Chromosome anomalies as a cause of spontaneous abortion

Carr, David

doi:10.1016/0002-9378(67)90488-7

Cited by 174 publications

(59 citation statements)

References 38 publications

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“…WARKANY and TAKACS [35] could not confirm the positive findings in rats. The chromosomes of these malformed fetuses were not examined, but the study of spontaneous abortions in man [8] and mouse [28] indicate that a high proportion of such abortuses carry chromosomal aberrations. Therefore, the possibility exists of chromosomal damage in utero leading to increased numbers of abnormal The effect of LSD-25 on the chromosomes of children exposed in utero 491 offspring.…”

Section: Discussionmentioning

confidence: 99%

The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

et al. 1968

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ExtractThis paper reports the cytogenetic investigation of nine children exposed to LSD-25 ,in utero, four children of'other LSD users not exposed in utero, the mothers of these children, and six additional adults taking the drug. In comparison with matched controls, significantly elevated frequencies of chromosomal damage were observed in all the individuals exposed. The frequencies of aberrations, however, were markedly reduced in those children not exposed in utero. Eight structural rearrangements were observed, six dicentric chromosomes and two quadriradial formations, among those individuals exposed to the drug, but none was observed in the controls. In spite of obvious chromosomal aberrations, all of the individuals in this study were apparently healthy and showed no obvious birth defects. Speculation

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Section: Discussionmentioning

confidence: 99%

The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

et al. 1968

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“…There has been a considerable variation between the prevalence of abnormal karyotypes reported by different studies: the major factor influencing the proportion of abnormalities being the gestational age of the abortuses. Of the larger studies, those that included abortuses expelled up until the end of the second trimester revealed 20 to 300% abnormal karyotypes (Carr, 1967;Dhadial et al, 1970;Creasy et al, 1976) while those studies restricted to the earlier stages of pregnancy revealed 50 to 60 % of abnormalities (Therkelsen et al, 1973;Arakaki and Waxman, 1970;Kajii et al, 1973;Boue et al, 1975). From these reports it appears that the prevalence of chromosomal abnormalities in abortuses decreases from over 600% in the earliest detectable stages of pregnancy to below 5 % by the end of the sixth month.…”

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confidence: 99%

Frequency of chromosomal abnormalities in miscarriages and perinatal deaths.

Alberman¹,

Creasy²

1977

Journal of Medical Genetics

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“…While there are undoubtedly multiple causes of spontaneous abortion and congenital birth defects, high incidences of chromosomal abnormalities in human abortuses (Carr, 1965;Geneva Conference, 1966;Makino & co\ x=r eq-\ authors, 1967; Ikeuchi, Sasaki, Kohno, Hayata & Fujimoto, 1972), and in early embryos of the pig (McFeely, 1967) suggest that chromosomal imbalance may be one of the primary causes of early embryonic death.…”

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confidence: 99%