Chromosome fragile sites

Yoder, Freda; Vincent, R.A.; Morgan, Samuel K.; Grush, Owen C.

doi:10.1016/0165-4608(85)90202-x

Cited by 2 publications

(1 citation statement)

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“…In addition, cells are often exposed to certain stimulatory conditions that impede DNA replication, cause replication fork suspension, and increase fork instability. The resulting DNA replication stress prevents cells from completing DNA synthesis in a timely manner during interphase, leading to chromosomal breakage and genomic instability in mitosis 12 , 13 . Regulating the operation of replication forks during replication errors is also an essential part of maintaining genome stability.…”

Section: Genome Stabilitymentioning

confidence: 99%

Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions

Zhang¹,

Guo²,

Wang³

et al. 2022

Int. J. Biol. Sci.

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It is emerging that autophagy-related proteins regulate the adaptive response to DNA damage in maintaining genome stability at multiple pathways. Here, we discuss recent insights into how autophagy-related proteins participate in DNA damage repair processes, influence chromosomal instability, and regulate the cell cycle through autophagy-dependent and independent actions. There is increasing awareness of the importance of these pathways mediated by autophagy-related proteins to DNA damage response (DDR), and disturbances in these regulatory connections may be linked to genomic instability participated in various human diseases, such as cancer and aging.

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Section: Genome Stabilitymentioning

confidence: 99%