2020
DOI: 10.3389/fmicb.2020.00926
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Chromosome Architecture and Gene Content of the Emergent Pathogen Acinetobacter haemolyticus

Abstract: Acinetobacter haemolyticus is a Gammaproteobacterium that has been involved in serious diseases frequently linked to the nosocomial environment. Most of the strains causing such infections are sensitive to a wide variety of antibiotics, but recent reports indicate that this pathogen is acquiring very efficiently carbapenem-resistance determinants like the blaNDM-1 gene, all over the world. With this work we contribute with a collection set of 31 newly sequenced nosocomial A. haemolyticus isolates. Genome analy… Show more

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Cited by 5 publications
(5 citation statements)
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“…We describe a group of 119 plasmids spanning A. baumannii strains from thirteen sequence types, and non- A. baumannii strains including A. seifertii , A. haemolyticus, and Klebsiella pneumoniae . A. seifertii and A. haemolyticus are also considered to be emerging pathogens of clinical importance [ 61 , 62 ], and carbapenem-resistant and/or MDR strains have been identified both clinically and environmentally [ 15 , 61 , 63–66 ]. A. seifertii is associated with serious human infections including bloodstream infections [ 64 , 65 ].…”
Section: Discussionmentioning
confidence: 99%
“…We describe a group of 119 plasmids spanning A. baumannii strains from thirteen sequence types, and non- A. baumannii strains including A. seifertii , A. haemolyticus, and Klebsiella pneumoniae . A. seifertii and A. haemolyticus are also considered to be emerging pathogens of clinical importance [ 61 , 62 ], and carbapenem-resistant and/or MDR strains have been identified both clinically and environmentally [ 15 , 61 , 63–66 ]. A. seifertii is associated with serious human infections including bloodstream infections [ 64 , 65 ].…”
Section: Discussionmentioning
confidence: 99%
“…The genomic DNA of A. haemolyticus AN54 was used as a PCR template to amplify different regions of one of its plasmids, pAhaeAN54e. The description and genome sequence of this strain have been published previously [15,16]. To test the replication capabilities of the constructs, a spontaneously pAhaeAN54e-cured strain resistant to rifampicin was used as a recipient for all the constructs.…”
Section: Bacterial Strains and Plasmidsmentioning
confidence: 99%
“…The pAhaeAN54e plasmid (NZ_CP041229.1), a member of the pNDM-YR7 clade, is a medium-size replicon that was identified in the Acinetobacter haemolyticus strain AN54, isolated in a Mexican hospital. This plasmid contains an NDM-1 gene linked to carbapenem resistance and an aphA6 gene involved in aminoglycoside resistance, and both genes lie close to an ISAba125 element [15,16]. This plasmid also encodes proteins involved in maintenance and transfer and 19 proteins with unknown functions.…”
Section: Introductionmentioning
confidence: 99%
“…Some outstanding species, such as A. hemolyticus, were found in the general environment and tended to cause severe clinical cases concerned with the environment in hospitals. On the other hand, AMR, particularly carbapenems, was not determined clearly [18]. A. junii has been reported in calculi obstructions in the ureter [19].…”
Section: Introductionmentioning
confidence: 99%