 26 publications

Identification of Additional Quantitative Trait Loci (QTL) Responsible for Susceptibility to Infectious Pancreatic Necrosis Virus in Rainbow Trout

Identification of Additional Quantitative Trait Loci (QTL) Responsible for Susceptibility to Infectious Pancreatic Necrosis Virus in Rainbow Trout

Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon (Salmo salar)

Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish

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